A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats
Diabetes mellitus (DM) is characterized by hyperglycemia due to insulin inactivity or insufficiency with increasing risk of developing specific complications, including retinopathy, nephropathy, neuropathy, and atherosclerosis. The aim of the present study is to evaluate the efficacy of coenzyme Q10...
Gespeichert in:
| Veröffentlicht in: | Molecular neurobiology 2017-04, Vol.54 (3), p.1601-1611 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1611 |
|---|---|
| container_issue | 3 |
| container_start_page | 1601 |
| container_title | Molecular neurobiology |
| container_volume | 54 |
| creator | Motawi, Tarek K. Darwish, Hebatallah A. Hamed, Manal A. El-Rigal, Nagy S. Naser, Asmaa F. Aboul |
| description | Diabetes mellitus (DM) is characterized by hyperglycemia due to insulin inactivity or insufficiency with increasing risk of developing specific complications, including retinopathy, nephropathy, neuropathy, and atherosclerosis. The aim of the present study is to evaluate the efficacy of coenzyme Q10 (CoQ10), niacin, as well as their combination in ameliorating brain disorders associated with streptozotocin (STZ)-induced diabetes in rats. Glibenclamide, a reference diabetic drug, and donepezil, an acetylcholine inhibitor drug, were also evaluated. Diabetes was induced by single intraperitoneal injection of STZ (60 mg/kg body weight (b.wt)). One-month diabetic rats were treated with the selected drugs daily for another two consecutive weeks. The evaluation was done through the estimation of the levels of blood glucose, serum insulin, and oxidative stress markers: malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH); neurotransmitters: acetylcholine (Ach) and dopamine (DA); vasoconstrictor indices: intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and angiotensin II (Ang II); and apoptosis markers: tumor necrosis factor-α (TNF-α) and caspase-3 as well as the histopathological picture of the cerebellum region of the brain. The results revealed that the combination of niacin and CoQ10 improved most of the measured parameters with variable degrees. In conclusion, niacin and CoQ10 are promising dietary supplements in the management of diabetic encephalopathy. |
| doi_str_mv | 10.1007/s12035-016-9765-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1881758518</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826656950</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-d8fe75d0519b46ebb5891e1c5c77775032802273050fd1bffae4e931ec259b043</originalsourceid><addsrcrecordid>eNqNkU1r3DAQhkVpabbb_oBeiiCXXJzMyNaHj8smbQIhJSGF3oQsj3cddmXHsiGbX18tm5RSKFQXHfS874x4GPuMcIoA-iyigFxmgCortZLZ0xs2QynLDNGIt2wGpswzrQpzxD7E-AAgBIJ-z46EMioF5Iz9XPD7NQ2up2lsPb8KsV2tR941_KZ1vg3chZovOwrPuy3xWwS-WLk2xJGft66ifeYieOrXbtP1blzveMrcuTF-ZO8at4n06eWesx9fL-6Xl9n1929Xy8V15guQY1abhrSsQWJZFYqqSpoSCb30Oh0JuTBpa52DhKbGqmkcFVTmSF7IsoIin7OTQ28_dI8TxdFu2-hps3GBuilaNAa1NBLNf6BCKanKNHXOjv9CH7ppCOkjidIGpEpwovBA-aGLcaDG9kO7dcPOIti9IXswZJMhuzdkn1Lmy0vzVG2p_p14VZIAcQBiegorGv4Y_c_WXzBNmXU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1878056182</pqid></control><display><type>article</type><title>A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Motawi, Tarek K. ; Darwish, Hebatallah A. ; Hamed, Manal A. ; El-Rigal, Nagy S. ; Naser, Asmaa F. Aboul</creator><creatorcontrib>Motawi, Tarek K. ; Darwish, Hebatallah A. ; Hamed, Manal A. ; El-Rigal, Nagy S. ; Naser, Asmaa F. Aboul</creatorcontrib><description>Diabetes mellitus (DM) is characterized by hyperglycemia due to insulin inactivity or insufficiency with increasing risk of developing specific complications, including retinopathy, nephropathy, neuropathy, and atherosclerosis. The aim of the present study is to evaluate the efficacy of coenzyme Q10 (CoQ10), niacin, as well as their combination in ameliorating brain disorders associated with streptozotocin (STZ)-induced diabetes in rats. Glibenclamide, a reference diabetic drug, and donepezil, an acetylcholine inhibitor drug, were also evaluated. Diabetes was induced by single intraperitoneal injection of STZ (60 mg/kg body weight (b.wt)). One-month diabetic rats were treated with the selected drugs daily for another two consecutive weeks. The evaluation was done through the estimation of the levels of blood glucose, serum insulin, and oxidative stress markers: malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH); neurotransmitters: acetylcholine (Ach) and dopamine (DA); vasoconstrictor indices: intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and angiotensin II (Ang II); and apoptosis markers: tumor necrosis factor-α (TNF-α) and caspase-3 as well as the histopathological picture of the cerebellum region of the brain. The results revealed that the combination of niacin and CoQ10 improved most of the measured parameters with variable degrees. In conclusion, niacin and CoQ10 are promising dietary supplements in the management of diabetic encephalopathy.