Predictive markers for delayed lymph node metastases and survival in early‐stage oral squamous cell carcinoma
ABSTRACT Background The purpose of this study was to identify clinicopathological and immunohistochemical factors predicting delayed lymph node metastases and survival in early oral squamous cell carcinoma (OSCC). Methods The study included 85 consecutive patients with clinically T1 to T2N0 OSCC who...
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| Veröffentlicht in: | Head & neck 2017-04, Vol.39 (4), p.694-701 |
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| creator | Luksic, Ivica Suton, Petar |
| description | ABSTRACT
Background
The purpose of this study was to identify clinicopathological and immunohistochemical factors predicting delayed lymph node metastases and survival in early oral squamous cell carcinoma (OSCC).
Methods
The study included 85 consecutive patients with clinically T1 to T2N0 OSCC who were primarily surgically treated between 2000 and 2004.
Results
There were 68 men and 17 women (median age, 61 years; range, 34–82 years). Of all the patients, 25 (29.4%) developed delayed lymph node metastases within 3 to 42 months after treatment of the primary tumor. Multivariate logistic regression analysis identified poorly differentiated tumors, low laminin, and high fibronectin expression as prognosticators of delayed lymph node metastases. Cox's proportional hazards regression analysis demonstrated that moderately differentiated tumors and delayed lymph node metastases had predictive value regarding survival.
Conclusion
Large prospective investigations with reproducibility and the clinical translatability of immunohistochemical methods are needed in order to provide new and effective therapeutic strategies in the future. © 2016 Wiley Periodicals, Inc. Head Neck 39: 694–701, 2017 |
| doi_str_mv | 10.1002/hed.24667 |
| format | Article |
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Background
The purpose of this study was to identify clinicopathological and immunohistochemical factors predicting delayed lymph node metastases and survival in early oral squamous cell carcinoma (OSCC).
Methods
The study included 85 consecutive patients with clinically T1 to T2N0 OSCC who were primarily surgically treated between 2000 and 2004.
Results
There were 68 men and 17 women (median age, 61 years; range, 34–82 years). Of all the patients, 25 (29.4%) developed delayed lymph node metastases within 3 to 42 months after treatment of the primary tumor. Multivariate logistic regression analysis identified poorly differentiated tumors, low laminin, and high fibronectin expression as prognosticators of delayed lymph node metastases. Cox's proportional hazards regression analysis demonstrated that moderately differentiated tumors and delayed lymph node metastases had predictive value regarding survival.
Conclusion
Large prospective investigations with reproducibility and the clinical translatability of immunohistochemical methods are needed in order to provide new and effective therapeutic strategies in the future. © 2016 Wiley Periodicals, Inc. Head Neck 39: 694–701, 2017</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.24667</identifier><identifier>PMID: 28006084</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Biopsy, Needle ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; Cohort Studies ; delayed lymph node metastases ; Disease-Free Survival ; Female ; Fibronectins - analysis ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Laminin - analysis ; Lymph Nodes - pathology ; Lymphatic Metastasis - pathology ; Male ; Middle Aged ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Mouth Neoplasms - therapy ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; oral cancer ; Predictive Value of Tests ; Prognosis ; prognostic factors ; Proportional Hazards Models ; recurrence ; Retrospective Studies ; survival ; Survival Analysis</subject><ispartof>Head & neck, 2017-04, Vol.39 (4), p.694-701</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-9138-2037</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.24667$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.24667$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28006084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luksic, Ivica</creatorcontrib><creatorcontrib>Suton, Petar</creatorcontrib><title>Predictive markers for delayed lymph node metastases and survival in early‐stage oral squamous cell carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>ABSTRACT
Background
The purpose of this study was to identify clinicopathological and immunohistochemical factors predicting delayed lymph node metastases and survival in early oral squamous cell carcinoma (OSCC).
Methods
The study included 85 consecutive patients with clinically T1 to T2N0 OSCC who were primarily surgically treated between 2000 and 2004.
Results
There were 68 men and 17 women (median age, 61 years; range, 34–82 years). Of all the patients, 25 (29.4%) developed delayed lymph node metastases within 3 to 42 months after treatment of the primary tumor. Multivariate logistic regression analysis identified poorly differentiated tumors, low laminin, and high fibronectin expression as prognosticators of delayed lymph node metastases. Cox's proportional hazards regression analysis demonstrated that moderately differentiated tumors and delayed lymph node metastases had predictive value regarding survival.
