Co‐administration of ginseng and ciprofloxacin ameliorates epididymo‐orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats
Summary Korean red ginseng (KRG) may be a beneficial adjuvant along with ciprofloxacin to ameliorate devastating effects of epididymo‐orchitis (EO) on male fertility. This study intends to assay the effects of KRG and ciprofloxacin on sperm quality and spermatogenic cells apoptosis in EO rats. We di...
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| Veröffentlicht in: | Andrologia 2017-04, Vol.49 (3), p.e12621-n/a |
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| creator | Eskandari, M. Ghalyanchi Langeroudi, A. Zeighami, H. Rostami, A. Kazemi, M. Eyni, H. Shokri, S. |
| description | Summary
Korean red ginseng (KRG) may be a beneficial adjuvant along with ciprofloxacin to ameliorate devastating effects of epididymo‐orchitis (EO) on male fertility. This study intends to assay the effects of KRG and ciprofloxacin on sperm quality and spermatogenic cells apoptosis in EO rats. We divided 54 adult rats into nine groups (n = 6 rats per group): control (CO), sham‐operated (SH), EO (E); ciprofloxacin (C), EO–ciprofloxacin (EC), KRG (G), EO–KRG (EG), ciprofloxacin–KRG (CG) and EO–ciprofloxacin–KRG (ECG). We administered ciprofloxacin and KRG 48 hr after the Escherichia coli (E. coli) injection for 10 days. Bilateral orchiectomy was performed after one sperm cycle (14 days) following the last treatment with ciprofloxacin and KRG. Total and progressive motility of E, C and EC groups decreased. However, motility is improved in CG and ECG in comparison with these groups. The E group induced negative changes in the architecture of testes tissue and dramatic increase in apoptosis indices. Interestingly, co‐administration of ciprofloxacin and KRG has dramatically improved Miller's and Johnsen's scores and decreased the apoptosis indices of animals in the ECG group. Combined treatment of ciprofloxacin and KRG may improve the quality of spermatozoa and attenuated apoptosis indices in the ECG group. |
| doi_str_mv | 10.1111/and.12621 |
| format | Article |
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Korean red ginseng (KRG) may be a beneficial adjuvant along with ciprofloxacin to ameliorate devastating effects of epididymo‐orchitis (EO) on male fertility. This study intends to assay the effects of KRG and ciprofloxacin on sperm quality and spermatogenic cells apoptosis in EO rats. We divided 54 adult rats into nine groups (n = 6 rats per group): control (CO), sham‐operated (SH), EO (E); ciprofloxacin (C), EO–ciprofloxacin (EC), KRG (G), EO–KRG (EG), ciprofloxacin–KRG (CG) and EO–ciprofloxacin–KRG (ECG). We administered ciprofloxacin and KRG 48 hr after the Escherichia coli (E. coli) injection for 10 days. Bilateral orchiectomy was performed after one sperm cycle (14 days) following the last treatment with ciprofloxacin and KRG. Total and progressive motility of E, C and EC groups decreased. However, motility is improved in CG and ECG in comparison with these groups. The E group induced negative changes in the architecture of testes tissue and dramatic increase in apoptosis indices. Interestingly, co‐administration of ciprofloxacin and KRG has dramatically improved Miller's and Johnsen's scores and decreased the apoptosis indices of animals in the ECG group. Combined treatment of ciprofloxacin and KRG may improve the quality of spermatozoa and attenuated apoptosis indices in the ECG group.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.12621</identifier><identifier>PMID: 27246506</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - therapeutic use ; apoptosis ; Apoptosis - drug effects ; ciprofloxacin ; Ciprofloxacin - adverse effects ; Ciprofloxacin - therapeutic use ; Disease Models, Animal ; Epididymitis - complications ; Epididymitis - drug therapy ; Epididymitis - microbiology ; epididymo‐orchitis ; Escherichia coli ; Escherichia coli - isolation & purification ; Escherichia coli Infections - complications ; Escherichia coli Infections - drug therapy ; Escherichia coli Infections - microbiology ; ginseng ; Humans ; Male ; Orchitis - complications ; Orchitis - drug therapy ; Orchitis - microbiology ; Panax - chemistry ; Plant Extracts - therapeutic use ; Rats ; Rats, Wistar ; Sperm Motility - drug effects ; Spermatozoa - drug effects</subject><ispartof>Andrologia, 2017-04, Vol.49 (3), p.e12621-n/a</ispartof><rights>2016 Blackwell Verlag GmbH</rights><rights>2016 Blackwell Verlag GmbH.