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-016-9765-x</identifier><identifier>PMID: 26867655</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Apoptosis ; Biomedical and Life Sciences ; Biomedicine ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Brain Diseases - blood ; Brain Diseases - drug therapy ; Brain Diseases - pathology ; Cell adhesion & migration ; Cell Biology ; Diabetes ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - pathology ; Diabetic neuropathy ; Drug Therapy, Combination ; Hyperglycemia ; Intercellular Adhesion Molecule-1 - blood ; Male ; Neurobiology ; Neurology ; Neurosciences ; Neurotransmitters ; Niacin - administration & dosage ; Oxidative stress ; Rats ; Rats, Wistar ; Ubiquinone - administration & dosage ; Ubiquinone - analogs & derivatives ; Vascular Cell Adhesion Molecule-1 - blood ; Vitamin B ; Vitamin B Complex - administration & dosage</subject><ispartof>Molecular neurobiology, 2017-04, Vol.54 (3), p.1601-1611</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Molecular Neurobiology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-d8fe75d0519b46ebb5891e1c5c77775032802273050fd1bffae4e931ec259b043</citedby><cites>FETCH-LOGICAL-c405t-d8fe75d0519b46ebb5891e1c5c77775032802273050fd1bffae4e931ec259b043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-016-9765-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-016-9765-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26867655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motawi, Tarek K.</creatorcontrib><creatorcontrib>Darwish, Hebatallah A.</creatorcontrib><creatorcontrib>Hamed, Manal A.</creatorcontrib><creatorcontrib>El-Rigal, Nagy S.</creatorcontrib><creatorcontrib>Naser, Asmaa F. Aboul</creatorcontrib><title>A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Diabetes mellitus (DM) is characterized by hyperglycemia due to insulin inactivity or insufficiency with increasing risk of developing specific complications, including retinopathy, nephropathy, neuropathy, and atherosclerosis. The aim of the present study is to evaluate the efficacy of coenzyme Q10 (CoQ10), niacin, as well as their combination in ameliorating brain disorders associated with streptozotocin (STZ)-induced diabetes in rats. Glibenclamide, a reference diabetic drug, and donepezil, an acetylcholine inhibitor drug, were also evaluated. Diabetes was induced by single intraperitoneal injection of STZ (60 mg/kg body weight (b.wt)). One-month diabetic rats were treated with the selected drugs daily for another two consecutive weeks. The evaluation was done through the estimation of the levels of blood glucose, serum insulin, and oxidative stress markers: malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH); neurotransmitters: acetylcholine (Ach) and dopamine (DA); vasoconstrictor indices: intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and angiotensin II (Ang II); and apoptosis markers: tumor necrosis factor-α (TNF-α) and caspase-3 as well as the histopathological picture of the cerebellum region of the brain. The results revealed that the combination of niacin and CoQ10 improved most of the measured parameters with variable degrees. In conclusion, niacin and CoQ10 are promising dietary supplements in the management of diabetic encephalopathy.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Brain Diseases - blood</subject><subject>Brain Diseases - drug therapy</subject><subject>Brain Diseases - pathology</subject><subject>Cell adhesion & migration</subject><subject>Cell Biology</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetic neuropathy</subject><subject>Drug Therapy, Combination</subject><subject>Hyperglycemia</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Male</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurotransmitters</subject><subject>Niacin - administration & dosage</subject><subject>Oxidative stress</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Ubiquinone - administration & dosage</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><subject>Vitamin B</subject><subject>Vitamin B Complex - administration & dosage</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1r3DAQhkVpabbb_oBeiiCXXJzMyNaHj8smbQIhJSGF3oQsj3cddmXHsiGbX18tm5RSKFQXHfS874x4GPuMcIoA-iyigFxmgCortZLZ0xs2QynLDNGIt2wGpswzrQpzxD7E-AAgBIJ-z46EMioF5Iz9XPD7NQ2up2lsPb8KsV2tR941_KZ1vg3chZovOwrPuy3xWwS-WLk2xJGft66ifeYieOrXbtP1blzveMrcuTF-ZO8at4n06eWesx9fL-6Xl9n1929Xy8V15guQY1abhrSsQWJZFYqqSpoSCb30Oh0JuTBpa52DhKbGqmkcFVTmSF7IsoIin7OTQ28_dI8TxdFu2-hps3GBuilaNAa1NBLNf6BCKanKNHXOjv9CH7ppCOkjidIGpEpwovBA-aGLcaDG9kO7dcPOIti9IXswZJMhuzdkn1Lmy0vzVG2p_p14VZIAcQBiegorGv4Y_c_WXzBNmXU</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Motawi, Tarek K.</creator><creator>Darwish, Hebatallah A.</creator><creator>Hamed, Manal A.</creator><creator>El-Rigal, Nagy S.