Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

Although many aspects of blood production are well understood, the spatial organization of myeloid differentiation in the bone marrow remains unknown. Here we use imaging to track granulocyte/macrophage progenitor (GMP) behaviour in mice during emergency and leukaemic myelopoiesis. In the steady sta...

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Veröffentlicht in:	Nature (London) 2017-04, Vol.544 (7648), p.53-58
Hauptverfasser:	Hérault, Aurélie, Binnewies, Mikhail, Leong, Stephanie, Calero-Nieto, Fernando J., Zhang, Si Yi, Kang, Yoon-A, Wang, Xiaonan, Pietras, Eric M., Chu, S. Haihua, Barry-Holson, Keegan, Armstrong, Scott, Göttgens, Berthold, Passegué, Emmanuelle
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/21 13/31 14 14/1 38 38/91 631/532/1542 631/532/2139 631/532/489 631/532/71 631/67/1990/283 64 64/60 Animals beta Catenin - metabolism Biology Bone marrow Cell cycle Cell Self Renewal Cellular Reprogramming Cytokines Cytokines - metabolism Granulocyte-Macrophage Progenitor Cells - cytology Granulocyte-Macrophage Progenitor Cells - pathology Granulocytes Granulocytes - cytology Granulocytes - pathology Humanities and Social Sciences Interferon Regulatory Factors - metabolism Leukemia Leukemia - pathology Macrophages - cytology Macrophages - pathology Mice Molecular Imaging multidisciplinary Myelopoiesis Neoplastic Stem Cells - pathology Physiological aspects Rodents Science Stem Cell Niche - physiology
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