Alleviating the Suppression of Glycogen Synthase Kinase-3β by Akt Leads to the Phosphorylation of cAMP-response Element-binding Protein and Its Transactivation in Intact Cell Nuclei

Glycogen synthase kinase-3β (GSK-3β) activity is suppressed when it becomes phosphorylated on serine 9 by protein kinase B (Akt). To determine how GSK-3β activity opposes Akt function we used various methods to alleviate GSK-3β suppression in prostate carcinoma cells. In some experiments, LY294002,...

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Veröffentlicht in:	The Journal of biological chemistry 2003-10, Vol.278 (42), p.41338-41346
Hauptverfasser:	Salas, Thomas R., Reddy, Shrikanth A., Clifford, John L., Davis, Roger J., Kikuchi, Akira, Lippman, Scott M., Menter, David G.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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