Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo

Materials that support the assembly of new vasculature are critical for regenerative medicine. Controlling the scaffold’s mechanical properties may help to optimize neovascularization within implanted biomaterials. However, reducing the stiffness of synthetic hydrogels usually requires decreasing po...

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Veröffentlicht in:	Annals of biomedical engineering 2017-06, Vol.45 (6), p.1387-1398
Hauptverfasser:	Schweller, Ryan M., Wu, Zi Jun, Klitzman, Bruce, West, Jennifer L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates Animals Biochemistry Biocompatible Materials Biological and Medical Physics Biomaterials Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedical materials Biomedicine Biophysics Cell Adhesion Chains (polymeric) Classical Mechanics Degradability Fibroblast growth factor 2 Gels Growth factors Hydrogels Hydrogels - chemistry Hydrogels - pharmacology Male Mechanical properties Neovascularization, Physiologic Peptide Hydrolases - chemistry Peptides - chemistry Peptides - pharmacology Photopolymerization Platelet-derived growth factor Platelet-derived growth factor BB Polyethylene glycol Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polymers Prostheses and Implants Proteolysis Rats, Inbred Lew Regenerative medicine Scaffolds Stiffness Surgical implants Tissue Engineering Tissues Vascularization
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