The Effect of Stereotactic Injections on Demyelination and Remyelination: a Study in the Cuprizone Model

Remyelination is the natural repair mechanism in demyelinating disorders of the central nervous system (CNS) such as multiple sclerosis. Several animal models have been used to study demyelination and remyelination. Among toxic animal models, oral administration of the toxin cuprizone leads to white...

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Veröffentlicht in:	Journal of molecular neuroscience 2017-04, Vol.61 (4), p.479-488
Hauptverfasser:	Tejedor, Laura Salinas, Wostradowski, Tanja, Gingele, Stefan, Skripuletz, Thomas, Gudi, Viktoria, Stangel, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Cell Biology Cerebral Cortex - drug effects Cerebral Cortex - pathology Corpus Callosum - drug effects Corpus Callosum - pathology Cuprizone - administration & dosage Cuprizone - pharmacokinetics Cuprizone - toxicity Demyelinating Diseases - etiology Demyelinating Diseases - pathology Disease Models, Animal Encephalomyelitis Gliosis - etiology Gray Matter - drug effects Gray Matter - pathology Injections, Intraventricular Lymphocytes Lymphocytes - drug effects Lymphocytes - pathology Male Mice Mice, Inbred C57BL Monoamine Oxidase Inhibitors - administration & dosage Monoamine Oxidase Inhibitors - pharmacokinetics Monoamine Oxidase Inhibitors - toxicity Multiple sclerosis Myelin Sheath - drug effects Myelin Sheath - pathology Nervous system Neurochemistry Neurology Neurosciences Proteomics Stereotaxic Techniques
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