Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin
ABSTRACT Background The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC). Methods This was a prospective phase II study. The primary endpoint was complete response (CR)....
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| Veröffentlicht in: | Head & neck 2017-04, Vol.39 (4), p.679-683 |
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| creator | Nottage, Michelle K. Lin, Charles Hughes, Brett G. M. Kenny, Lizbeth Smith, David D. Houston, Kathleen Francesconi, Alessandra |
| description | ABSTRACT
Background
The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC).
Methods
This was a prospective phase II study. The primary endpoint was complete response (CR). Patients with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly platinum‐based chemotherapy (cisplatin 40 mg/m2 or carboplatin area under the curve 2).
Results
Twenty‐one patients were enrolled in this study. Eighteen patients had a locally advanced primary or nodal disease in the head and neck region with 66% having stage IV nonmetastatic disease. Of 19 evaluable patients, 10 achieved a CR to definitive CRT with 2 further patients rendered disease‐free by salvage surgery for an overall CR of 63%.
Conclusion
This is the only prospective series of CRT for cutaneous SCC. A high CR rate was documented in patients with locoregional advanced disease who were unable to undergo surgery. © 2016 Wiley Periodicals, Inc. Head Neck 39: 679–683, 2017 |
| doi_str_mv | 10.1002/hed.24662 |
| format | Article |
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Background
The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC).
Methods
This was a prospective phase II study. The primary endpoint was complete response (CR). Patients with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly platinum‐based chemotherapy (cisplatin 40 mg/m2 or carboplatin area under the curve 2).
Results
Twenty‐one patients were enrolled in this study. Eighteen patients had a locally advanced primary or nodal disease in the head and neck region with 66% having stage IV nonmetastatic disease. Of 19 evaluable patients, 10 achieved a CR to definitive CRT with 2 further patients rendered disease‐free by salvage surgery for an overall CR of 63%.
Conclusion
This is the only prospective series of CRT for cutaneous SCC. A high CR rate was documented in patients with locoregional advanced disease who were unable to undergo surgery. © 2016 Wiley Periodicals, Inc. Head Neck 39: 679–683, 2017</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.24662</identifier><identifier>PMID: 28032670</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; carcinoma ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; chemoradiotherapy ; Chemoradiotherapy - methods ; Confidence Intervals ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Prognosis ; Prospective Studies ; Radiotherapy Dosage ; Risk Assessment ; skin neoplasms ; Skin Neoplasms - mortality ; Skin Neoplasms - pathology ; Skin Neoplasms - therapy ; squamous cell ; Survival Analysis ; Treatment Outcome</subject><ispartof>Head & neck, 2017-04, Vol.39 (4), p.679-683</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3522-5c6eda774faf67a1a099e1169f445a295c963e658f5e37157d1005ecd790d4fb3</citedby><orcidid>0000-0002-1620-1961</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.24662$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.24662$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28032670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nottage, Michelle K.</creatorcontrib><creatorcontrib>Lin, Charles</creatorcontrib><creatorcontrib>Hughes, Brett G. M.</creatorcontrib><creatorcontrib>Kenny, Lizbeth</creatorcontrib><creatorcontrib>Smith, David D.</creatorcontrib><creatorcontrib>Houston, Kathleen</creatorcontrib><creatorcontrib>Francesconi, Alessandra</creatorcontrib><title>Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>ABSTRACT
Background
The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC).
Methods
This was a prospective phase II study. The primary endpoint was complete response (CR). Patients with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly platinum‐based chemotherapy (cisplatin 40 mg/m2 or carboplatin area under the curve 2).
Results
Twenty‐one patients were enrolled in this study. Eighteen patients had a locally advanced primary or nodal disease in the head and neck region with 66% having stage IV nonmetastatic disease. Of 19 evaluable patients, 10 achieved a CR to definitive CRT with 2 further patients rendered disease‐free by salvage surgery for an overall CR of 63%.
