Central nervous system infections caused by varicella-zoster virus
We carried out a clinical and epidemiological study of adult patients with varicella-zoster virus central nervous system infection diagnosed by PCR in cerebrospinal fluid. Twenty-six patients were included. Twelve (46.2 %) patients were diagnosed with meningitis and fourteen (53.8 %) with meningoenc...
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| Veröffentlicht in: | Journal of neurovirology 2016-08, Vol.22 (4), p.529-532 |
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| creator | Chamizo, Francisco J. Gilarranz, Raúl Hernández, Melisa Ramos, Diana Pena, María José |
| description | We carried out a clinical and epidemiological study of adult patients with varicella-zoster virus central nervous system infection diagnosed by PCR in cerebrospinal fluid. Twenty-six patients were included. Twelve (46.2 %) patients were diagnosed with meningitis and fourteen (53.8 %) with meningoencephalitis. Twelve (46.2 %) had cranial nerves involvement (mainly the facial (VII) and vestibulocochlear (VIII) nerves), six (23.1 %) had cerebellar involvement, fourteen (53.8 %) had rash, and four (15.4 %) developed Ramsay Hunt syndrome. Three (11.5 %) patients had sequelae. Length of stay was significantly lower in patients diagnosed with meningitis and treatment with acyclovir was more frequent in patients diagnosed with meningoencephalitis. We believe routine detection of varicella-zoster virus, regardless of the presence of rash, is important because the patient may benefit from a different clinical management. |
| doi_str_mv | 10.1007/s13365-016-0422-y |
| format | Article |
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Twenty-six patients were included. Twelve (46.2 %) patients were diagnosed with meningitis and fourteen (53.8 %) with meningoencephalitis. Twelve (46.2 %) had cranial nerves involvement (mainly the facial (VII) and vestibulocochlear (VIII) nerves), six (23.1 %) had cerebellar involvement, fourteen (53.8 %) had rash, and four (15.4 %) developed Ramsay Hunt syndrome. Three (11.5 %) patients had sequelae. Length of stay was significantly lower in patients diagnosed with meningitis and treatment with acyclovir was more frequent in patients diagnosed with meningoencephalitis. We believe routine detection of varicella-zoster virus, regardless of the presence of rash, is important because the patient may benefit from a different clinical management.</description><identifier>ISSN: 1355-0284</identifier><identifier>EISSN: 1538-2443</identifier><identifier>DOI: 10.1007/s13365-016-0422-y</identifier><identifier>PMID: 26769041</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acyclovir - therapeutic use ; Adult ; Aged ; Aged, 80 and over ; Antiviral Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Central Nervous System - pathology ; Central Nervous System - virology ; Cerebellum - pathology ; Cerebellum - virology ; Cranial Nerves - pathology ; Cranial Nerves - virology ; Encephalitis, Varicella Zoster - cerebrospinal fluid ; Encephalitis, Varicella Zoster - diagnosis ; Encephalitis, Varicella Zoster - drug therapy ; Encephalitis, Varicella Zoster - virology ; Female ; Herpes Zoster Oticus - cerebrospinal fluid ; Herpes Zoster Oticus - diagnosis ; Herpes Zoster Oticus - drug therapy ; Herpes Zoster Oticus - virology ; Herpesviridae ; Herpesvirus 3, Human - drug effects ; Herpesvirus 3, Human - pathogenicity ; Herpesvirus 3, Human - physiology ; Humans ; Immunology ; Infectious Diseases ; Male ; Meningitis, Viral - cerebrospinal fluid ; Meningitis, Viral - diagnosis ; Meningitis, Viral - drug therapy ; Meningitis, Viral - virology ; Middle Aged ; Neurology ; Neurosciences ; Retrospective Studies ; Short Communication ; Vestibulocochlear Nerve - pathology ; Vestibulocochlear Nerve - virology ; Virology</subject><ispartof>Journal of neurovirology, 2016-08, Vol.22 (4), p.529-532</ispartof><rights>Journal of NeuroVirology, Inc. