Cell Proliferation Arrest within Intrathymic Lymphocyte Progenitor Cells Causes Thymic Atrophy Mediated by the Aryl Hydrocarbon Receptor

Activation of the aryl hydrocarbon receptor (AHR), a basic helix-loop-helix transcription factor, in lymphocytes by the immunosuppressive environmental contaminant 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) has been shown to cause thymic atrophy in every species studied. We set out to identify the...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-11, Vol.171 (9), p.4582-4591
Hauptverfasser:	Laiosa, Michael D, Wyman, Amber, Murante, Francis G, Fiore, Nancy C, Staples, J. Erin, Gasiewicz, Thomas A, Silverstone, Allen E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy - chemically induced Cell Aggregation - drug effects Cell Aggregation - immunology Cell Death - drug effects Cell Death - immunology Cell Division - drug effects Cell Division - immunology G1 Phase - drug effects G1 Phase - immunology Growth Inhibitors - toxicity Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Kinetics Lymphocyte Subsets - drug effects Lymphocyte Subsets - metabolism Lymphocyte Subsets - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Polychlorinated Dibenzodioxins - toxicity Receptors, Aryl Hydrocarbon - biosynthesis Receptors, Aryl Hydrocarbon - deficiency Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - physiology T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology Thymus Gland - drug effects Thymus Gland - metabolism Thymus Gland - pathology
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