Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo
Materials that support the assembly of new vasculature are critical for regenerative medicine. Controlling the scaffold’s mechanical properties may help to optimize neovascularization within implanted biomaterials. However, reducing the stiffness of synthetic hydrogels usually requires decreasing po...
Gespeichert in:
| Veröffentlicht in: | Annals of biomedical engineering 2017-06, Vol.45 (6), p.1387-1398 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1398 |
|---|---|
| container_issue | 6 |
| container_start_page | 1387 |
| container_title | Annals of biomedical engineering |
| container_volume | 45 |
| creator | Schweller, Ryan M. Wu, Zi Jun Klitzman, Bruce West, Jennifer L. |
| description | Materials that support the assembly of new vasculature are critical for regenerative medicine. Controlling the scaffold’s mechanical properties may help to optimize neovascularization within implanted biomaterials. However, reducing the stiffness of synthetic hydrogels usually requires decreasing polymer densities or increasing chain lengths, both of which accelerate degradation. We synthesized enzymatically-degradable poly(ethylene glycol) hydrogels with compressive moduli from 2 to 18 kPa at constant polymer density, chain length, and proteolytic degradability by inserting an allyloxycarbonyl functionality into the polymer backbone. This group competes with acrylates during photopolymerization to alter the crosslink network structure and reduce the hydrogel’s stiffness. Hydrogels that incorporated (soft) or lacked (stiff) this group were implanted subcutaneously in rats to investigate the role of stiffness on host tissue interactions. Changes in tissue integration were quantified after 4 weeks
via
the hydrogel area replaced by native tissue (tissue area fraction), yielding 0.136 for softer vs. 0.062 for stiffer hydrogels. Including soluble FGF-2 and PDGF-BB improved these responses to 0.164 and 0.089, respectively. Softer gels exhibited greater vascularization with 8.6 microvessels mm
−2
compared to stiffer gels at 2.4 microvessels mm
−2
. Growth factors improved this to 11.2 and 4.9 microvessels mm
−2
, respectively. Softer hydrogels tended to display more sustained responses, promoting neovascularization and tissue integration in synthetic scaffolds. |
| doi_str_mv | 10.1007/s10439-017-1822-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1883177031</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1883177031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-f11151b98d491766a43220981777589dfd171467bc628c4c34050a3dde5291a23</originalsourceid><addsrcrecordid>eNp1kU1LHTEUhoNU6tX2B3RTAt10M5qTZPKxlItVQVSw7TbkTjJ2ZO5Ec2Yu6K83w1UpgquE5HmfHPIS8g3YITCmjxCYFLZioCswnFdmhyyg1qKyyqhPZMGYZZWySu6RfcQ7xgCMqD-TPW6EKnu-IM3N2LXtEBFpaul1TmP0GOlNHLAbu02kfgh0GfueHod_EeeT65NTevYYcrqNPc6RdQkhvYxp47GZep-7Jz92aaDnA_3bbdIXstv6HuPXl_WA_Pl18nt5Vl1cnZ4vjy-qRtZ8rFoAqGFlTZAWtFJeCs6ZNaC1ro0NbQANUulVo7hpZCMkq5kXIcSaW_BcHJCfW-99Tg9TxNGtO2zK7H6IaUIHxogiYwIK-uMdepemPJTpCmWtAin1LIQt1eSEmGPr7nO39vnRAXNzA27bgCsNuLkBZ0rm-4t5Wq1jeEu8fnkB-BbAcjXcxvzf0x9anwEcD47o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1899614472</pqid></control><display><type>article</type><title>Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Schweller, Ryan M. ; Wu, Zi Jun ; Klitzman, Bruce ; West, Jennifer L.</creator><creatorcontrib>Schweller, Ryan M. ; Wu, Zi Jun ; Klitzman, Bruce ; West, Jennifer L.</creatorcontrib><description>Materials that support the assembly of new vasculature are critical for regenerative medicine. Controlling the scaffold’s mechanical properties may help to optimize neovascularization within implanted biomaterials. However, reducing the stiffness of synthetic hydrogels usually requires decreasing polymer densities or increasing chain lengths, both of which accelerate degradation. We synthesized enzymatically-degradable poly(ethylene glycol) hydrogels with compressive moduli from 2 to 18 kPa at constant polymer density, chain length, and proteolytic degradability by inserting an allyloxycarbonyl functionality into the polymer backbone. This group competes with acrylates during photopolymerization to alter the crosslink network structure and reduce the hydrogel’s stiffness. Hydrogels that incorporated (soft) or lacked (stiff) this group were implanted subcutaneously in rats to investigate the role of stiffness on host tissue interactions. Changes in tissue integration were quantified after 4 weeks
