Comparing the Administration of Letrozole and Megestrol Acetate in the Treatment of Women with Simple Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial
Introduction The present study was conducted as a pilot to compare the therapeutic effects and the potential side effects of oral Megestrol acetate and Letrozole in the treatment of simple hyperplasia in perimenopausal women. Methods The participants of this randomized clinical trial consisted of tw...
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| Veröffentlicht in: | Advances in therapy 2017-05, Vol.34 (5), p.1211-1220 |
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| creator | Moradan, Sanam Nikkhah, Niaz Mirmohammadkhanai, Majid |
| description | Introduction
The present study was conducted as a pilot to compare the therapeutic effects and the potential side effects of oral Megestrol acetate and Letrozole in the treatment of simple hyperplasia in perimenopausal women.
Methods
The participants of this randomized clinical trial consisted of two groups of 25 women aged 44–50 presenting with abnormal uterine bleeding diagnosed with simple endometrial hyperplasia without cytologic atypia confirmed by transvaginal ultrasonography and biopsy. The first group received 40-mg doses of Megestrol acetate for 2 weeks per month for a total period of 2 months. The second group received 2.5-mg daily doses of Letrozole for a total period of 2 months. The differences in terms of quantitative measurements were analyzed using the independent two-sample
t
test and the paired
t
test. To compare the two groups in terms of the distribution of the categorical variables, Pearson’s Chi square and Fisher’s Exact tests were used at the significance level of 0.05 by Stata-9.2.
Results
Although the intervention led to significant improvements in both groups (
P
|
| doi_str_mv | 10.1007/s12325-017-0509-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1882079642</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1882079642</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-151911c6f4ac4092e7dc899c75c0d21dc3c9c69a4c663ed42e86fa3d3c1afd243</originalsourceid><addsrcrecordid>eNp9kctu1DAUhi1ERYfCA7BBXrIJ-JbEYReNekEahFQGwc4y9knrKrGD7aiavhFvidMpLFlYtuzvOzrHP0JvKHlPCWk_JMo4qytC24rUpKvkM7ShsqmrsthztCGtoBXj8scpepnSHSGMtLV8gU6Z5DWnQmzQ722YZh2dv8H5FnBvJ-ddylFnFzwOA95BjuEhjIC1t_gz3EB5DSPuDWSdATv_KO4j6DyBz6vzPZQTvnf5Fn9101zcc2_LXY5Oj_jqMEOcR52cfmTCknGfD7PTH3GPr_WKugeweDuWXkwx9qv3Cp0Mekzw-mk_Q98uzvfbq2r35fLTtt9VRlCRK1rTjlLTDEIbQToGrTWy60xbG2IZtYabzjSdFqZpOFjBQDaD5pYbqgfLBD9D74515xh-LWVaNblkYBy1h7AkRaUs39g1ghWUHlETQ0oRBjVHN-l4UJSoNSF1TEiVhNSakJLFeftUfvk5gf1n_I2kAOwIpHmNBaK6C0v0ZeT_VP0D996fQA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1882079642</pqid></control><display><type>article</type><title>Comparing the Administration of Letrozole and Megestrol Acetate in the Treatment of Women with Simple Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Moradan, Sanam ; Nikkhah, Niaz ; Mirmohammadkhanai, Majid</creator><creatorcontrib>Moradan, Sanam ; Nikkhah, Niaz ; Mirmohammadkhanai, Majid</creatorcontrib><description>Introduction
The present study was conducted as a pilot to compare the therapeutic effects and the potential side effects of oral Megestrol acetate and Letrozole in the treatment of simple hyperplasia in perimenopausal women.
Methods
The participants of this randomized clinical trial consisted of two groups of 25 women aged 44–50 presenting with abnormal uterine bleeding diagnosed with simple endometrial hyperplasia without cytologic atypia confirmed by transvaginal ultrasonography and biopsy. The first group received 40-mg doses of Megestrol acetate for 2 weeks per month for a total period of 2 months. The second group received 2.5-mg daily doses of Letrozole for a total period of 2 months. The differences in terms of quantitative measurements were analyzed using the independent two-sample
t
test and the paired
t
test. To compare the two groups in terms of the distribution of the categorical variables, Pearson’s Chi square and Fisher’s Exact tests were used at the significance level of 0.05 by Stata-9.2.
Results
Although the intervention led to significant improvements in both groups (
P
< .001), there was no difference between the groups in terms of accomplishing resolution (
P
= .74) [seven (28%) patients in the Letrozole group and five (20%) in the Megestrol group], while two patients in the Letrozole group and nine in the Megestrol group suffered from side effects, suggesting significantly lower side effects in the Letrozole group (
P
= .02).
