Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus
Aims To evaluate microfibrillar-associated protein 4 (MFAP4) as a marker of micro- and macrovascular complications in patients with type 1 diabetes. Methods This cross-sectional study included 203 persons with a long duration of type 1 diabetes from a population-based cohort ascertained in the forme...
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| Veröffentlicht in: | Acta diabetologica 2017-04, Vol.54 (4), p.367-372 |
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| creator | Blindbæk, S.L. Schlosser, A. Green, A. Holmskov, U. Sorensen, G.L. Grauslund, J. |
| description | Aims
To evaluate microfibrillar-associated protein 4 (MFAP4) as a marker of micro- and macrovascular complications in patients with type 1 diabetes.
Methods
This cross-sectional study included 203 persons with a long duration of type 1 diabetes from a population-based cohort ascertained in the former Funen County, Denmark. Detection of plasma-MFAP4 (pMFAP4) was performed by the AlphaLISA Technique. Diabetic retinopathy (DR) was graded in accordance with the Early Treatment Diabetic Retinopathy Study adaptation of the modified Airlie House classification. A monofilament test was used to test for neuropathy, and nephropathy was evaluated in a single spot urine sample. Data describing macrovascular disease were obtained from the Danish National Patient Register.
Results
Median age and duration of diabetes were 58.7 and 43 years, respectively, and 61% were males. High levels of pMFAP4 were found in participants of old age, in women and in non-smokers (
p
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| doi_str_mv | 10.1007/s00592-016-0953-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1881762689</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1881762689</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-82289ba989a397768f2acc8e052314e1c9ca066bc18b07a1d00a95e407d9c85a3</originalsourceid><addsrcrecordid>eNqNkU9rFTEUxUOp2Gf1A3RTAt20i-jNn5kky0exVajool2HTOa-kjJ_nslM5X0LP7Jp5ylFEFzlQn7n3JwcQk44vOcA-kMGqKxgwGsGtpJsd0BWXEnBKiHlIVmBVcAqJewReZPzAwAXWprX5EgYkLYyakV-rnMeQ_RTHAfa4PQDcaB9DGncxCbFrvOJ-T2CLd2mccI4UEXPv1ytv6kL6od24dky-jI--hzmoqRh7LddDM_umRZdNw73bMLU02m3RcppG33Zipn22HVxmvNb8mrju4zv9ucxubv6eHv5id18vf58ub5hQWk-MSOEsY23xnppta7NRvgQDEKJzhXyYIOHum4CNw1oz1sAbytUoFsbTOXlMTlffEuk7zPmyfUxh_IIP-A4Z8eN4boWtbH_gVaq5pKbuqBnf6EP45yGEqRQWmuhxTPFF6r8Vc4JN26bYu_TznFwT826pVlXmnVPzbpd0Zzuneemx_aP4neVBRALkMvVcI_pxep_uv4CEgevMQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1877727286</pqid></control><display><type>article</type><title>Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Blindbæk, S.L. ; Schlosser, A. ; Green, A. ; Holmskov, U. ; Sorensen, G.L. ; Grauslund, J.</creator><creatorcontrib>Blindbæk, S.L. ; Schlosser, A. ; Green, A. ; Holmskov, U. ; Sorensen, G.L. ; Grauslund, J.</creatorcontrib><description>Aims
To evaluate microfibrillar-associated protein 4 (MFAP4) as a marker of micro- and macrovascular complications in patients with type 1 diabetes.
Methods
This cross-sectional study included 203 persons with a long duration of type 1 diabetes from a population-based cohort ascertained in the former Funen County, Denmark. Detection of plasma-MFAP4 (pMFAP4) was performed by the AlphaLISA Technique. Diabetic retinopathy (DR) was graded in accordance with the Early Treatment Diabetic Retinopathy Study adaptation of the modified Airlie House classification. A monofilament test was used to test for neuropathy, and nephropathy was evaluated in a single spot urine sample. Data describing macrovascular disease were obtained from the Danish National Patient Register.
Results
Median age and duration of diabetes were 58.7 and 43 years, respectively, and 61% were males. High levels of pMFAP4 were found in participants of old age, in women and in non-smokers (
p
< 0.05). In a multiple logistic regression model, patients with high levels of pMFAP4 were more likely to have diabetic neuropathy (OR 2.47 for quartile 4 versus quartile 1, 95% CI 1.01–6.03). No association was found between pMFAP4 and proliferative diabetic retinopathy, nephropathy or macrovascular disease.
