Measurement of Dioxins in Human Blood: Improvement of Analytical Method
We have improved the method of measuring dioxins in the blood of Yusho patients; with this improved method, it is possible to take measurements quickly and precisely, using as little as 5g of blood. The specific points of improvement of this method are the extraction of lipids from blood by accelera...
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| Veröffentlicht in: | Industrial Health 2003, Vol.41(3), pp.197-204 |
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| container_title | Industrial Health |
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| creator | IIDA, Takao TODAKA, Takashi |
| description | We have improved the method of measuring dioxins in the blood of Yusho patients; with this improved method, it is possible to take measurements quickly and precisely, using as little as 5g of blood. The specific points of improvement of this method are the extraction of lipids from blood by accelerated solvent extractor (ASE), the miniaturization of column cleanup for the purification of dioxins, and the use of a solvent cut large volume (SCLV) injection system with high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Using this improved method of analysis, we are currently investigating dioxins in the blood of 400 Yusho patients collected in Japan in 2002. We here describe the details of our announcement at Dioxin 2002 Symposium about the improvement of this analysis method, and discuss several other modifications |
| doi_str_mv | 10.2486/indhealth.41.197 |
| format | Article |
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The specific points of improvement of this method are the extraction of lipids from blood by accelerated solvent extractor (ASE), the miniaturization of column cleanup for the purification of dioxins, and the use of a solvent cut large volume (SCLV) injection system with high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Using this improved method of analysis, we are currently investigating dioxins in the blood of 400 Yusho patients collected in Japan in 2002. We here describe the details of our announcement at Dioxin 2002 Symposium about the improvement of this analysis method, and discuss several other modifications</description><identifier>ISSN: 0019-8366</identifier><identifier>EISSN: 1880-8026</identifier><identifier>DOI: 10.2486/indhealth.41.197</identifier><identifier>PMID: 12916750</identifier><language>eng</language><publisher>Japan: National Institute of Occupational Safety and Health</publisher><subject>Accelerated solvent extraction (ASE) ; Benzofurans - blood ; Blood ; Coplanar PCBs ; Dibenzofurans, Polychlorinated ; Dioxins - blood ; Environmental Exposure - analysis ; Gas Chromatography-Mass Spectrometry - methods ; Gas Chromatography-Mass Spectrometry - standards ; HRGC/HRMS ; Humans ; Japan ; Miniaturization ; PCDDs ; PCDFs ; Polychlorinated Dibenzodioxins - analogs & derivatives ; Polychlorinated Dibenzodioxins - blood ; Solvent cut large volume (SCLV) injection system ; Yusho</subject><ispartof>Industrial Health, 2003, Vol.41(3), pp.197-204</ispartof><rights>National Institute of Occupational Safety and Health</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-e2a169b1501b542d42f0a56e25ae591ce52ca73ca498c16c40273656d8b67cac3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12916750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IIDA, Takao</creatorcontrib><creatorcontrib>TODAKA, Takashi</creatorcontrib><title>Measurement of Dioxins in Human Blood: Improvement of Analytical Method</title><title>Industrial Health</title><addtitle>Ind Health</addtitle><description>We have improved the method of measuring dioxins in the blood of Yusho patients; with this improved method, it is possible to take measurements quickly and precisely, using as little as 5g of blood. 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| ispartof | Industrial Health, 2003, Vol.41(3), pp.197-204 |
| issn | 0019-8366 1880-8026 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Accelerated solvent extraction (ASE) Benzofurans - blood Blood Coplanar PCBs Dibenzofurans, Polychlorinated Dioxins - blood Environmental Exposure - analysis Gas Chromatography-Mass Spectrometry - methods Gas Chromatography-Mass Spectrometry - standards HRGC/HRMS Humans Japan Miniaturization PCDDs PCDFs Polychlorinated Dibenzodioxins - analogs & derivatives Polychlorinated Dibenzodioxins - blood Solvent cut large volume (SCLV) injection system Yusho |
| title | Measurement of Dioxins in Human Blood: Improvement of Analytical Method |
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