Study of N‐vinylpyrrolidone‐N‐vinylformamide copolymers labelled with indium‐113m
The procedure of the directed synthesis of N‐vinylpyrrolidone‐N‐vinylformamide (VP‐VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium‐113m were developed. The metal‐copolymer conjugates were characterized by diff...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 2017-05, Vol.60 (6), p.302-311 |
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| creator | Gorshkov, N.I. Miroslavov, А.Е. Аlekseev, I.Е. Lumpov, А.А. Мurko, А.Y. Gavrilova, I.I. Saprykina, N.N. Bezrukova, М.А. Kipper, А.I. Krasikov, V.D. Suglobov, D.N. Tyupina, M.Y. Panarin, Е.F. |
| description | The procedure of the directed synthesis of N‐vinylpyrrolidone‐N‐vinylformamide (VP‐VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium‐113m were developed. The metal‐copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high‐performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium‐113m were optimized. It was shown that the VP‐VFA‐IDA copolymer firmly binds indium‐113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP‐VFA‐IDA‐In conjugates were found to be unstable in histidine challenge reaction.
The procedure of the directed synthesis of VP‐VFA copolymers with grafted IDA chelating units was developed. Labelling the copolymer with indium‐113m was studied. Resulting conjugates were found to be unstable in interligand exchange reaction with histidine. |
| doi_str_mv | 10.1002/jlcr.3503 |
| format | Article |
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The procedure of the directed synthesis of VP‐VFA copolymers with grafted IDA chelating units was developed. Labelling the copolymer with indium‐113m was studied. Resulting conjugates were found to be unstable in interligand exchange reaction with histidine.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.3503</identifier><identifier>PMID: 28349626</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>bioconjugates ; Chelation ; Chemical synthesis ; Conjugates ; Copolymers ; Formamides - chemistry ; Graft copolymers ; High performance liquid chromatography ; Histidine ; Histidine - chemistry ; Indium ; Indium Radioisotopes - chemistry ; indium‐113m ; Labeling ; labelling ; Light scattering ; NMR ; Nuclear magnetic resonance ; N‐vinylpyrrolidone‐N‐vinylformamide copolymer ; pH effects ; Polymers - chemistry ; Pyrrolidinones - chemistry ; radiochemical synthesis ; Radiochemistry ; site specific radiopharmaceuticals ; Vinylpyrrolidone ; Viscometry</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2017-05, Vol.60 (6), p.302-311</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-f5026eb178739c33bbcb0de1ef504cc616408528763fa6ac33c2c3173fe588eb3</citedby><cites>FETCH-LOGICAL-c3533-f5026eb178739c33bbcb0de1ef504cc616408528763fa6ac33c2c3173fe588eb3</cites><orcidid>0000-0003-0150-3040</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjlcr.3503$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjlcr.3503$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28349626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorshkov, N.I.</creatorcontrib><creatorcontrib>Miroslavov, А.Е.</creatorcontrib><creatorcontrib>Аlekseev, I.Е.</creatorcontrib><creatorcontrib>Lumpov, А.А.</creatorcontrib><creatorcontrib>Мurko, А.Y.</creatorcontrib><creatorcontrib>Gavrilova, I.I.</creatorcontrib><creatorcontrib>Saprykina, N.N.</creatorcontrib><creatorcontrib>Bezrukova, М.А.</creatorcontrib><creatorcontrib>Kipper, А.I.</creatorcontrib><creatorcontrib>Krasikov, V.D.</creatorcontrib><creatorcontrib>Suglobov, D.N.</creatorcontrib><creatorcontrib>Tyupina, M.Y.</creatorcontrib><creatorcontrib>Panarin, Е.F.</creatorcontrib><title>Study of N‐vinylpyrrolidone‐N‐vinylformamide copolymers labelled with indium‐113m</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Labelled Comp Radiopharm</addtitle><description>The procedure of the directed synthesis of N‐vinylpyrrolidone‐N‐vinylformamide (VP‐VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium‐113m were developed. The metal‐copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high‐performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium‐113m were optimized. It was shown that the VP‐VFA‐IDA copolymer firmly binds indium‐113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP‐VFA‐IDA‐In conjugates were found to be unstable in histidine challenge reaction.
