Autophagy Primes Neutrophils for Neutrophil Extracellular Trap Formation during Sepsis

Neutrophils are key effectors in the host's immune response to sepsis. Excessive stimulation or dysregulated neutrophil functions are believed to be responsible for sepsis pathogenesis. However, the mechanisms regulating functional plasticity of neutrophils during sepsis have not been fully det...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2017-09, Vol.196 (5), p.577-589
Hauptverfasser:	Park, So Young, Shrestha, Sanjeeb, Youn, Young-Jin, Kim, Jun-Kyu, Kim, Shin-Yeong, Kim, Hyun Jung, Park, So-Hee, Ahn, Won-Gyun, Kim, Shin, Lee, Myung Goo, Jung, Ki-Suck, Park, Yong Bum, Mo, Eun-Kyung, Ko, Yousang, Lee, Suh-Young, Koh, Younsuck, Park, Myung Jae, Song, Dong-Keun, Hong, Chang-Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer's disease Animals Autophagy Autophagy - immunology Autophagy - physiology Community-Acquired Infections - immunology Community-Acquired Infections - physiopathology Deoxyribonucleic acid Disease Models, Animal DNA Extracellular Traps - immunology Female Fluorescent Antibody Technique Humans Male Mice Mice, Inbred BALB C Mitochondrial DNA Neutrophils Neutrophils - immunology Neutrophils - physiology Pathogenesis Pneumonia Pneumonia - immunology Pneumonia - physiopathology Prospective Studies Rodents Sepsis Sepsis - immunology Sepsis - physiopathology
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