</rights><rights>Copyright © 2017 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4211-ef2f7c3e20aed639389d46e714ef0f2fa2a6ada1cede3b0e06a7277574ecaf343</citedby><cites>FETCH-LOGICAL-c4211-ef2f7c3e20aed639389d46e714ef0f2fa2a6ada1cede3b0e06a7277574ecaf343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.12621$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.12621$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27246506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eskandari, M.</creatorcontrib><creatorcontrib>Ghalyanchi Langeroudi, A.</creatorcontrib><creatorcontrib>Zeighami, H.</creatorcontrib><creatorcontrib>Rostami, A.</creatorcontrib><creatorcontrib>Kazemi, M.</creatorcontrib><creatorcontrib>Eyni, H.</creatorcontrib><creatorcontrib>Shokri, S.</creatorcontrib><title>Co‐administration of ginseng and ciprofloxacin ameliorates epididymo‐orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Summary
Korean red ginseng (KRG) may be a beneficial adjuvant along with ciprofloxacin to ameliorate devastating effects of epididymo‐orchitis (EO) on male fertility. This study intends to assay the effects of KRG and ciprofloxacin on sperm quality and spermatogenic cells apoptosis in EO rats. We divided 54 adult rats into nine groups (n = 6 rats per group): control (CO), sham‐operated (SH), EO (E); ciprofloxacin (C), EO–ciprofloxacin (EC), KRG (G), EO–KRG (EG), ciprofloxacin–KRG (CG) and EO–ciprofloxacin–KRG (ECG). We administered ciprofloxacin and KRG 48 hr after the Escherichia coli (E. coli) injection for 10 days. Bilateral orchiectomy was performed after one sperm cycle (14 days) following the last treatment with ciprofloxacin and KRG. Total and progressive motility of E, C and EC groups decreased. However, motility is improved in CG and ECG in comparison with these groups. The E group induced negative changes in the architecture of testes tissue and dramatic increase in apoptosis indices. Interestingly, co‐administration of ciprofloxacin and KRG has dramatically improved Miller's and Johnsen's scores and decreased the apoptosis indices of animals in the ECG group. Combined treatment of ciprofloxacin and KRG may improve the quality of spermatozoa and attenuated apoptosis indices in the ECG group.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>ciprofloxacin</subject><subject>Ciprofloxacin - adverse effects</subject><subject>Ciprofloxacin - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Epididymitis - complications</subject><subject>Epididymitis - drug therapy</subject><subject>Epididymitis - microbiology</subject><subject>epididymo‐orchitis</subject><subject>Escherichia coli</subject><subject>Escherichia coli - isolation & purification</subject><subject>Escherichia coli Infections - complications</subject><subject>Escherichia coli Infections - drug therapy</subject><subject>Escherichia coli Infections - microbiology</subject><subject>ginseng</subject><subject>Humans</subject><subject>Male</subject><subject>Orchitis - complications</subject><subject>Orchitis - drug therapy</subject><subject>Orchitis - microbiology</subject><subject>Panax - chemistry</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sperm Motility - drug effects</subject><subject>Spermatozoa - drug effects</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQhy0EoqvSAy-ALHGBQ1rbcezkWC1_pQoucI6m9nhx5dhpnKjsjUfgYXgingTvpnBAQmIulsafPv1mhpCnnJ3zUhcQ7TkXSvAHZMNl3VVMaPGQbFjN6ko2qjshZznfsFKy0VrKx-SkEFI1TG3Ij236-e072MFHn-cJZp8iTY7ufMwYd7TYqfHjlFxIX8H4SGHA4FMhMVMcvfV2PxwcaTJf_Owz9dEuBi2FMOMqPPRoHnEa6O0Cwc_7o_fYgTntMHpDDYaQKYxpnFMuGpdCSHe-ZPDRoTkGK5pizE_IIwch49n9e0o-v3n9afuuuvr49v328qoyUnBeoRNOmxoFA7Sq7uq2s1Kh5hIdK38gQIEFXsJifc2QKdBC60ZLNOBqWZ-SF6u3zH-7YJ77wedDToiYltzztuVatVzy_0CFUh0Tsino87_Qm7RMsQxSKK26lumOFerlSpkp5Tyh68fJDzDte876w-H7ssL-ePjCPrs3LtcD2j_k7zMX4GIF7nzA_b9N_eWHV6vyF9IQvmQ</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Eskandari, M.</creator><creator>Ghalyanchi Langeroudi, A.</creator><creator>Zeighami, H.</creator><creator>Rostami, A.</creator><creator>Kazemi, M.</creator><creator>Eyni, H.</creator><creator>Shokri, S.