Conclusion
Large prospective investigations with reproducibility and the clinical translatability of immunohistochemical methods are needed in order to provide new and effective therapeutic strategies in the future. © 2016 Wiley Periodicals, Inc. Head Neck 39: 694–701, 2017</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Cohort Studies</subject><subject>delayed lymph node metastases</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Fibronectins - analysis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Laminin - analysis</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - therapy</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>oral cancer</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>prognostic factors</subject><subject>Proportional Hazards Models</subject><subject>recurrence</subject><subject>Retrospective Studies</subject><subject>survival</subject><subject>Survival Analysis</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkclOxDAMhiMEYhk48AIoEhcuZZylSXpE7BISHOBcZRqXKXSZSaaDeuMReEaehAzbgROSJVv-P1m2f0L2GRwzAD6eojvmUim9RrYZZDoBIfX6qpYiEaDlFtkJ4QkAhJJ8k2xxA6DAyG3S3Xl0VbGolkgb65_RB1p2njqs7YCO1kMzm9K2c1HGhQ0xMFDbOhp6v6yWtqZVS9H6enh_fYvyI9LOx26Y97bp-kALrGtaWF9UbdfYXbJR2jrg3ncekYeL8_vTq-Tm9vL69OQmmXHJdTJh0qTIuZWFBFY6rYApnprSOuaAT5QqJwyNBGUyDro0WmTCFYUsHRRCSzEiR19zZ76b9xgWeVOF1Sq2xbhVzoxhOjVaq3-gKdeGpwwievgHfep638ZDIqXTTINSWaQOvql-0qDLZ76Krx3yn69HYPwFvFQ1Dr86g3xlZx7tzD_tzK_Ozz4L8QG8tpIy</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Luksic, Ivica</creator><creator>Suton, Petar</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9138-2037</orcidid></search><sort><creationdate>201704</creationdate><title>Predictive markers for delayed lymph node metastases and survival in early‐stage oral squamous cell carcinoma</title><author>Luksic, Ivica ; Suton, Petar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2427-b1485e22a4c401fd76016258fad1d02b66fb1e840689207f87393dcc4fd0c3743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Cohort Studies</topic><topic>delayed lymph node metastases</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Fibronectins - analysis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Laminin - analysis</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - therapy</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>oral cancer</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>prognostic factors</topic><topic>Proportional Hazards Models</topic><topic>recurrence</topic><topic>Retrospective Studies</topic><topic>survival</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luksic, Ivica</creatorcontrib><creatorcontrib>Suton, Petar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luksic, Ivica</au><au>Suton, Petar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive markers for delayed lymph node metastases and survival in early‐stage oral squamous cell carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2017-04</date><risdate>2017</risdate><volume>39</volume><issue>4</issue><spage>694</spage><epage>701</epage><pages>694-701</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>ABSTRACT
Background
The purpose of this study was to identify clinicopathological and immunohistochemical factors predicting delayed lymph node metastases and survival in early oral squamous cell carcinoma (OSCC).
Methods
The study included 85 consecutive patients with clinically T1 to T2N0 OSCC who were primarily surgically treated between 2000 and 2004.
Results
There were 68 men and 17 women (median age, 61 years; range, 34–82 years). Of all the patients, 25 (29.4%) developed delayed lymph node metastases within 3 to 42 months after treatment of the primary tumor. Multivariate logistic regression analysis identified poorly differentiated tumors, low laminin, and high fibronectin expression as prognosticators of delayed lymph node metastases. Cox's proportional hazards regression analysis demonstrated that moderately differentiated tumors and delayed lymph node metastases had predictive value regarding survival.
Conclusion
Large prospective investigations with reproducibility and the clinical translatability of immunohistochemical methods are needed in order to provide new and effective therapeutic strategies in the future. © 2016 Wiley Periodicals, Inc. Head Neck 39: 694–701, 2017</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28006084</pmid><doi>10.1002/hed.24667</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9138-2037</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Biopsy, Needle Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cohort Studies delayed lymph node metastases Disease-Free Survival Female Fibronectins - analysis Humans Immunohistochemistry Kaplan-Meier Estimate Laminin - analysis Lymph Nodes - pathology Lymphatic Metastasis - pathology Male Middle Aged Mouth Neoplasms - mortality Mouth Neoplasms - pathology Mouth Neoplasms - therapy Neoplasm Invasiveness - pathology Neoplasm Staging oral cancer Predictive Value of Tests Prognosis prognostic factors Proportional Hazards Models recurrence Retrospective Studies survival Survival Analysis |
| title | Predictive markers for delayed lymph node metastases and survival in early‐stage oral squamous cell carcinoma |
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