Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: role of size and surface properties
The aim of this study was to investigate the role of particle number, total surface area, mass and surface chemical groups in ( K f,c ) changes. The lung effects of four different fine (110 nm) and ultrafine (24 nm) polystyrene particles have been tested in an isolated perfused rabbit lung model. Pu...
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| Veröffentlicht in: | Toxicology and applied pharmacology 2003-08, Vol.190 (3), p.278-285 |
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| creator | Hamoir, J Nemmar, A Halloy, D Wirth, D Vincke, G Vanderplasschen, A Nemery, B Gustin, P |
| description | The aim of this study was to investigate the role of particle number, total surface area, mass and surface chemical groups in (
K
f,c
) changes. The lung effects of four different fine (110 nm) and ultrafine (24 nm) polystyrene particles have been tested in an isolated perfused rabbit lung model. Pulmonary microvascular permeability (
K
f,c
) modifications were measured in response to intratracheal particle challenge. Polystyrene particles, mainly located in alveolar spaces and macrophages, induced a
K
f,c
increase that was related to the total surface area and number of particles rather than to the instilled mass. Moreover, the positively charged amine-modified polystyrene particles were more effective in the
K
f,c
response than the negatively charged carboxylate-modified polystyrene particles. We concluded that particle number and diameter that mathematically equally determined total surface area do not have the same importance in explaining the biological effects observed and that particle number could be an alternative to total surface area to describe the particle exposure. Furthermore, surface properties of polystyrene particles need to be considered to investigate the microvascular permeability changes measured in our model. |
| doi_str_mv | 10.1016/S0041-008X(03)00192-3 |
| format | Article |
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K
f,c
) changes. The lung effects of four different fine (110 nm) and ultrafine (24 nm) polystyrene particles have been tested in an isolated perfused rabbit lung model. Pulmonary microvascular permeability (
K
f,c
) modifications were measured in response to intratracheal particle challenge. Polystyrene particles, mainly located in alveolar spaces and macrophages, induced a
K
f,c
increase that was related to the total surface area and number of particles rather than to the instilled mass. Moreover, the positively charged amine-modified polystyrene particles were more effective in the
K
f,c
response than the negatively charged carboxylate-modified polystyrene particles. We concluded that particle number and diameter that mathematically equally determined total surface area do not have the same importance in explaining the biological effects observed and that particle number could be an alternative to total surface area to describe the particle exposure. Furthermore, surface properties of polystyrene particles need to be considered to investigate the microvascular permeability changes measured in our model.</description><identifier>ISSN: 0041-008X</identifier><identifier>EISSN: 1096-0333</identifier><identifier>DOI: 10.1016/S0041-008X(03)00192-3</identifier><identifier>PMID: 12902199</identifier><identifier>CODEN: TXAPA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Air ; Animals ; Biological and medical sciences ; Capillary Permeability - drug effects ; Environmental pollutants toxicology ; In Vitro Techniques ; Intubation, Intratracheal ; Latex particles ; Lung ; Lung - blood supply ; Lung - pathology ; Medical sciences ; Microcirculation - drug effects ; Microvascular permeability ; Particle Size ; Perfusion ; Polystyrenes ; Polystyrenes - administration & dosage ; Polystyrenes - toxicity ; Rabbits ; Surface Properties ; Toxicology ; Ultrafine</subject><ispartof>Toxicology and applied pharmacology, 2003-08, Vol.190 (3), p.278-285</ispartof><rights>2003 Elsevier Science (USA)</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-d3837e82b727dfb709e269b9e7cda97937c14fcc205c9a984e534c60e70e70b13</citedby><cites>FETCH-LOGICAL-c422t-d3837e82b727dfb709e269b9e7cda97937c14fcc205c9a984e534c60e70e70b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041008X03001923$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15043693$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12902199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamoir, J</creatorcontrib><creatorcontrib>Nemmar, A</creatorcontrib><creatorcontrib>Halloy, D</creatorcontrib><creatorcontrib>Wirth, D</creatorcontrib><creatorcontrib>Vincke, G</creatorcontrib><creatorcontrib>Vanderplasschen, A</creatorcontrib><creatorcontrib>Nemery, B</creatorcontrib><creatorcontrib>Gustin, P</creatorcontrib><title>Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: role of size and surface properties</title><title>Toxicology and applied pharmacology</title><addtitle>Toxicol Appl Pharmacol</addtitle><description>The aim of this study was to investigate the role of particle number, total surface area, mass and surface chemical groups in (
K
f,c
) changes. The lung effects of four different fine (110 nm) and ultrafine (24 nm) polystyrene particles have been tested in an isolated perfused rabbit lung model. Pulmonary microvascular permeability (
K
f,c
) modifications were measured in response to intratracheal particle challenge. Polystyrene particles, mainly located in alveolar spaces and macrophages, induced a
K
f,c
increase that was related to the total surface area and number of particles rather than to the instilled mass. Moreover, the positively charged amine-modified polystyrene particles were more effective in the
K
f,c
