The MACC1-SPON2 axis: a new biomarker and therapeutic target in colorectal cancer

In this issue of the Journal, Schmid et al identify Spondin 2 (SPON2) as a prominent downstream signaling target of metastasis-associated in colon cancer 1 (MACC1) in colorectal cancer (CRC). It is shown that SPON2 mediates MACC1-induced CRC cell proliferation, invasion and metastasis in vitro and i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2017-03, Vol.36 (11), p.1474-1475
Hauptverfasser:	Chandrasinghe, P, Stebbing, J, Warusavitarne, J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/67 Apoptosis Biomarkers Biomarkers, Tumor Carcinogenesis Care and treatment Cell Biology Cell proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cellular proteins Cellular signal transduction Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology commentary Development and progression Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Human Genetics Humans Innovations Internal Medicine Medicine Medicine & Public Health Metastases Metastasis Molecular targeted therapy Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncology Prognosis Protein expression Signal Transduction Solid tumors Therapeutic applications Therapeutic targets Trans-Activators Transcription Factors - genetics Transcription Factors - metabolism Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!