Polyanion based controlled release system for the GnRH-receptor antagonist degarelix

The aim of this study was to investigate the interaction between the positively charged gonadotropin releasing hormone receptor antagonist degarelix and the two polyanions alginate and carboxymethyl cellulose (CMC). Light as well as transmission electron microscopy revealed that complexes formed by...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2017-06, Vol.104, p.65-71
Hauptverfasser:	Backofen, Michael, Schwach, Gregoire, Koechling, Wolfgang, Weiss, Torsten, Goepferich, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Circular Dichroism Delayed-Action Preparations GnRH antagonist In-vitro study ITC Male Microscopy, Electron, Transmission Oligopeptides - administration & dosage Polymer complex Polymers Rats Rats, Sprague-Dawley Sustained release TEM
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