Wound‐healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model
Centella asiatica (CA) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing. This study demonstrated that CA extract facilitates the wound‐repair process by promoting fibroblast proliferation and collagen synthesis and exhibits antibacterial activity...
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| Veröffentlicht in: | Journal of tissue engineering and regenerative medicine 2017-03, Vol.11 (3), p.905-915 |
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| container_title | Journal of tissue engineering and regenerative medicine |
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| creator | Yao, Chun‐Hsu Yeh, Jen‐Yu Chen, Yueh‐Sheng Li, Ming‐Hsien Huang, Chiung‐Hua |
| description | Centella asiatica (CA) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing. This study demonstrated that CA extract facilitates the wound‐repair process by promoting fibroblast proliferation and collagen synthesis and exhibits antibacterial activity. Gelatin nanofibres containing C. asiatica extract were fabricated via electrospinning and were shown to exhibit dermal wound‐healing activity in a rat model. The wound areas of rat skin treated with electrospun gelatin membranes containing C. asiatica (EGC) presented the highest recovery rate compared with those treated with gauze, neat gelatin membranes and commercial wound dressings. The results of the histopathological examination support the outcome of the wound models. Contact‐angle and water‐retention measurements confirmed that the addition of C. asiatica extract did not significantly affect the hydrophilicity of the EGC membranes. The measured weight loss revealed that the EGC membranes are biodegradable. The findings suggest that EGC membranes are a promising material for the treatment of skin wounds. Copyright © 2015 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/term.1992 |
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This study demonstrated that CA extract facilitates the wound‐repair process by promoting fibroblast proliferation and collagen synthesis and exhibits antibacterial activity. Gelatin nanofibres containing C. asiatica extract were fabricated via electrospinning and were shown to exhibit dermal wound‐healing activity in a rat model. The wound areas of rat skin treated with electrospun gelatin membranes containing C. asiatica (EGC) presented the highest recovery rate compared with those treated with gauze, neat gelatin membranes and commercial wound dressings. The results of the histopathological examination support the outcome of the wound models. Contact‐angle and water‐retention measurements confirmed that the addition of C. asiatica extract did not significantly affect the hydrophilicity of the EGC membranes. The measured weight loss revealed that the EGC membranes are biodegradable. The findings suggest that EGC membranes are a promising material for the treatment of skin wounds. Copyright © 2015 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1932-6254</identifier><identifier>EISSN: 1932-7005</identifier><identifier>DOI: 10.1002/term.1992</identifier><identifier>PMID: 25711743</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Cell Count ; cell proliferation ; Cell Proliferation - drug effects ; Centella asiatica ; Disease Models, Animal ; drug delivery ; electrospinning, nanofibres ; Fibroblasts - cytology ; Fibroblasts - drug effects ; Gelatin - pharmacology ; Male ; Mice ; Nanofibers - chemistry ; Nanofibers - ultrastructure ; Rats, Sprague-Dawley ; Regenerative medicine ; Sus scrofa ; Tissue engineering ; Tissue Engineering - methods ; Triterpenes - pharmacology ; Water ; wound healing ; Wound Healing - drug effects</subject><ispartof>Journal of tissue engineering and regenerative medicine, 2017-03, Vol.11 (3), p.905-915</ispartof><rights>Copyright © 2015 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3522-c20be050647d8b20e591f57e29ffd5e869a413d086cbf4e7d1f0b63e888acf613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fterm.1992$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fterm.1992$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25711743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yao, Chun‐Hsu</creatorcontrib><creatorcontrib>Yeh, Jen‐Yu</creatorcontrib><creatorcontrib>Chen, Yueh‐Sheng</creatorcontrib><creatorcontrib>Li, Ming‐Hsien</creatorcontrib><creatorcontrib>Huang, Chiung‐Hua</creatorcontrib><title>Wound‐healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model</title><title>Journal of tissue engineering and regenerative medicine</title><addtitle>J Tissue Eng Regen Med</addtitle><description>Centella asiatica (CA) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing. This study demonstrated that CA extract facilitates the wound‐repair process by promoting fibroblast proliferation and collagen synthesis and exhibits antibacterial activity. Gelatin nanofibres containing C. asiatica extract were fabricated via electrospinning and were shown to exhibit dermal wound‐healing activity in a rat model. The wound areas of rat skin treated with electrospun gelatin membranes containing C. asiatica (EGC) presented the highest recovery rate compared with those treated with gauze, neat gelatin membranes and commercial wound dressings. The results of the histopathological examination support the outcome of the wound models. Contact‐angle and water‐retention measurements confirmed that the addition of C. asiatica extract did not significantly affect the hydrophilicity of the EGC membranes. The measured