A longitudinal DTI and histological study of the spinal cord reveals early pathological alterations in G93A-SOD1 mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective motor neuron degeneration in the motor cortex, brainstem and spinal cord. It is generally accepted that ALS is caused by death of motor neurons, however the exact temporal cascade of degenerative processes...

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Veröffentlicht in:	Experimental neurology 2017-07, Vol.293, p.43-52
Hauptverfasser:	Marcuzzo, Stefania, Bonanno, Silvia, Figini, Matteo, Scotti, Alessandro, Zucca, Ileana, Minati, Ludovico, Riva, Nilo, Domi, Teuta, Fossaghi, Andrea, Quattrini, Angelo, Galbardi, Barbara, D'Alessandro, Sara, Bruzzone, Maria Grazia, García-Verdugo, José Manuel, Moreno-Manzano, Victoria, Mantegazza, Renato, Bernasconi, Pia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - diagnostic imaging Amyotrophic Lateral Sclerosis - genetics Animals Anthracenes Axon degeneration Diffusion Tensor Imaging Disease Models, Animal Electron microscopy G93A-SOD1 mice Gray Matter - diagnostic imaging Gray Matter - ultrastructure Humans Image Processing, Computer-Assisted Magnetic resonance imaging Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Electron, Transmission Mitochondria - pathology Mitochondria - ultrastructure Motor neuron diseases Sensory Receptor Cells - pathology Sensory Receptor Cells - ultrastructure Spinal Cord - diagnostic imaging Spinal Cord - pathology Spinal Cord - ultrastructure Superoxide Dismutase - genetics Time Factors White Matter - diagnostic imaging White Matter - ultrastructure
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