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-ddbd1f2360c2d4a3c091d57c972d7bf287197516e7bc7f993f203103464405533</citedby><cites>FETCH-LOGICAL-c377t-ddbd1f2360c2d4a3c091d57c972d7bf287197516e7bc7f993f203103464405533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13365-016-0422-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13365-016-0422-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26769041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chamizo, Francisco J.</creatorcontrib><creatorcontrib>Gilarranz, Raúl</creatorcontrib><creatorcontrib>Hernández, Melisa</creatorcontrib><creatorcontrib>Ramos, Diana</creatorcontrib><creatorcontrib>Pena, María José</creatorcontrib><title>Central nervous system infections caused by varicella-zoster virus</title><title>Journal of neurovirology</title><addtitle>J. Neurovirol</addtitle><addtitle>J Neurovirol</addtitle><description>We carried out a clinical and epidemiological study of adult patients with varicella-zoster virus central nervous system infection diagnosed by PCR in cerebrospinal fluid. Twenty-six patients were included. Twelve (46.2 %) patients were diagnosed with meningitis and fourteen (53.8 %) with meningoencephalitis. Twelve (46.2 %) had cranial nerves involvement (mainly the facial (VII) and vestibulocochlear (VIII) nerves), six (23.1 %) had cerebellar involvement, fourteen (53.8 %) had rash, and four (15.4 %) developed Ramsay Hunt syndrome. Three (11.5 %) patients had sequelae. Length of stay was significantly lower in patients diagnosed with meningitis and treatment with acyclovir was more frequent in patients diagnosed with meningoencephalitis. We believe routine detection of varicella-zoster virus, regardless of the presence of rash, is important because the patient may benefit from a different clinical management.</description><subject>Acyclovir - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Central Nervous System - pathology</subject><subject>Central Nervous System - virology</subject><subject>Cerebellum - pathology</subject><subject>Cerebellum - virology</subject><subject>Cranial Nerves - pathology</subject><subject>Cranial Nerves - virology</subject><subject>Encephalitis, Varicella Zoster - cerebrospinal fluid</subject><subject>Encephalitis, Varicella Zoster - diagnosis</subject><subject>Encephalitis, Varicella Zoster - drug therapy</subject><subject>Encephalitis, Varicella Zoster - virology</subject><subject>Female</subject><subject>Herpes Zoster Oticus - cerebrospinal fluid</subject><subject>Herpes Zoster Oticus - diagnosis</subject><subject>Herpes Zoster Oticus - drug therapy</subject><subject>Herpes Zoster Oticus - virology</subject><subject>Herpesviridae</subject><subject>Herpesvirus 3, Human - drug effects</subject><subject>Herpesvirus 3, Human - pathogenicity</subject><subject>Herpesvirus 3, Human - physiology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Male</subject><subject>Meningitis, Viral - cerebrospinal fluid</subject><subject>Meningitis, Viral - diagnosis</subject><subject>Meningitis, Viral - drug therapy</subject><subject>Meningitis, Viral - virology</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Retrospective Studies</subject><subject>Short Communication</subject><subject>Vestibulocochlear Nerve - pathology</subject><subject>Vestibulocochlear Nerve - virology</subject><subject>Virology</subject><issn>1355-0284</issn><issn>1538-2443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LxDAQhoMorq7-AC_So5doJt896uIXLHjRc2iTVLr0Y03ahfrrzbqrRxEGZmCeeRkehC6AXAMh6iYCY1JgAhITTimeDtAJCKYx5ZwdppmJtKWaz9BpjCtCgEmqj9GMSiVzwuEE3S18N4SiyTofNv0YszjFwbdZ3VXeDnXfxcwWY_QuK6dsU4Ta-qYp8GefqJBt6jDGM3RUFU305_s-R28P96-LJ7x8eXxe3C6xZUoN2LnSQUWZJJY6XjBLcnBC2VxRp8qKagW5EiC9Kq2q8pxVlDAgjEvOiRCMzdHVLncd-o_Rx8G0dfx-p_PpcwNag5JCg_4HmvSlYpBQ2KE29DEGX5l1qNsiTAaI2Vo2O8smWTZby2ZKN5f7-LFsvfu9-NGaALoDYlp17z6YVT-GLtn5I_ULjIqHAQ</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Chamizo, Francisco J.