Conclusion
Letrozole and Megestrol acetate seem to have similar effects on the treatment of simple endometrial hyperplasia, the only difference being that Letrozole presents fewer side effects than Megestrol acetate in patients with this condition.
Funding
Abnormal Uterine Bleeding Research Center of Semnan University of Medical Sciences, Semnan, Iran.
Trial Registration
: IRCT2015031011504N5</description><identifier>ISSN: 0741-238X</identifier><identifier>EISSN: 1865-8652</identifier><identifier>DOI: 10.1007/s12325-017-0509-8</identifier><identifier>PMID: 28353144</identifier><language>eng</language><publisher>Cheshire: Springer Healthcare</publisher><subject>Administration, Oral ; Adult ; Cardiology ; Endocrinology ; Endometrial Hyperplasia - drug therapy ; Female ; Health technology assessment ; Humans ; Internal Medicine ; IRCT ; IRCT2015031011504N5 ; Medicine ; Medicine & Public Health ; Megestrol Acetate - therapeutic use ; Middle Aged ; Nitriles - therapeutic use ; Oncology ; Original Research ; Pharmacology/Toxicology ; Pilot Projects ; Rheumatology ; Triazoles - therapeutic use</subject><ispartof>Advances in therapy, 2017-05, Vol.34 (5), p.1211-1220</ispartof><rights>Springer Healthcare 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-151911c6f4ac4092e7dc899c75c0d21dc3c9c69a4c663ed42e86fa3d3c1afd243</citedby><cites>FETCH-LOGICAL-c414t-151911c6f4ac4092e7dc899c75c0d21dc3c9c69a4c663ed42e86fa3d3c1afd243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12325-017-0509-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12325-017-0509-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28353144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moradan, Sanam</creatorcontrib><creatorcontrib>Nikkhah, Niaz</creatorcontrib><creatorcontrib>Mirmohammadkhanai, Majid</creatorcontrib><title>Comparing the Administration of Letrozole and Megestrol Acetate in the Treatment of Women with Simple Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial</title><title>Advances in therapy</title><addtitle>Adv Ther</addtitle><addtitle>Adv Ther</addtitle><description>Introduction
The present study was conducted as a pilot to compare the therapeutic effects and the potential side effects of oral Megestrol acetate and Letrozole in the treatment of simple hyperplasia in perimenopausal women.
Methods
The participants of this randomized clinical trial consisted of two groups of 25 women aged 44–50 presenting with abnormal uterine bleeding diagnosed with simple endometrial hyperplasia without cytologic atypia confirmed by transvaginal ultrasonography and biopsy. The first group received 40-mg doses of Megestrol acetate for 2 weeks per month for a total period of 2 months. The second group received 2.5-mg daily doses of Letrozole for a total period of 2 months. The differences in terms of quantitative measurements were analyzed using the independent two-sample
t
test and the paired
t
test. To compare the two groups in terms of the distribution of the categorical variables, Pearson’s Chi square and Fisher’s Exact tests were used at the significance level of 0.05 by Stata-9.2.
Results
Although the intervention led to significant improvements in both groups (
P
< .001), there was no difference between the groups in terms of accomplishing resolution (
P
= .74) [seven (28%) patients in the Letrozole group and five (20%) in the Megestrol group], while two patients in the Letrozole group and nine in the Megestrol group suffered from side effects, suggesting significantly lower side effects in the Letrozole group (
P
= .02).
Conclusion
Letrozole and Megestrol acetate seem to have similar effects on the treatment of simple endometrial hyperplasia, the only difference being that Letrozole presents fewer side effects than Megestrol acetate in patients with this condition.
Funding
Abnormal Uterine Bleeding Research Center of Semnan University of Medical Sciences, Semnan, Iran.