weight loss revealed that the EGC membranes are biodegradable. The findings suggest that EGC membranes are a promising material for the treatment of skin wounds. Copyright © 2015 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Cell Count</subject><subject>cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Centella asiatica</subject><subject>Disease Models, Animal</subject><subject>drug delivery</subject><subject>electrospinning, nanofibres</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>Gelatin - pharmacology</subject><subject>Male</subject><subject>Mice</subject><subject>Nanofibers - chemistry</subject><subject>Nanofibers - ultrastructure</subject><subject>Rats, Sprague-Dawley</subject><subject>Regenerative medicine</subject><subject>Sus scrofa</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Triterpenes - pharmacology</subject><subject>Water</subject><subject>wound healing</subject><subject>Wound Healing - drug effects</subject><issn>1932-6254</issn><issn>1932-7005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctKxDAUBuAgiveFLyABN25Gk7S5dCnDeIERQUZclrQ90UqajEmLuvMRfEafxBRHF65c5Sf5ziHJQeiAkhNKCDvtIXQntCjYGtqmRcYmkhC-vsqC8XwL7cT4lDa54Nkm2mJcUirzbBvZez-45vP94xG0bd0DBmOg7rE3GGwKwcfl4PADWN23DjvtvGmrABHX3vW6dWPNFFwP1mqsY5tYrTG89kGnNqlE46B73PkG7B7aMNpG2F-tu-jufLaYXk7mNxdX07P5pM44Y5OakQoIJyKXjaoYAV5QwyWwwpiGgxKFzmnWECXqyuQgG2pIJTJQSunaCJrtouPvvsvgnweIfdm1sR5v6MAPsaRKUSmoKtQ_KBNJEskTPfpDn_wQXHpIUlJIkhMpkjpcqaHqoCmXoe10eCt_vjyB02_w0lp4-z2npBxnWY6zLMdZlovZ7fUYsi_5-ZJd</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Yao, Chun‐Hsu</creator><creator>Yeh, Jen‐Yu</creator><creator>Chen, Yueh‐Sheng</creator><creator>Li, Ming‐Hsien</creator><creator>Huang, Chiung‐Hua</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>201703</creationdate><title>Wound‐healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model</title><author>Yao, Chun‐Hsu ; Yeh, Jen‐Yu ; Chen, Yueh‐Sheng ; Li, Ming‐Hsien ; Huang, Chiung‐Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3522-c20be050647d8b20e591f57e29ffd5e869a413d086cbf4e7d1f0b63e888acf613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Cell Count</topic><topic>cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Centella asiatica</topic><topic>Disease Models, Animal</topic><topic>drug delivery</topic><topic>electrospinning, nanofibres</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - drug effects</topic><topic>Gelatin - pharmacology</topic><topic>Male</topic><topic>Mice</topic><topic>Nanofibers - chemistry</topic><topic>Nanofibers - ultrastructure</topic><topic>Rats, Sprague-Dawley</topic><topic>Regenerative medicine</topic><topic>Sus scrofa</topic><topic>Tissue engineering</topic><topic>Tissue Engineering - methods</topic><topic>Triterpenes - pharmacology</topic><topic>Water</topic><topic>wound healing</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Chun‐Hsu</creatorcontrib><creatorcontrib>Yeh, Jen‐Yu</creatorcontrib><creatorcontrib>Chen, Yueh‐Sheng</creatorcontrib><creatorcontrib>Li, Ming‐Hsien</creatorcontrib><creatorcontrib>Huang, Chiung‐Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Journal of tissue engineering and regenerative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Chun‐Hsu</au><au>Yeh, Jen‐Yu</au><au>Chen, Yueh‐Sheng</au><au>Li, Ming‐Hsien</au><au>Huang, Chiung‐Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wound‐healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model</atitle><jtitle>Journal of tissue engineering and regenerative medicine</jtitle><addtitle>J Tissue Eng Regen Med</addtitle><date>2017-03</date><risdate>2017</risdate><volume>11</volume><issue>3</issue><spage>905</spage><epage>915</epage><pages>905-915</pages><issn>1932-6254</issn><eissn>1932-7005</eissn><abstract>Centella asiatica (CA) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing. This study demonstrated that CA extract facilitates the wound‐repair process by promoting fibroblast proliferation and collagen synthesis and exhibits antibacterial activity. Gelatin nanofibres containing C. asiatica extract were fabricated via electrospinning and were shown to exhibit dermal wound‐healing activity in a rat model. The wound areas of rat skin treated with electrospun gelatin membranes containing C. asiatica (EGC) presented the highest recovery rate compared with those treated with gauze, neat gelatin membranes and commercial wound dressings. The results of the histopathological examination support the outcome of the wound models. Contact‐angle and water‐retention measurements confirmed that the addition of C. asiatica extract did not significantly affect the hydrophilicity of the EGC membranes. The measured weight loss revealed that the EGC membranes are biodegradable. The findings suggest that EGC membranes are a promising material for the treatment of skin wounds. Copyright © 2015 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>25711743</pmid><doi>10.1002/term.1992</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - pharmacology Cell Count cell proliferation Cell Proliferation - drug effects Centella asiatica Disease Models, Animal drug delivery electrospinning, nanofibres Fibroblasts - cytology Fibroblasts - drug effects Gelatin - pharmacology Male Mice Nanofibers - chemistry Nanofibers - ultrastructure Rats, Sprague-Dawley Regenerative medicine Sus scrofa Tissue engineering Tissue Engineering - methods Triterpenes - pharmacology Water wound healing Wound Healing - drug effects |
| title | Wound‐healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model |
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