Parthenolide reduces gene transcription of prosurvival mediators in U937 cells

In acute myeloid leukemia (AML) the functional abnormalities of osteopontin (OPN), NF-kB, PI3K/AKT/mTOR/PTEN pathway or β-catenin have been considered. To analyze the response of U937 cells to parthenolide (PTL) through the involvement of expression of OPN protein, RelB, AKT1, mTOR, PTEN and β-caten...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental oncology 2017-03, Vol.39 (1), p.30-35
Hauptverfasser:	Mohammadi, S, Zahedpanah, M, Nikbakht, M, Shaiegan, M, Hamidollah, Ghaffari, Nikugoftar, M, Rahmani, B, Hamedi Asl, D
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Catenin - genetics beta Catenin - metabolism Blotting, Western Cell Survival - drug effects Cell Survival - genetics Dose-Response Relationship, Drug Gene Expression Regulation, Neoplastic - drug effects Humans Osteopontin - genetics Osteopontin - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Sesquiterpenes - pharmacology TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Transcription Factor RelB - genetics Transcription Factor RelB - metabolism Transcription, Genetic - drug effects Tumor Stem Cell Assay - methods U937 Cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!