</creator><creator>Naser, Asmaa F. Aboul</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats</title><author>Motawi, Tarek K. ; Darwish, Hebatallah A. ; Hamed, Manal A. ; El-Rigal, Nagy S. ; Naser, Asmaa F. Aboul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-d8fe75d0519b46ebb5891e1c5c77775032802273050fd1bffae4e931ec259b043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Brain Diseases - blood</topic><topic>Brain Diseases - drug therapy</topic><topic>Brain Diseases - pathology</topic><topic>Cell adhesion & migration</topic><topic>Cell Biology</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetic neuropathy</topic><topic>Drug Therapy, Combination</topic><topic>Hyperglycemia</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Male</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Neurotransmitters</topic><topic>Niacin - administration & dosage</topic><topic>Oxidative stress</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Ubiquinone - administration & dosage</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><topic>Vitamin B</topic><topic>Vitamin B Complex - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motawi, Tarek K.</creatorcontrib><creatorcontrib>Darwish, Hebatallah A.</creatorcontrib><creatorcontrib>Hamed, Manal A.</creatorcontrib><creatorcontrib>El-Rigal, Nagy S.</creatorcontrib><creatorcontrib>Naser, Asmaa F. Aboul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motawi, Tarek K.</au><au>Darwish, Hebatallah A.</au><au>Hamed, Manal A.</au><au>El-Rigal, Nagy S.</au><au>Naser, Asmaa F. Aboul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>54</volume><issue>3</issue><spage>1601</spage><epage>1611</epage><pages>1601-1611</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Diabetes mellitus (DM) is characterized by hyperglycemia due to insulin inactivity or insufficiency with increasing risk of developing specific complications, including retinopathy, nephropathy, neuropathy, and atherosclerosis. The aim of the present study is to evaluate the efficacy of coenzyme Q10 (CoQ10), niacin, as well as their combination in ameliorating brain disorders associated with streptozotocin (STZ)-induced diabetes in rats. Glibenclamide, a reference diabetic drug, and donepezil, an acetylcholine inhibitor drug, were also evaluated. Diabetes was induced by single intraperitoneal injection of STZ (60 mg/kg body weight (b.wt)). One-month diabetic rats were treated with the selected drugs daily for another two consecutive weeks. The evaluation was done through the estimation of the levels of blood glucose, serum insulin, and oxidative stress markers: malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH); neurotransmitters: acetylcholine (Ach) and dopamine (DA); vasoconstrictor indices: intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and angiotensin II (Ang II); and apoptosis markers: tumor necrosis factor-α (TNF-α) and caspase-3 as well as the histopathological picture of the cerebellum region of the brain. The results revealed that the combination of niacin and CoQ10 improved most of the measured parameters with variable degrees. In conclusion, niacin and CoQ10 are promising dietary supplements in the management of diabetic encephalopathy.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26867655</pmid><doi>10.1007/s12035-016-9765-x</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-7648 |
| ispartof | Molecular neurobiology, 2017-04, Vol.54 (3), p.1601-1611 |
| issn | 0893-7648 1559-1182 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1881758518 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Apoptosis Biomedical and Life Sciences Biomedicine Blood Glucose - drug effects Blood Glucose - metabolism Brain Diseases - blood Brain Diseases - drug therapy Brain Diseases - pathology Cell adhesion & migration Cell Biology Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Diabetic neuropathy Drug Therapy, Combination Hyperglycemia Intercellular Adhesion Molecule-1 - blood Male Neurobiology Neurology Neurosciences Neurotransmitters Niacin - administration & dosage Oxidative stress Rats Rats, Wistar Ubiquinone - administration & dosage Ubiquinone - analogs & derivatives Vascular Cell Adhesion Molecule-1 - blood Vitamin B Vitamin B Complex - administration & dosage |
| title | A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T11%3A31%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Therapeutic%20Insight%20of%20Niacin%20and%20Coenzyme%20Q10%20Against%20Diabetic%20Encephalopathy%20in%20Rats&rft.jtitle=Molecular%20neurobiology&rft.au=Motawi,%20Tarek%20K.&rft.date=2017-04-01&rft.volume=54&rft.issue=3&rft.spage=1601&rft.epage=1611&rft.pages=1601-1611&rft.issn=0893-7648&rft.eissn=1559-1182&rft_id=info:doi/10.1007/s12035-016-9765-x&rft_dat=%3Cproquest_cross%3E1826656950%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1878056182&rft_id=info:pmid/26867655&rfr_iscdi=true |