via
the hydrogel area replaced by native tissue (tissue area fraction), yielding 0.136 for softer vs. 0.062 for stiffer hydrogels. Including soluble FGF-2 and PDGF-BB improved these responses to 0.164 and 0.089, respectively. Softer gels exhibited greater vascularization with 8.6 microvessels mm
−2
compared to stiffer gels at 2.4 microvessels mm
−2
. Growth factors improved this to 11.2 and 4.9 microvessels mm
−2
, respectively. Softer hydrogels tended to display more sustained responses, promoting neovascularization and tissue integration in synthetic scaffolds.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-017-1822-8</identifier><identifier>PMID: 28361182</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acrylates ; Animals ; Biochemistry ; Biocompatible Materials ; Biological and Medical Physics ; Biomaterials ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Biomedicine ; Biophysics ; Cell Adhesion ; Chains (polymeric) ; Classical Mechanics ; Degradability ; Fibroblast growth factor 2 ; Gels ; Growth factors ; Hydrogels ; Hydrogels - chemistry ; Hydrogels - pharmacology ; Male ; Mechanical properties ; Neovascularization, Physiologic ; Peptide Hydrolases - chemistry ; Peptides - chemistry ; Peptides - pharmacology ; Photopolymerization ; Platelet-derived growth factor ; Platelet-derived growth factor BB ; Polyethylene glycol ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - pharmacology ; Polymers ; Prostheses and Implants ; Proteolysis ; Rats, Inbred Lew ; Regenerative medicine ; Scaffolds ; Stiffness ; Surgical implants ; Tissue Engineering ; Tissues ; Vascularization</subject><ispartof>Annals of biomedical engineering, 2017-06, Vol.45 (6), p.1387-1398</ispartof><rights>Biomedical Engineering Society 2017</rights><rights>Annals of Biomedical Engineering is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-f11151b98d491766a43220981777589dfd171467bc628c4c34050a3dde5291a23</citedby><cites>FETCH-LOGICAL-c452t-f11151b98d491766a43220981777589dfd171467bc628c4c34050a3dde5291a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-017-1822-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-017-1822-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28361182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schweller, Ryan M.</creatorcontrib><creatorcontrib>Wu, Zi Jun</creatorcontrib><creatorcontrib>Klitzman, Bruce</creatorcontrib><creatorcontrib>West, Jennifer L.</creatorcontrib><title>Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>Materials that support the assembly of new vasculature are critical for regenerative medicine. Controlling the scaffold’s mechanical properties may help to optimize neovascularization within implanted biomaterials. However, reducing the stiffness of synthetic hydrogels usually requires decreasing polymer densities or increasing chain lengths, both of which accelerate degradation. We synthesized enzymatically-degradable poly(ethylene glycol) hydrogels with compressive moduli from 2 to 18 kPa at constant polymer density, chain length, and proteolytic degradability by inserting an allyloxycarbonyl functionality into the polymer backbone. This group competes with acrylates during photopolymerization to alter the crosslink network structure and reduce the hydrogel’s stiffness. Hydrogels that incorporated (soft) or lacked (stiff) this group were implanted subcutaneously in rats to investigate the role of stiffness on host tissue interactions. Changes in tissue integration were quantified after 4 weeks
via
the hydrogel area replaced by native tissue (tissue area fraction), yielding 0.136 for softer vs. 0.062 for stiffer hydrogels. Including soluble FGF-2 and PDGF-BB improved these responses to 0.164 and 0.089, respectively. Softer gels exhibited greater vascularization with 8.6 microvessels mm
