Long‐term exercise training prevents mammary tumorigenesis‐induced muscle wasting in rats through the regulation of TWEAK signalling

Aim Exercise training has been suggested as a non‐pharmacological approach to prevent skeletal muscle wasting and improve muscle function in cancer cachexia. However, little is known about the molecular mechanisms underlying such beneficial effect. In this study, we aimed to, firstly, examine the co...

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Veröffentlicht in:	Acta Physiologica 2017-04, Vol.219 (4), p.803-813
Hauptverfasser:	Padrão, A. I., Figueira, A. C. C., Faustino‐Rocha, A. I., Gama, A., Loureiro, M. M., Neuparth, M. J., Moreira‐Gonçalves, D., Vitorino, R., Amado, F., Santos, L. L., Oliveira, P. A., Duarte, J. A., Ferreira, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins - biosynthesis Cachexia - etiology Cachexia - metabolism Cytokine TWEAK Disease Models, Animal Female gastrocnemius inflammation mammary carcinogenesis Mammary Neoplasms, Experimental - complications Membrane Proteins - biosynthesis Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Atrophy - etiology Muscular Atrophy - metabolism NF-kappa B - metabolism NF‐κB signalling oxidative metabolism Physical Conditioning, Animal - methods Random Allocation Rats Rats, Sprague-Dawley Signal Transduction - physiology Tumor Necrosis Factors - biosynthesis
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