Assessment of Early Evidence of Multiple Sclerosis in a Prospective Study of Asymptomatic High-Risk Family Members

IMPORTANCE: Subclinical inflammatory demyelination and neurodegeneration often precede symptom onset in multiple sclerosis (MS). OBJECTIVE: To investigate the prevalence of brain magnetic resonance imaging (MRI) and subclinical abnormalities among asymptomatic individuals at risk for MS. DESIGN, SET...

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Veröffentlicht in:	JAMA neurology 2017-03, Vol.74 (3), p.293-300
Hauptverfasser:	Xia, Zongqi, Steele, Sonya U, Bakshi, Anshika, Clarkson, Sarah R, White, Charles C, Schindler, Matthew K, Nair, Govind, Dewey, Blake E, Price, Lauren R, Ohayon, Joan, Chibnik, Lori B, Cortese, Irene C. M, De Jager, Philip L, Reich, Daniel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Brain - diagnostic imaging Chi-Square Distribution Cohort Studies Disability Evaluation Family Health Female Humans Imaging, Three-Dimensional Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis - complications Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - epidemiology Multiple Sclerosis - genetics Nervous System Diseases - etiology Young Adult
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