−2
compared to stiffer gels at 2.4 microvessels mm
−2
. Growth factors improved this to 11.2 and 4.9 microvessels mm
−2
, respectively. Softer hydrogels tended to display more sustained responses, promoting neovascularization and tissue integration in synthetic scaffolds.</description><subject>Acrylates</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biocompatible Materials</subject><subject>Biological and Medical Physics</subject><subject>Biomaterials</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Cell Adhesion</subject><subject>Chains (polymeric)</subject><subject>Classical Mechanics</subject><subject>Degradability</subject><subject>Fibroblast growth factor 2</subject><subject>Gels</subject><subject>Growth factors</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Hydrogels - pharmacology</subject><subject>Male</subject><subject>Mechanical properties</subject><subject>Neovascularization, Physiologic</subject><subject>Peptide Hydrolases - chemistry</subject><subject>Peptides - chemistry</subject><subject>Peptides - pharmacology</subject><subject>Photopolymerization</subject><subject>Platelet-derived growth factor</subject><subject>Platelet-derived growth factor BB</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Polymers</subject><subject>Prostheses and Implants</subject><subject>Proteolysis</subject><subject>Rats, Inbred Lew</subject><subject>Regenerative medicine</subject><subject>Scaffolds</subject><subject>Stiffness</subject><subject>Surgical implants</subject><subject>Tissue Engineering</subject><subject>Tissues</subject><subject>Vascularization</subject><issn>0090-6964</issn><issn>1573-9686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1LHTEUhoNU6tX2B3RTAt10M5qTZPKxlItVQVSw7TbkTjJ2ZO5Ec2Yu6K83w1UpgquE5HmfHPIS8g3YITCmjxCYFLZioCswnFdmhyyg1qKyyqhPZMGYZZWySu6RfcQ7xgCMqD-TPW6EKnu-IM3N2LXtEBFpaul1TmP0GOlNHLAbu02kfgh0GfueHod_EeeT65NTevYYcrqNPc6RdQkhvYxp47GZep-7Jz92aaDnA_3bbdIXstv6HuPXl_WA_Pl18nt5Vl1cnZ4vjy-qRtZ8rFoAqGFlTZAWtFJeCs6ZNaC1ro0NbQANUulVo7hpZCMkq5kXIcSaW_BcHJCfW-99Tg9TxNGtO2zK7H6IaUIHxogiYwIK-uMdepemPJTpCmWtAin1LIQt1eSEmGPr7nO39vnRAXNzA27bgCsNuLkBZ0rm-4t5Wq1jeEu8fnkB-BbAcjXcxvzf0x9anwEcD47o</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Schweller, Ryan M.</creator><creator>Wu, Zi Jun</creator><creator>Klitzman, Bruce</creator><creator>West, Jennifer L.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo</title><author>Schweller, Ryan M. ; Wu, Zi Jun ; Klitzman, Bruce ; West, Jennifer L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-f11151b98d491766a43220981777589dfd171467bc628c4c34050a3dde5291a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acrylates</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biocompatible Materials</topic><topic>Biological and Medical Physics</topic><topic>Biomaterials</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedical materials</topic><topic>Biomedicine</topic><topic>Biophysics</topic><topic>Cell Adhesion</topic><topic>Chains (polymeric)</topic><topic>Classical Mechanics</topic><topic>Degradability</topic><topic>Fibroblast growth factor 2</topic><topic>Gels</topic><topic>Growth factors</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Hydrogels - pharmacology</topic><topic>Male</topic><topic>Mechanical properties</topic><topic>Neovascularization, Physiologic</topic><topic>Peptide Hydrolases - chemistry</topic><topic>Peptides - chemistry</topic><topic>Peptides - pharmacology</topic><topic>Photopolymerization</topic><topic>Platelet-derived growth factor</topic><topic>Platelet-derived growth factor BB</topic><topic>Polyethylene glycol</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Polymers</topic><topic>Prostheses and Implants</topic><topic>Proteolysis</topic><topic>Rats, Inbred Lew</topic><topic>Regenerative medicine</topic><topic>Scaffolds</topic><topic>Stiffness</topic><topic>Surgical implants</topic><topic>Tissue Engineering</topic><topic>Tissues</topic><topic>Vascularization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schweller, Ryan M.