response than the negatively charged carboxylate-modified polystyrene particles. We concluded that particle number and diameter that mathematically equally determined total surface area do not have the same importance in explaining the biological effects observed and that particle number could be an alternative to total surface area to describe the particle exposure. Furthermore, surface properties of polystyrene particles need to be considered to investigate the microvascular permeability changes measured in our model.</description><subject>Air</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Capillary Permeability - drug effects</subject><subject>Environmental pollutants toxicology</subject><subject>In Vitro Techniques</subject><subject>Intubation, Intratracheal</subject><subject>Latex particles</subject><subject>Lung</subject><subject>Lung - blood supply</subject><subject>Lung - pathology</subject><subject>Medical sciences</subject><subject>Microcirculation - drug effects</subject><subject>Microvascular permeability</subject><subject>Particle Size</subject><subject>Perfusion</subject><subject>Polystyrenes</subject><subject>Polystyrenes - administration & dosage</subject><subject>Polystyrenes - toxicity</subject><subject>Rabbits</subject><subject>Surface Properties</subject><subject>Toxicology</subject><subject>Ultrafine</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-L1DAUxYMo7uzqR1DyoqwP1Zuk0zb7IrKsf2DBBxV8C2l6I5G0HXPThfEb-K1NZwb3UQgkkN-5JzmHsWcCXgsQzZsvALWoALrvl6BeAQgtK_WAbQTopgKl1EO2-YecsXOinwCg61o8ZmdCapBC6w37c-M9usxnz3dz3FPeJ5yQ72zKwUUkPk88LtMPPgaX5jtLbok28R2mEW0fYsh7HiYeaI4247Be-IXKIdm-D_mgpSue5oirB4XfyO00cFqSt64YpblIckB6wh55GwmfnvYL9u39zdfrj9Xt5w-frt_dVq6WMleD6lSLnexb2Q6-b0GjbHSvsXWD1a1WrRO1d07C1mmruxq3qnYNYLuuXqgL9vI4t1j_WpCyGQM5jNFOOC9kRNcJLdQKbo9g-ThRQm92KYw27Y0As3ZgDh2YNWADyhw6MKronp8Mln7E4V51Cr0AL05AidNGn-zkAt1zW6hVo9dBb48cljjuAiZDLuDkcAipdGaGOfznKX8BuxKmhA</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Hamoir, J</creator><creator>Nemmar, A</creator><creator>Halloy, D</creator><creator>Wirth, D</creator><creator>Vincke, G</creator><creator>Vanderplasschen, A</creator><creator>Nemery, B</creator><creator>Gustin, P</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20030801</creationdate><title>Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: role of size and surface properties</title><author>Hamoir, J ; Nemmar, A ; Halloy, D ; Wirth, D ; Vincke, G ; Vanderplasschen, A ; Nemery, B ; Gustin, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-d3837e82b727dfb709e269b9e7cda97937c14fcc205c9a984e534c60e70e70b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Air</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Capillary Permeability - drug effects</topic><topic>Environmental pollutants toxicology</topic><topic>In Vitro Techniques</topic><topic>Intubation, Intratracheal</topic><topic>Latex particles</topic><topic>Lung</topic><topic>Lung - blood supply</topic><topic>Lung - pathology</topic><topic>Medical sciences</topic><topic>Microcirculation - drug effects</topic><topic>Microvascular permeability</topic><topic>Particle Size</topic><topic>Perfusion</topic><topic>Polystyrenes</topic><topic>Polystyrenes - administration & dosage</topic><topic>Polystyrenes - toxicity</topic><topic>Rabbits</topic><topic>Surface Properties</topic><topic>Toxicology</topic><topic>Ultrafine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamoir, J</creatorcontrib><creatorcontrib>Nemmar, A</creatorcontrib><creatorcontrib>Halloy, D</creatorcontrib><creatorcontrib>Wirth, D</creatorcontrib><creatorcontrib>Vincke, G</creatorcontrib><creatorcontrib>Vanderplasschen, A</creatorcontrib><creatorcontrib>Nemery, B</creatorcontrib><creatorcontrib>Gustin, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamoir, J</au><au>Nemmar, A</au><au>Halloy, D</au><au>Wirth, D</au><au>Vincke, G</au><au>Vanderplasschen, A</au><au>Nemery, B</au><au>Gustin, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: role of size and surface properties</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>190</volume><issue>3</issue><spage>278</spage><epage>285</epage><pages>278-285</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><coden>TXAPA9</coden><abstract>The aim of this study was to investigate the role of particle number, total surface area, mass and surface chemical groups in (
K
f,c
) changes. The lung effects of four different fine (110 nm) and ultrafine (24 nm) polystyrene particles have been tested in an isolated perfused rabbit lung model. Pulmonary microvascular permeability (
K
f,c
) modifications were measured in response to intratracheal particle challenge. Polystyrene particles, mainly located in alveolar spaces and macrophages, induced a
K
f,c
increase that was related to the total surface area and number of particles rather than to the instilled mass. Moreover, the positively charged amine-modified polystyrene particles were more effective in the
K
f,c
response than the negatively charged carboxylate-modified polystyrene particles. We concluded that particle number and diameter that mathematically equally determined total surface area do not have the same importance in explaining the biological effects observed and that particle number could be an alternative to total surface area to describe the particle exposure. Furthermore, surface properties of polystyrene particles need to be considered to investigate the microvascular permeability changes measured in our model.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>12902199</pmid><doi>10.1016/S0041-008X(03)00192-3</doi><tpages>8</tpages></addata></record> |
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| ispartof | Toxicology and applied pharmacology, 2003-08, Vol.190 (3), p.278-285 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Air Animals Biological and medical sciences Capillary Permeability - drug effects Environmental pollutants toxicology In Vitro Techniques Intubation, Intratracheal Latex particles Lung Lung - blood supply Lung - pathology Medical sciences Microcirculation - drug effects Microvascular permeability Particle Size Perfusion Polystyrenes Polystyrenes - administration & dosage Polystyrenes - toxicity Rabbits Surface Properties Toxicology Ultrafine |
| title | Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: role of size and surface properties |
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