Interleukin-18-induced cell adhesion molecule expression is associated with feedback regulation by PPAR-γ and NF-κB in Apo E−/− mice

Focal recruitment of monocytes and lymphocytes is one of the earliest detectable cellular responses in atherosclerotic lesion formation. Endothelium may regulate leukocyte recruitment by expressing specific adhesion molecules. Interleukin-18 is a proinflammatory cytokine that plays an important role...

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Veröffentlicht in:	Molecular and cellular biochemistry 2017-04, Vol.428 (1-2), p.119-128
Hauptverfasser:	Bhat, Owais Mohammad, Uday Kumar, P., Harishankar, N., Ravichandaran, L., Bhatia, A., Dhawan, Veena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Atherosclerosis - genetics Biochemistry Biomedical and Life Sciences Cardiology Cell Adhesion - drug effects Cell Adhesion Molecules - genetics Cell Adhesion Molecules - pharmacology Disease Models, Animal Feedback, Physiological - drug effects Gene Expression Regulation Humans Interleukin-18 - administration & dosage Interleukin-18 - pharmacology Life Sciences Male Medical Biochemistry Mice Mice, Knockout NF-kappa B - genetics NF-kappa B - metabolism Oncology PPAR gamma - genetics PPAR gamma - metabolism Signal Transduction
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