</creatorcontrib><creatorcontrib>Wu, Zi Jun</creatorcontrib><creatorcontrib>Klitzman, Bruce</creatorcontrib><creatorcontrib>West, Jennifer L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of biomedical engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schweller, Ryan M.</au><au>Wu, Zi Jun</au><au>Klitzman, Bruce</au><au>West, Jennifer L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo</atitle><jtitle>Annals of biomedical engineering</jtitle><stitle>Ann Biomed Eng</stitle><addtitle>Ann Biomed Eng</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>45</volume><issue>6</issue><spage>1387</spage><epage>1398</epage><pages>1387-1398</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>Materials that support the assembly of new vasculature are critical for regenerative medicine. Controlling the scaffold’s mechanical properties may help to optimize neovascularization within implanted biomaterials. However, reducing the stiffness of synthetic hydrogels usually requires decreasing polymer densities or increasing chain lengths, both of which accelerate degradation. We synthesized enzymatically-degradable poly(ethylene glycol) hydrogels with compressive moduli from 2 to 18 kPa at constant polymer density, chain length, and proteolytic degradability by inserting an allyloxycarbonyl functionality into the polymer backbone. This group competes with acrylates during photopolymerization to alter the crosslink network structure and reduce the hydrogel’s stiffness. Hydrogels that incorporated (soft) or lacked (stiff) this group were implanted subcutaneously in rats to investigate the role of stiffness on host tissue interactions. Changes in tissue integration were quantified after 4 weeks
via
the hydrogel area replaced by native tissue (tissue area fraction), yielding 0.136 for softer vs. 0.062 for stiffer hydrogels. Including soluble FGF-2 and PDGF-BB improved these responses to 0.164 and 0.089, respectively. Softer gels exhibited greater vascularization with 8.6 microvessels mm
−2
compared to stiffer gels at 2.4 microvessels mm
−2
. Growth factors improved this to 11.2 and 4.9 microvessels mm
−2
, respectively. Softer hydrogels tended to display more sustained responses, promoting neovascularization and tissue integration in synthetic scaffolds.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28361182</pmid><doi>10.1007/s10439-017-1822-8</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-6964 |
| ispartof | Annals of biomedical engineering, 2017-06, Vol.45 (6), p.1387-1398 |
| issn | 0090-6964 1573-9686 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1883177031 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acrylates Animals Biochemistry Biocompatible Materials Biological and Medical Physics Biomaterials Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedical materials Biomedicine Biophysics Cell Adhesion Chains (polymeric) Classical Mechanics Degradability Fibroblast growth factor 2 Gels Growth factors Hydrogels Hydrogels - chemistry Hydrogels - pharmacology Male Mechanical properties Neovascularization, Physiologic Peptide Hydrolases - chemistry Peptides - chemistry Peptides - pharmacology Photopolymerization Platelet-derived growth factor Platelet-derived growth factor BB Polyethylene glycol Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polymers Prostheses and Implants Proteolysis Rats, Inbred Lew Regenerative medicine Scaffolds Stiffness Surgical implants Tissue Engineering Tissues Vascularization |
| title | Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T09%3A38%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stiffness%20of%20Protease%20Sensitive%20and%20Cell%20Adhesive%20PEG%20Hydrogels%20Promotes%20Neovascularization%20In%20Vivo&rft.jtitle=Annals%20of%20biomedical%20engineering&rft.au=Schweller,%20Ryan%20M.&rft.date=2017-06-01&rft.volume=45&rft.issue=6&rft.spage=1387&rft.epage=1398&rft.pages=1387-1398&rft.issn=0090-6964&rft.eissn=1573-9686&rft_id=info:doi/10.1007/s10439-017-1822-8&rft_dat=%3Cproquest_cross%3E1883177031%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1899614472&rft_id=info:pmid/28361182&rfr_iscdi=true |