Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy

Abstract Objectives: To investigate whether cerebrospinal fluid (CSF) biomarkers of neurodegeneration are altered in narcolepsy in order to evaluate whether the hypocretin deficiency and abnormal sleep–wake pattern in narcolepsy leads to neurodegeneration. Methods: Twenty-one patients with central h...

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Veröffentlicht in:	Sleep (New York, N.Y.) N.Y.), 2017-01, Vol.40 (1)
Hauptverfasser:	Jørgen Jennum, Poul, Østergaard Pedersen, Lars, Czarna Bahl, Justyna Maria, Modvig, Signe, Fog, Karina, Holm, Anja, Rahbek Kornum, Birgitte, Gammeltoft, Steen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alpha-Synuclein - cerebrospinal fluid Amyloid beta-Peptides - cerebrospinal fluid Biomarkers Biomarkers - cerebrospinal fluid Case-Control Studies Chitinase-3-Like Protein 1 - cerebrospinal fluid Female Humans Hypersomnolence, Idiopathic - cerebrospinal fluid Male Narcolepsy - cerebrospinal fluid Neurodegeneration Neurodegenerative Diseases - cerebrospinal fluid Neurofilament Proteins - cerebrospinal fluid Orexins - cerebrospinal fluid Proteins Sleep disorders tau Proteins - cerebrospinal fluid
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