An EP4 Receptor Agonist Inhibits Cardiac Fibrosis Through Activation of PKA Signaling in Hypertrophied Heart

Cardiac fibrosis is a pathological feature of myocardium of failing heart and plays causative roles in arrhythmia and cardiac dysfunction, but its regulatory mechanisms remain largely elusive. In this study, we investigated the effects of the novel EP4 receptor agonist ONO-0260164 on cardiac fibrosi...

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Veröffentlicht in:	International Heart Journal 2017, Vol.58(1), pp.107-114
Hauptverfasser:	Wang, Qi, Oka, Toru, Yamagami, Kiyoshi, Lee, Jong-Kook, Akazawa, Hiroshi, Naito, Atsuhiko T., Yasui, Taku, Ishizu, Takamaru, Nakaoka, Yoshikazu, Sakata, Yasushi, Komuro, Issei
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Aorta Arrhythmia Cardiac fibroblasts Cardiomegaly - drug therapy Cardiomegaly - metabolism Cardiomegaly - pathology Collagen Collagen (type I) Collagen - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Disease Models, Animal EP4 agonist Fibroblasts Fibrosis Heart - drug effects Hypertrophy Kinases Male Mice, Inbred C57BL Myocardium Myocardium - pathology Neonates Protein kinase A Random Allocation Receptors, Prostaglandin E, EP4 Subtype - agonists Transforming growth factor Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1
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