</creator><creator>Gilarranz, Raúl</creator><creator>Hernández, Melisa</creator><creator>Ramos, Diana</creator><creator>Pena, María José</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20160801</creationdate><title>Central nervous system infections caused by varicella-zoster virus</title><author>Chamizo, Francisco J. ; Gilarranz, Raúl ; Hernández, Melisa ; Ramos, Diana ; Pena, María José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-ddbd1f2360c2d4a3c091d57c972d7bf287197516e7bc7f993f203103464405533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acyclovir - therapeutic use</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Central Nervous System - pathology</topic><topic>Central Nervous System - virology</topic><topic>Cerebellum - pathology</topic><topic>Cerebellum - virology</topic><topic>Cranial Nerves - pathology</topic><topic>Cranial Nerves - virology</topic><topic>Encephalitis, Varicella Zoster - cerebrospinal fluid</topic><topic>Encephalitis, Varicella Zoster - diagnosis</topic><topic>Encephalitis, Varicella Zoster - drug therapy</topic><topic>Encephalitis, Varicella Zoster - virology</topic><topic>Female</topic><topic>Herpes Zoster Oticus - cerebrospinal fluid</topic><topic>Herpes Zoster Oticus - diagnosis</topic><topic>Herpes Zoster Oticus - drug therapy</topic><topic>Herpes Zoster Oticus - virology</topic><topic>Herpesviridae</topic><topic>Herpesvirus 3, Human - drug effects</topic><topic>Herpesvirus 3, Human - pathogenicity</topic><topic>Herpesvirus 3, Human - physiology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Male</topic><topic>Meningitis, Viral - cerebrospinal fluid</topic><topic>Meningitis, Viral - diagnosis</topic><topic>Meningitis, Viral - drug therapy</topic><topic>Meningitis, Viral - virology</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Retrospective Studies</topic><topic>Short Communication</topic><topic>Vestibulocochlear Nerve - pathology</topic><topic>Vestibulocochlear Nerve - virology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chamizo, Francisco J.</creatorcontrib><creatorcontrib>Gilarranz, Raúl</creatorcontrib><creatorcontrib>Hernández, Melisa</creatorcontrib><creatorcontrib>Ramos, Diana</creatorcontrib><creatorcontrib>Pena, María José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of neurovirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chamizo, Francisco J.</au><au>Gilarranz, Raúl</au><au>Hernández, Melisa</au><au>Ramos, Diana</au><au>Pena, María José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central nervous system infections caused by varicella-zoster virus</atitle><jtitle>Journal of neurovirology</jtitle><stitle>J. 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| subjects | Acyclovir - therapeutic use Adult Aged Aged, 80 and over Antiviral Agents - therapeutic use Biomedical and Life Sciences Biomedicine Central Nervous System - pathology Central Nervous System - virology Cerebellum - pathology Cerebellum - virology Cranial Nerves - pathology Cranial Nerves - virology Encephalitis, Varicella Zoster - cerebrospinal fluid Encephalitis, Varicella Zoster - diagnosis Encephalitis, Varicella Zoster - drug therapy Encephalitis, Varicella Zoster - virology Female Herpes Zoster Oticus - cerebrospinal fluid Herpes Zoster Oticus - diagnosis Herpes Zoster Oticus - drug therapy Herpes Zoster Oticus - virology Herpesviridae Herpesvirus 3, Human - drug effects Herpesvirus 3, Human - pathogenicity Herpesvirus 3, Human - physiology Humans Immunology Infectious Diseases Male Meningitis, Viral - cerebrospinal fluid Meningitis, Viral - diagnosis Meningitis, Viral - drug therapy Meningitis, Viral - virology Middle Aged Neurology Neurosciences Retrospective Studies Short Communication Vestibulocochlear Nerve - pathology Vestibulocochlear Nerve - virology Virology |
| title | Central nervous system infections caused by varicella-zoster virus |
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