Ras Participates in CpG Oligodeoxynucleotide Signaling through Association with Toll-like Receptor 9 and Promotion of Interleukin-1 Receptor-associated Kinase/Tumor Necrosis Factor Receptor-associated Factor 6 Complex Formation in Macrophages

CpG oligodeoxynucleotides (ODN) activate immune cells to produce immune mediators by Toll-like receptor 9 (TLR9)-mediated signal transduction, which activates mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) through the MyD88/IRAK/TRAF6 kinases cascade. However, the precise me...

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Veröffentlicht in:	The Journal of biological chemistry 2003-09, Vol.278 (38), p.36334-36340
Hauptverfasser:	Xu, Hongmei, An, Huazhang, Yu, Yizhi, Zhang, Minghui, Qi, Runzi, Cao, Xuetao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Antigens, Differentiation - metabolism Blotting, Western Cell Line CpG Islands DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Enzyme Activation Genes, Dominant Genes, Reporter Interleukin-1 Receptor-Associated Kinases JNK Mitogen-Activated Protein Kinases Macrophages - metabolism Mice Mitogen-Activated Protein Kinases - metabolism Myeloid Differentiation Factor 88 NF-kappa B - metabolism Nitric Oxide - metabolism Oligonucleotides - metabolism Plasmids - metabolism Precipitin Tests Protein Binding Protein Kinases - metabolism Proteins - metabolism ras Proteins - metabolism Receptors, Cell Surface - metabolism Receptors, Immunologic - metabolism Signal Transduction Time Factors TNF Receptor-Associated Factor 6 Toll-Like Receptor 9 Transfection Tumor Necrosis Factor-alpha - metabolism
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