Second hand smoke stimulates tumor angiogenesis and growth

Exposure to second hand smoke (SHS) is believed to cause lung cancer. Pathological angiogenesis is a requisite for tumor growth. Lewis lung cancer cells were injected subcutaneously into mice, which were then exposed to sidestream smoke (SHS) or clean room air and administered vehicle, cerivastatin,...

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Veröffentlicht in:	Cancer cell 2003-09, Vol.4 (3), p.191-196
Hauptverfasser:	Zhu, Bo-qing, Heeschen, Christopher, Sievers, Richard E., Karliner, Joel S., Parmley, William W., Glantz, Stanton A., Cooke, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Lewis Lung - blood supply Carcinoma, Lewis Lung - etiology Chemokine CCL2 - metabolism Endothelial Cells - metabolism Hydroxymethylglutaryl CoA Reductases - metabolism Mecamylamine - metabolism Mice Neovascularization, Pathologic - etiology Nicotine - toxicity Pyridines - metabolism Receptors, Nicotinic - metabolism Tobacco Smoke Pollution - adverse effects Vascular Endothelial Growth Factor A - metabolism
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