Conclusions
No association between pMFAP4 and macrovascular vascular complications was found. However, high levels of pMFAP4 correlated independently with diabetic neuropathy. Further studies on the predictive value of increased circulating MFAP4 in diabetic neuropathy are warranted.</description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-016-0953-y</identifier><identifier>PMID: 28039584</identifier><identifier>CODEN: ACDAEZ</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers - blood ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - diagnosis ; Carrier Proteins - blood ; Circulatory system ; Cross-Sectional Studies ; Denmark ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - diagnosis ; Diabetic Angiopathies - blood ; Diabetic Angiopathies - diagnosis ; Diabetic Neuropathies - blood ; Diabetic Neuropathies - complications ; Diabetic Neuropathies - diagnosis ; Diabetic neuropathy ; Diabetic retinopathy ; Diabetic Retinopathy - blood ; Diabetic Retinopathy - complications ; Diabetic Retinopathy - diagnosis ; Extracellular Matrix Proteins - blood ; Female ; Glycoproteins - blood ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Original Article ; Physiology ; Predictive Value of Tests ; Proteins ; Risk Factors</subject><ispartof>Acta diabetologica, 2017-04, Vol.54 (4), p.367-372</ispartof><rights>Springer-Verlag Italia 2016</rights><rights>Acta Diabetologica is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-82289ba989a397768f2acc8e052314e1c9ca066bc18b07a1d00a95e407d9c85a3</citedby><cites>FETCH-LOGICAL-c471t-82289ba989a397768f2acc8e052314e1c9ca066bc18b07a1d00a95e407d9c85a3</cites><orcidid>0000-0003-0628-684X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00592-016-0953-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00592-016-0953-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28039584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blindbæk, S.L.</creatorcontrib><creatorcontrib>Schlosser, A.</creatorcontrib><creatorcontrib>Green, A.</creatorcontrib><creatorcontrib>Holmskov, U.</creatorcontrib><creatorcontrib>Sorensen, G.L.</creatorcontrib><creatorcontrib>Grauslund, J.</creatorcontrib><title>Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description>Aims
To evaluate microfibrillar-associated protein 4 (MFAP4) as a marker of micro- and macrovascular complications in patients with type 1 diabetes.
Methods
This cross-sectional study included 203 persons with a long duration of type 1 diabetes from a population-based cohort ascertained in the former Funen County, Denmark. Detection of plasma-MFAP4 (pMFAP4) was performed by the AlphaLISA Technique. Diabetic retinopathy (DR) was graded in accordance with the Early Treatment Diabetic Retinopathy Study adaptation of the modified Airlie House classification. A monofilament test was used to test for neuropathy, and nephropathy was evaluated in a single spot urine sample. Data describing macrovascular disease were obtained from the Danish National Patient Register.
Results
Median age and duration of diabetes were 58.7 and 43 years, respectively, and 61% were males. High levels of pMFAP4 were found in participants of old age, in women and in non-smokers (
p
< 0.05). In a multiple logistic regression model, patients with high levels of pMFAP4 were more likely to have diabetic neuropathy (OR 2.47 for quartile 4 versus quartile 1, 95% CI 1.01–6.03). No association was found between pMFAP4 and proliferative diabetic retinopathy, nephropathy or macrovascular disease.
Conclusions
No association between pMFAP4 and macrovascular vascular complications was found. However, high levels of pMFAP4 correlated independently with diabetic neuropathy. Further studies on the predictive value of increased circulating MFAP4 in diabetic neuropathy are warranted.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Carrier Proteins - blood</subject><subject>Circulatory system</subject><subject>Cross-Sectional Studies</subject><subject>Denmark</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Diabetic Angiopathies - blood</subject><subject>Diabetic Angiopathies - diagnosis</subject><subject>Diabetic Neuropathies - blood</subject><subject>Diabetic Neuropathies - complications</subject><subject>Diabetic Neuropathies - diagnosis</subject><subject>Diabetic neuropathy</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - blood</subject><subject>Diabetic Retinopathy - complications</subject><subject>Diabetic Retinopathy - diagnosis</subject><subject>Extracellular Matrix Proteins - blood</subject><subject>Female</subject><subject>Glycoproteins - blood</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Physiology</subject><subject>Predictive Value of Tests</subject><subject>Proteins</subject><subject>Risk Factors</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU9rFTEUxUOp2Gf1A3RTAt20i-jNn5kky0exVajool2HTOa-kjJ_nslM5X0LP7Jp5ylFEFzlQn7n3JwcQk44vOcA-kMGqKxgwGsGtpJsd0BWXEnBKiHlIVmBVcAqJewReZPzAwAXWprX5EgYkLYyakV-rnMeQ_RTHAfa4PQDcaB9DGncxCbFrvOJ-T2CLd2mccI4UEXPv1ytv6kL6od24dky-jI--hzmoqRh7LddDM_umRZdNw73bMLU02m3RcppG33Zipn22HVxmvNb8mrju4zv9ucxubv6eHv5id18vf58ub5hQWk-MSOEsY23xnppta7NRvgQDEKJzhXyYIOHum4CNw1oz1sAbytUoFsbTOXlMTlffEuk7zPmyfUxh_IIP-A4Z8eN4boWtbH_gVaq5pKbuqBnf6EP45yGEqRQWmuhxTPFF6r8Vc4JN26bYu_TznFwT826pVlXmnVPzbpd0Zzuneemx_aP4neVBRALkMvVcI_pxep_uv4CEgevMQ</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Blindbæk, S.L.