Elevated levels of p-Mnk1, p-eIF4E and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas

Malignant astrocytomas are able to invade neighboring and distant areas of the normal brain. Signaling pathway alterations play important role in the development of astrocytomas. Deregulation of eukaryotic translation initiation factor 4E (eIF4E) by MAP kinase-interacting kinases (Mnk) on Ser-209 di...

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Veröffentlicht in:	Journal of neuro-oncology 2017-02, Vol.131 (3), p.485-493
Hauptverfasser:	Fan, Weibing, Wang, Weiyuan, Mao, Xinfa, Chu, Shuzhou, Feng, Juan, Xiao, Desheng, Zhou, Jianhua, Fan, Songqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Astrocytoma - diagnosis Astrocytoma - metabolism Biomarkers, Tumor - metabolism Brain Neoplasms - diagnosis Brain Neoplasms - metabolism Child DNA-Binding Proteins - metabolism Female Humans Intracellular Signaling Peptides and Proteins - metabolism Kaplan-Meier Estimate Laboratory Investigation Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - metabolism Neurology Oncology Phosphorylation Prognosis Protein-Serine-Threonine Kinases - metabolism Ribosomal Protein S6 Kinases, 70-kDa - metabolism Transcription Factors - metabolism Young Adult
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