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Co‐administration of ginseng and ciprofloxacin ameliorates epididymo‐orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats</title><author>Eskandari, M. ; Ghalyanchi Langeroudi, A. ; Zeighami, H. ; Rostami, A. ; Kazemi, M. ; Eyni, H. ; Shokri, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4211-ef2f7c3e20aed639389d46e714ef0f2fa2a6ada1cede3b0e06a7277574ecaf343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>ciprofloxacin</topic><topic>Ciprofloxacin - adverse effects</topic><topic>Ciprofloxacin - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Epididymitis - complications</topic><topic>Epididymitis - drug therapy</topic><topic>Epididymitis - microbiology</topic><topic>epididymo‐orchitis</topic><topic>Escherichia coli</topic><topic>Escherichia coli - isolation & purification</topic><topic>Escherichia coli Infections - complications</topic><topic>Escherichia coli Infections - drug therapy</topic><topic>Escherichia coli Infections - microbiology</topic><topic>ginseng</topic><topic>Humans</topic><topic>Male</topic><topic>Orchitis - complications</topic><topic>Orchitis - drug therapy</topic><topic>Orchitis - microbiology</topic><topic>Panax - chemistry</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sperm Motility - drug effects</topic><topic>Spermatozoa - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eskandari, M.</creatorcontrib><creatorcontrib>Ghalyanchi Langeroudi, A.</creatorcontrib><creatorcontrib>Zeighami, H.</creatorcontrib><creatorcontrib>Rostami, A.</creatorcontrib><creatorcontrib>Kazemi, M.</creatorcontrib><creatorcontrib>Eyni, H.</creatorcontrib><creatorcontrib>Shokri, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eskandari, M.</au><au>Ghalyanchi Langeroudi, A.</au><au>Zeighami, H.</au><au>Rostami, A.</au><au>Kazemi, M.</au><au>Eyni, H.</au><au>Shokri, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co‐administration of ginseng and ciprofloxacin ameliorates epididymo‐orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2017-04</date><risdate>2017</risdate><volume>49</volume><issue>3</issue><spage>e12621</spage><epage>n/a</epage><pages>e12621-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Summary
Korean red ginseng (KRG) may be a beneficial adjuvant along with ciprofloxacin to ameliorate devastating effects of epididymo‐orchitis (EO) on male fertility. This study intends to assay the effects of KRG and ciprofloxacin on sperm quality and spermatogenic cells apoptosis in EO rats. We divided 54 adult rats into nine groups (n = 6 rats per group): control (CO), sham‐operated (SH), EO (E); ciprofloxacin (C), EO–ciprofloxacin (EC), KRG (G), EO–KRG (EG), ciprofloxacin–KRG (CG) and EO–ciprofloxacin–KRG (ECG). We administered ciprofloxacin and KRG 48 hr after the Escherichia coli (E. coli) injection for 10 days. Bilateral orchiectomy was performed after one sperm cycle (14 days) following the last treatment with ciprofloxacin and KRG. Total and progressive motility of E, C and EC groups decreased. However, motility is improved in CG and ECG in comparison with these groups. The E group induced negative changes in the architecture of testes tissue and dramatic increase in apoptosis indices. Interestingly, co‐administration of ciprofloxacin and KRG has dramatically improved Miller's and Johnsen's scores and decreased the apoptosis indices of animals in the ECG group. Combined treatment of ciprofloxacin and KRG may improve the quality of spermatozoa and attenuated apoptosis indices in the ECG group.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27246506</pmid><doi>10.1111/and.12621</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use apoptosis Apoptosis - drug effects ciprofloxacin Ciprofloxacin - adverse effects Ciprofloxacin - therapeutic use Disease Models, Animal Epididymitis - complications Epididymitis - drug therapy Epididymitis - microbiology epididymo‐orchitis Escherichia coli Escherichia coli - isolation & purification Escherichia coli Infections - complications Escherichia coli Infections - drug therapy Escherichia coli Infections - microbiology ginseng Humans Male Orchitis - complications Orchitis - drug therapy Orchitis - microbiology Panax - chemistry Plant Extracts - therapeutic use Rats Rats, Wistar Sperm Motility - drug effects Spermatozoa - drug effects |
| title | Co‐administration of ginseng and ciprofloxacin ameliorates epididymo‐orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats |
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