Metabolic Activation of 2-Hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian Hamsters Congenic at the N-Acetyltransferase 2 (NAT2) Locus

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine carcinogen prevalent in the human diet. To exert its mutagenic and carcinogenic effects, PhIP undergoes bioactivation to N-hydroxy-PhIP followed by O-esterification via cytosolic acetyltransferases or sulfotransferases to...

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Veröffentlicht in:	Toxicological sciences 2003-08, Vol.74 (2), p.253-259
Hauptverfasser:	Fretland, Adrian J., Devanaboyina, Uday S., Doll, Mark A., Zhao, Shuang, Xiao, Gong H., Hein, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-amino-1-methyl-6-phenylimidazo 2-hydroxyamino-1-methyl-6-phenylimidazo 5-b]pyridine (N-hydroxy-PhIP) 5-b]pyridine (PhIP) Acetylation acetylator genotype Animals Animals, Congenic Arylamine N-Acetyltransferase - genetics Arylamine N-Acetyltransferase - metabolism Biological and medical sciences Biotransformation Carcinogenesis, carcinogens and anticarcinogens Carcinogens - pharmacokinetics Carcinogens - toxicity Chemical agents Cricetinae Cytosol - drug effects Cytosol - enzymology DNA - drug effects DNA adducts DNA Adducts - analysis DNA Adducts - drug effects Genotype Imidazoles - pharmacokinetics Imidazoles - toxicity Male Medical sciences Mesocricetus N-acetyltransferase 2 (NAT2) Polymorphism, Genetic Pyridines - pharmacokinetics Pyridines - toxicity Syrian hamster Tumors
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