Trial Registration
: IRCT2015031011504N5</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Cardiology</subject><subject>Endocrinology</subject><subject>Endometrial Hyperplasia - drug therapy</subject><subject>Female</subject><subject>Health technology assessment</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>IRCT</subject><subject>IRCT2015031011504N5</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Megestrol Acetate - therapeutic use</subject><subject>Middle Aged</subject><subject>Nitriles - therapeutic use</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Pilot Projects</subject><subject>Rheumatology</subject><subject>Triazoles - therapeutic use</subject><issn>0741-238X</issn><issn>1865-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUhi1ERYfCA7BBXrIJ-JbEYReNekEahFQGwc4y9knrKrGD7aiavhFvidMpLFlYtuzvOzrHP0JvKHlPCWk_JMo4qytC24rUpKvkM7ShsqmrsthztCGtoBXj8scpepnSHSGMtLV8gU6Z5DWnQmzQ722YZh2dv8H5FnBvJ-ddylFnFzwOA95BjuEhjIC1t_gz3EB5DSPuDWSdATv_KO4j6DyBz6vzPZQTvnf5Fn9101zcc2_LXY5Oj_jqMEOcR52cfmTCknGfD7PTH3GPr_WKugeweDuWXkwx9qv3Cp0Mekzw-mk_Q98uzvfbq2r35fLTtt9VRlCRK1rTjlLTDEIbQToGrTWy60xbG2IZtYabzjSdFqZpOFjBQDaD5pYbqgfLBD9D74515xh-LWVaNblkYBy1h7AkRaUs39g1ghWUHlETQ0oRBjVHN-l4UJSoNSF1TEiVhNSakJLFeftUfvk5gf1n_I2kAOwIpHmNBaK6C0v0ZeT_VP0D996fQA</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Moradan, Sanam</creator><creator>Nikkhah, Niaz</creator><creator>Mirmohammadkhanai, Majid</creator><general>Springer Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>Comparing the Administration of Letrozole and Megestrol Acetate in the Treatment of Women with Simple Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial</title><author>Moradan, Sanam ; Nikkhah, Niaz ; Mirmohammadkhanai, Majid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-151911c6f4ac4092e7dc899c75c0d21dc3c9c69a4c663ed42e86fa3d3c1afd243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Cardiology</topic><topic>Endocrinology</topic><topic>Endometrial Hyperplasia - drug therapy</topic><topic>Female</topic><topic>Health technology assessment</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>IRCT</topic><topic>IRCT2015031011504N5</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Megestrol Acetate - therapeutic use</topic><topic>Middle Aged</topic><topic>Nitriles - therapeutic use</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Pilot Projects</topic><topic>Rheumatology</topic><topic>Triazoles - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moradan, Sanam</creatorcontrib><creatorcontrib>Nikkhah, Niaz</creatorcontrib><creatorcontrib>Mirmohammadkhanai, Majid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advances in therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moradan, Sanam</au><au>Nikkhah, Niaz</au><au>Mirmohammadkhanai, Majid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparing the Administration of Letrozole and Megestrol Acetate in the Treatment of Women with Simple Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial</atitle><jtitle>Advances in therapy</jtitle><stitle>Adv Ther</stitle><addtitle>Adv Ther</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>34</volume><issue>5</issue><spage>1211</spage><epage>1220</epage><pages>1211-1220</pages><issn>0741-238X</issn><eissn>1865-8652</eissn><abstract>Introduction
The present study was conducted as a pilot to compare the therapeutic effects and the potential side effects of oral Megestrol acetate and Letrozole in the treatment of simple hyperplasia in perimenopausal women.
Methods
The participants of this randomized clinical trial consisted of two groups of 25 women aged 44–50 presenting with abnormal uterine bleeding diagnosed with simple endometrial hyperplasia without cytologic atypia confirmed by transvaginal ultrasonography and biopsy. The first group received 40-mg doses of Megestrol acetate for 2 weeks per month for a total period of 2 months. The second group received 2.5-mg daily doses of Letrozole for a total period of 2 months. The differences in terms of quantitative measurements were analyzed using the independent two-sample
t
test and the paired
t
test. To compare the two groups in terms of the distribution of the categorical variables, Pearson’s Chi square and Fisher’s Exact tests were used at the significance level of 0.05 by Stata-9.2.
Results
Although the intervention led to significant improvements in both groups (
P
< .001), there was no difference between the groups in terms of accomplishing resolution (
P
= .74) [seven (28%) patients in the Letrozole group and five (20%) in the Megestrol group], while two patients in the Letrozole group and nine in the Megestrol group suffered from side effects, suggesting significantly lower side effects in the Letrozole group (
P
= .02).
Conclusion
Letrozole and Megestrol acetate seem to have similar effects on the treatment of simple endometrial hyperplasia, the only difference being that Letrozole presents fewer side effects than Megestrol acetate in patients with this condition.
Funding
Abnormal Uterine Bleeding Research Center of Semnan University of Medical Sciences, Semnan, Iran.
Trial Registration
: IRCT2015031011504N5</abstract><cop>Cheshire</cop><pub>Springer Healthcare</pub><pmid>28353144</pmid><doi>10.1007/s12325-017-0509-8</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Administration, Oral Adult Cardiology Endocrinology Endometrial Hyperplasia - drug therapy Female Health technology assessment Humans Internal Medicine IRCT IRCT2015031011504N5 Medicine Medicine & Public Health Megestrol Acetate - therapeutic use Middle Aged Nitriles - therapeutic use Oncology Original Research Pharmacology/Toxicology Pilot Projects Rheumatology Triazoles - therapeutic use |
| title | Comparing the Administration of Letrozole and Megestrol Acetate in the Treatment of Women with Simple Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial |
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