Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β2 in Rat Bone Tissue after Bone Fracture and Placement of Titanium Implants with Bioactive Bioresorbable Coatings
The study established enhanced expression of vascular endothelial growth factor (VEGF) in the subpopulation of osteoblasts located in the regeneration region of femoral bone fracture near the titanium implants with bioactive calcium phosphate and hydroxyapatite coatings and suppressed activity of tr...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2017-03, Vol.162 (5), p.671-675 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Kalinichenko, S. G. Matveeva, N. Yu Kostiv, R. E. Puz’, A. V. |
| description | The study established enhanced expression of vascular endothelial growth factor (VEGF) in the subpopulation of osteoblasts located in the regeneration region of femoral bone fracture near the titanium implants with bioactive calcium phosphate and hydroxyapatite coatings and suppressed activity of transforming growth factor-β2 (TGF-β2) in chondroblasts during the two weeks after surgery. In the delayed posttraumatic period, the distribution of TGF-β2 inversely related to its maximal activity. The data revealed the up-regulating effect of bioresorbable coatings on expression of VEGF and TGF-β2 and their implication in the control over various stages of reparative osteogenesis. |
| doi_str_mv | 10.1007/s10517-017-3684-3 |
| format | Article |
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The data revealed the up-regulating effect of bioresorbable coatings on expression of VEGF and TGF-β2 and their implication in the control over various stages of reparative osteogenesis.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - pathology</subject><subject>Bone and Bones - physiopathology</subject><subject>Bone Regeneration</subject><subject>Bone Screws</subject><subject>Calcium Phosphates - chemistry</subject><subject>Cell Biology</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Durapatite - chemistry</subject><subject>Fracture Healing</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Pathology</subject><subject>Rats</subject><subject>Titanium</subject><subject>Transforming Growth Factor beta2 - physiology</subject><subject>Vascular Endothelial Growth Factor A - physiology</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUhi0EokPhAdggL9kEfMnFs6SjTqlUCVQNbK0T57h1ldiD7VDxWux5BZ4JhxQkNiwsX85_Pv_2T8hLzt5wxrq3ibOGdxUrQ7aqruQjsuFNJyslBH9MNqyIqlopdUKepXS3bFnLn5IToWTLa95syI_rMCINln6GZOYRIj33Q8i3ODoY6UUM9_mW7sHkECn4gR4i-GRDnJy_-bdc_fwuqPP0GjI9Cx7pwaU0IwWbMa4n-1iUc8TfpI8jGJzQ5-X2g8vg3TzRy-k4gs-J3rtCPnOhdLivuKwiphB76IvfXYBcDKTn5ImFMeGLh_mUfNqfH3bvq6sPF5e7d1eVEc1WVtAPijWttdIKaAFYh50ZwChp2bZGKcTWcAVb0w2m7hQ3YI3oJFNM9uU7pTwlr1fuMYYvM6asJ5cMjsUqhjlprpTkSjBVFylfpSaGlCJafYxugvhNc6aX1PSami6p6SU1veBfPeDnfsLhb8efmIpArIJUSv4Go74Lc_Tlyf-h_gLA3qYn</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Kalinichenko, S. 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| ispartof | Bulletin of experimental biology and medicine, 2017-03, Vol.162 (5), p.671-675 |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Bone and Bones - metabolism Bone and Bones - pathology Bone and Bones - physiopathology Bone Regeneration Bone Screws Calcium Phosphates - chemistry Cell Biology Coated Materials, Biocompatible - chemistry Durapatite - chemistry Fracture Healing Internal Medicine Laboratory Medicine Male Pathology Rats Titanium Transforming Growth Factor beta2 - physiology Vascular Endothelial Growth Factor A - physiology |
| title | Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β2 in Rat Bone Tissue after Bone Fracture and Placement of Titanium Implants with Bioactive Bioresorbable Coatings |
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