Induction of galectin-1 by TLR-dependent PI3K activation enhances epithelial-mesenchymal transition of metastatic ovarian cancer cells

The expression of different toll-like receptors (TLRs) on tumor cells has been associated with disease aggressiveness, treatment resistance, and poor prognosis. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway is considered critical for cancer cell survival and proliferation. Thus, we investigat...

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Veröffentlicht in:	Oncology reports 2017-05, Vol.37 (5), p.3137-3145
Hauptverfasser:	Park, Ga Bin, Chung, Yoon Hee, Kim, Daejin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Movement Cytokines Cytokines - genetics Cytokines - metabolism Drug resistance Enzyme Activation Epithelial-Mesenchymal Transition Female Galectin 1 - genetics Galectin 1 - metabolism galectin-1 Gene Expression Regulation, Neoplastic Humans Kinases Ligands Metastasis Neoplasm Metastasis Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Penicillin Phosphatase phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Signal Transduction SK-OV-3 Studies toll-like receptors Toll-Like Receptors - genetics Toll-Like Receptors - metabolism Treatment resistance
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