IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma

We analysed the influence of rhinovirus (RV) in nasopharyngeal fluid (NPF) on type I and III interferon (IFN) responses (e.g. IFN-α and IFN -: λ) and their signal transduction, at baseline and during disease exacerbation, in cohorts of pre-school children with and without asthma.At the time of recru...

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Veröffentlicht in:	The European respiratory journal 2017-02, Vol.49 (2), p.1600969-1600969
Hauptverfasser:	Bergauer, Annika, Sopel, Nina, Kroß, Bettina, Vuorinen, Tytti, Xepapadaki, Paraskevi, Weiss, Scott T, Blau, Ashley, Sharma, Himanshu, Kraus, Cornelia, Springel, Rebekka, Rauh, Manfred, Mittler, Susanne, Graser, Anna, Zimmermann, Theodor, Melichar, Volker O, Kiefer, Alexander, Kowalski, Marek L, Sobanska, Anna, Jartti, Tuomas, Lukkarinen, Heikki, Papadopoulos, Nikolaos G, Finotto, Susetta
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma Asthma - immunology Asthma - virology C-reactive protein C-Reactive Protein - analysis Cells, Cultured Child, Preschool Children Disease Progression Enterovirus Enzyme-linked immunosorbent assay Europe Female Humans Immune response Interferon Interferon regulatory factor 1 Interferon Regulatory Factor-1 - genetics Interferons - blood Interferons - immunology Leukocytes (mononuclear) Leukocytes, Mononuclear - virology Male mRNA MyD88 protein Myeloid Differentiation Factor 88 - genetics Nasopharynx - virology Peripheral blood mononuclear cells Picornaviridae Picornaviridae Infections - immunology Prospective Studies Rhinovirus RNA, Messenger - analysis Signal Transduction Stat1 protein STAT1 Transcription Factor - genetics Stat2 protein STAT2 Transcription Factor - genetics Transduction
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