The procedure of the directed synthesis of VP‐VFA copolymers with grafted IDA chelating units was developed. Labelling the copolymer with indium‐113m was studied. Resulting conjugates were found to be unstable in interligand exchange reaction with histidine.</description><subject>bioconjugates</subject><subject>Chelation</subject><subject>Chemical synthesis</subject><subject>Conjugates</subject><subject>Copolymers</subject><subject>Formamides - chemistry</subject><subject>Graft copolymers</subject><subject>High performance liquid chromatography</subject><subject>Histidine</subject><subject>Histidine - chemistry</subject><subject>Indium</subject><subject>Indium Radioisotopes - chemistry</subject><subject>indium‐113m</subject><subject>Labeling</subject><subject>labelling</subject><subject>Light scattering</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>N‐vinylpyrrolidone‐N‐vinylformamide copolymer</subject><subject>pH effects</subject><subject>Polymers - chemistry</subject><subject>Pyrrolidinones - chemistry</subject><subject>radiochemical synthesis</subject><subject>Radiochemistry</subject><subject>site specific radiopharmaceuticals</subject><subject>Vinylpyrrolidone</subject><subject>Viscometry</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10LtOwzAUBmALgWgpDLwAisQCQ4qd4zjOiCquqkDiMjBFieMIV04c7IYqG4_AM_IkuLR0QGKydM7nX0c_QocEjwnG0dlMCzuGGMMWGhKcpiEBSrfREAOLQsoxDNCeczOM_Y7SXTSIONCURWyIXh7nXdkHpgruvj4-31XT67a31mhVmkb60WZcGVvntSplIExrdF9L6wKdF1JrWQYLNX8NVFOqrvYfCIF6H-1UuXbyYP2O0PPlxdPkOpzeX91MzqehgBggrGIcMVmQhCeQCoCiEAUuJZF-QYVghFHM44gnDKqc5V6ISABJoJIx57KAETpZ5bbWvHXSzbNaOeGvyhtpOpcRzkmSkITEnh7_oTPT2cZf51WaMk4pRF6drpSwxjkrq6y1qs5tnxGcLfvOln1ny769PVondkUty438LdiDsxVYKC37_5Oy2-nk4SfyG99zjgc</recordid><startdate>20170530</startdate><enddate>20170530</enddate><creator>Gorshkov, N.I.</creator><creator>Miroslavov, А.Е.</creator><creator>Аlekseev, I.Е.</creator><creator>Lumpov, А.А.</creator><creator>Мurko, А.Y.</creator><creator>Gavrilova, I.I.</creator><creator>Saprykina, N.N.</creator><creator>Bezrukova, М.А.</creator><creator>Kipper, А.I.</creator><creator>Krasikov, V.D.</creator><creator>Suglobov, D.N.</creator><creator>Tyupina, M.Y.</creator><creator>Panarin, Е.F.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0150-3040</orcidid></search><sort><creationdate>20170530</creationdate><title>Study of N‐vinylpyrrolidone‐N‐vinylformamide copolymers labelled with indium‐113m</title><author>Gorshkov, N.I. ; Miroslavov, А.Е. ; Аlekseev, I.Е. ; Lumpov, А.А. ; Мurko, А.Y. ; Gavrilova, I.I. ; Saprykina, N.N. ; Bezrukova, М.А. ; Kipper, А.I. ; Krasikov, V.D. ; Suglobov, D.N. ; Tyupina, M.Y. ; Panarin, Е.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-f5026eb178739c33bbcb0de1ef504cc616408528763fa6ac33c2c3173fe588eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>bioconjugates</topic><topic>Chelation</topic><topic>Chemical synthesis</topic><topic>Conjugates</topic><topic>Copolymers</topic><topic>Formamides - chemistry</topic><topic>Graft copolymers</topic><topic>High performance liquid chromatography</topic><topic>Histidine</topic><topic>Histidine - chemistry</topic><topic>Indium</topic><topic>Indium Radioisotopes - chemistry</topic><topic>indium‐113m</topic><topic>Labeling</topic><topic>labelling</topic><topic>Light scattering</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>N‐vinylpyrrolidone‐N‐vinylformamide copolymer</topic><topic>pH effects</topic><topic>Polymers - chemistry</topic><topic>Pyrrolidinones - chemistry</topic><topic>radiochemical synthesis</topic><topic>Radiochemistry</topic><topic>site specific radiopharmaceuticals</topic><topic>Vinylpyrrolidone</topic><topic>Viscometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gorshkov, N.I.