</creator><creator>Schlosser, A.</creator><creator>Green, A.</creator><creator>Holmskov, U.</creator><creator>Sorensen, G.L.</creator><creator>Grauslund, J.</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0628-684X</orcidid></search><sort><creationdate>20170401</creationdate><title>Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus</title><author>Blindbæk, S.L. ; Schlosser, A. ; Green, A. ; Holmskov, U. ; Sorensen, G.L. ; Grauslund, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-82289ba989a397768f2acc8e052314e1c9ca066bc18b07a1d00a95e407d9c85a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Carrier Proteins - blood</topic><topic>Circulatory system</topic><topic>Cross-Sectional Studies</topic><topic>Denmark</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - diagnosis</topic><topic>Diabetic Angiopathies - blood</topic><topic>Diabetic Angiopathies - diagnosis</topic><topic>Diabetic Neuropathies - blood</topic><topic>Diabetic Neuropathies - complications</topic><topic>Diabetic Neuropathies - diagnosis</topic><topic>Diabetic neuropathy</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - blood</topic><topic>Diabetic Retinopathy - complications</topic><topic>Diabetic Retinopathy - diagnosis</topic><topic>Extracellular Matrix Proteins - blood</topic><topic>Female</topic><topic>Glycoproteins - blood</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Physiology</topic><topic>Predictive Value of Tests</topic><topic>Proteins</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blindbæk, S.L.</creatorcontrib><creatorcontrib>Schlosser, A.</creatorcontrib><creatorcontrib>Green, A.</creatorcontrib><creatorcontrib>Holmskov, U.</creatorcontrib><creatorcontrib>Sorensen, G.L.</creatorcontrib><creatorcontrib>Grauslund, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Acta diabetologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blindbæk, S.L.</au><au>Schlosser, A.</au><au>Green, A.</au><au>Holmskov, U.</au><au>Sorensen, G.L.</au><au>Grauslund, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus</atitle><jtitle>Acta diabetologica</jtitle><stitle>Acta Diabetol</stitle><addtitle>Acta Diabetol</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>54</volume><issue>4</issue><spage>367</spage><epage>372</epage><pages>367-372</pages><issn>0940-5429</issn><eissn>1432-5233</eissn><coden>ACDAEZ</coden><abstract>Aims
To evaluate microfibrillar-associated protein 4 (MFAP4) as a marker of micro- and macrovascular complications in patients with type 1 diabetes.
Methods
This cross-sectional study included 203 persons with a long duration of type 1 diabetes from a population-based cohort ascertained in the former Funen County, Denmark. Detection of plasma-MFAP4 (pMFAP4) was performed by the AlphaLISA Technique. Diabetic retinopathy (DR) was graded in accordance with the Early Treatment Diabetic Retinopathy Study adaptation of the modified Airlie House classification. A monofilament test was used to test for neuropathy, and nephropathy was evaluated in a single spot urine sample. Data describing macrovascular disease were obtained from the Danish National Patient Register.
Results
Median age and duration of diabetes were 58.7 and 43 years, respectively, and 61% were males. High levels of pMFAP4 were found in participants of old age, in women and in non-smokers (
p
< 0.05). In a multiple logistic regression model, patients with high levels of pMFAP4 were more likely to have diabetic neuropathy (OR 2.47 for quartile 4 versus quartile 1, 95% CI 1.01–6.03). No association was found between pMFAP4 and proliferative diabetic retinopathy, nephropathy or macrovascular disease.
Conclusions
No association between pMFAP4 and macrovascular vascular complications was found. However, high levels of pMFAP4 correlated independently with diabetic neuropathy. Further studies on the predictive value of increased circulating MFAP4 in diabetic neuropathy are warranted.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>28039584</pmid><doi>10.1007/s00592-016-0953-y</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0628-684X</orcidid></addata></record> |
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| ispartof | Acta diabetologica, 2017-04, Vol.54 (4), p.367-372 |
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| subjects | Adult Aged Aged, 80 and over Biomarkers - blood Cardiovascular Diseases - blood Cardiovascular Diseases - complications Cardiovascular Diseases - diagnosis Carrier Proteins - blood Circulatory system Cross-Sectional Studies Denmark Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diabetic Angiopathies - blood Diabetic Angiopathies - diagnosis Diabetic Neuropathies - blood Diabetic Neuropathies - complications Diabetic Neuropathies - diagnosis Diabetic neuropathy Diabetic retinopathy Diabetic Retinopathy - blood Diabetic Retinopathy - complications Diabetic Retinopathy - diagnosis Extracellular Matrix Proteins - blood Female Glycoproteins - blood Humans Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Article Physiology Predictive Value of Tests Proteins Risk Factors |
| title | Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus |
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