Delivery of doxorubicin-loaded PLGA nanoparticles into U87 human glioblastoma cells

[Display omitted] The paramount problem in the therapy of brain tumors is the inability of most drugs to cross the blood–brain barrier. PLGA nanoparticles overcoated with poloxamer 188 could overcome this problem and enabled a high anti-tumoral effect against the very aggressive intracranial 101.8 g...

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Veröffentlicht in:	International journal of pharmaceutics 2017-05, Vol.524 (1-2), p.77-90
Hauptverfasser:	Malinovskaya, Yulia, Melnikov, Pavel, Baklaushev, Vladimir, Gabashvili, Anna, Osipova, Nadezhda, Mantrov, Sergey, Ermolenko, Yulia, Maksimenko, Olga, Gorshkova, Marina, Balabanyan, Vadim, Kreuter, Jörg, Gelperina, Svetlana
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood-Brain Barrier Cell Line, Tumor Doxorubicin Doxorubicin - administration & dosage Drug Liberation Endocytosis Glioblastoma - drug therapy Humans Lactic Acid - chemistry Nanoparticles - chemistry PLGA nanoparticles Poloxamer 188 Polyglycolic Acid - chemistry U87 human glioma cell line
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