</creatorcontrib><creatorcontrib>Miroslavov, А.Е.</creatorcontrib><creatorcontrib>Аlekseev, I.Е.</creatorcontrib><creatorcontrib>Lumpov, А.А.</creatorcontrib><creatorcontrib>Мurko, А.Y.</creatorcontrib><creatorcontrib>Gavrilova, I.I.</creatorcontrib><creatorcontrib>Saprykina, N.N.</creatorcontrib><creatorcontrib>Bezrukova, М.А.</creatorcontrib><creatorcontrib>Kipper, А.I.</creatorcontrib><creatorcontrib>Krasikov, V.D.</creatorcontrib><creatorcontrib>Suglobov, D.N.</creatorcontrib><creatorcontrib>Tyupina, M.Y.</creatorcontrib><creatorcontrib>Panarin, Е.F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gorshkov, N.I.</au><au>Miroslavov, А.Е.</au><au>Аlekseev, I.Е.</au><au>Lumpov, А.А.</au><au>Мurko, А.Y.</au><au>Gavrilova, I.I.</au><au>Saprykina, N.N.</au><au>Bezrukova, М.А.</au><au>Kipper, А.I.</au><au>Krasikov, V.D.</au><au>Suglobov, D.N.</au><au>Tyupina, M.Y.</au><au>Panarin, Е.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of N‐vinylpyrrolidone‐N‐vinylformamide copolymers labelled with indium‐113m</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Labelled Comp Radiopharm</addtitle><date>2017-05-30</date><risdate>2017</risdate><volume>60</volume><issue>6</issue><spage>302</spage><epage>311</epage><pages>302-311</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>The procedure of the directed synthesis of N‐vinylpyrrolidone‐N‐vinylformamide (VP‐VFA) copolymers with grafted iminodiacetate (IDA) chelating units is presented. The methods for labelling resulting conjugates with indium‐113m were developed. The metal‐copolymer conjugates were characterized by different physicochemical methods, including IR and NMR, viscometry, light scattering, and exclusion high‐performance liquid chromatography. Parameters of radiochemical synthesis of the conjugates labelled with indium‐113m were optimized. It was shown that the VP‐VFA‐IDA copolymer firmly binds indium‐113m both in the acid and alkaline solutions, with pH of the reaction mixture having almost no effect on the complexation. VP‐VFA‐IDA‐In conjugates were found to be unstable in histidine challenge reaction.
The procedure of the directed synthesis of VP‐VFA copolymers with grafted IDA chelating units was developed. Labelling the copolymer with indium‐113m was studied. Resulting conjugates were found to be unstable in interligand exchange reaction with histidine.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28349626</pmid><doi>10.1002/jlcr.3503</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0150-3040</orcidid></addata></record> |
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| subjects | bioconjugates Chelation Chemical synthesis Conjugates Copolymers Formamides - chemistry Graft copolymers High performance liquid chromatography Histidine Histidine - chemistry Indium Indium Radioisotopes - chemistry indium‐113m Labeling labelling Light scattering NMR Nuclear magnetic resonance N‐vinylpyrrolidone‐N‐vinylformamide copolymer pH effects Polymers - chemistry Pyrrolidinones - chemistry radiochemical synthesis Radiochemistry site specific radiopharmaceuticals Vinylpyrrolidone Viscometry |
| title | Study of N‐vinylpyrrolidone‐N‐vinylformamide copolymers labelled with indium‐113m |
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