Conclusion
This is the only prospective series of CRT for cutaneous SCC. A high CR rate was documented in patients with locoregional advanced disease who were unable to undergo surgery. © 2016 Wiley Periodicals, Inc. Head Neck 39: 679–683, 2017</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>carcinoma</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>chemoradiotherapy</subject><subject>Chemoradiotherapy - methods</subject><subject>Confidence Intervals</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Radiotherapy Dosage</subject><subject>Risk Assessment</subject><subject>skin neoplasms</subject><subject>Skin Neoplasms - mortality</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - therapy</subject><subject>squamous cell</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq0KVCjtgT9QWeLCJez4e3OsKBQkJDjAOTL2pGtI4sVOqPbf19mlHHrhMPJ45tHM6H0JOWZwxgD4YoX-jEut-SdyyKA2FQhp9uZcikqAkQfkS85PACC05J_JAV-C4NrAIRnvUsxrdGN4RZrHyW9obKnHNgxhW3Mr7GOyPtgxxIGGgXbR2a4rXKIJf5fi9mf9qx0ceppfJtvHKVOHXUedTS4Msbfz2HFVdjyH4SvZb22X8dvbe0QeLi_uz6-qm9tf1-c_bionFOeVchq9NUa2ttXGMgt1jYzpupVSWV4rV2uBWi1bhcIwZXxRQ6HzpgYv20dxRE53c9cpvkyYx6YPeT7LDlgubNhyyYwSvMTHqJIMDEhZ0JP_0Kc4paLCTBlVGzCMF-r7GzU99uibdQq9TZvmn_QFWOyAP6HDzXufQTN72hRPm62nzdXFz20i_gJ5qpOH</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Nottage, Michelle K.</creator><creator>Lin, Charles</creator><creator>Hughes, Brett G. M.</creator><creator>Kenny, Lizbeth</creator><creator>Smith, David D.</creator><creator>Houston, Kathleen</creator><creator>Francesconi, Alessandra</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1620-1961</orcidid></search><sort><creationdate>201704</creationdate><title>Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin</title><author>Nottage, Michelle K. ; Lin, Charles ; Hughes, Brett G. M. ; Kenny, Lizbeth ; Smith, David D. ; Houston, Kathleen ; Francesconi, Alessandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3522-5c6eda774faf67a1a099e1169f445a295c963e658f5e37157d1005ecd790d4fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>carcinoma</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>chemoradiotherapy</topic><topic>Chemoradiotherapy - methods</topic><topic>Confidence Intervals</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Radiotherapy Dosage</topic><topic>Risk Assessment</topic><topic>skin neoplasms</topic><topic>Skin Neoplasms - mortality</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - therapy</topic><topic>squamous cell</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nottage, Michelle K.</creatorcontrib><creatorcontrib>Lin, Charles</creatorcontrib><creatorcontrib>Hughes, Brett G. M.</creatorcontrib><creatorcontrib>Kenny, Lizbeth</creatorcontrib><creatorcontrib>Smith, David D.</creatorcontrib><creatorcontrib>Houston, Kathleen</creatorcontrib><creatorcontrib>Francesconi, Alessandra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nottage, Michelle K.</au><au>Lin, Charles</au><au>Hughes, Brett G. M.</au><au>Kenny, Lizbeth</au><au>Smith, David D.</au><au>Houston, Kathleen</au><au>Francesconi, Alessandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2017-04</date><risdate>2017</risdate><volume>39</volume><issue>4</issue><spage>679</spage><epage>683</epage><pages>679-683</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>ABSTRACT
Background
The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC).
Methods
This was a prospective phase II study. The primary endpoint was complete response (CR). Patients with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly platinum‐based chemotherapy (cisplatin 40 mg/m2 or carboplatin area under the curve 2).
Results
Twenty‐one patients were enrolled in this study. Eighteen patients had a locally advanced primary or nodal disease in the head and neck region with 66% having stage IV nonmetastatic disease. Of 19 evaluable patients, 10 achieved a CR to definitive CRT with 2 further patients rendered disease‐free by salvage surgery for an overall CR of 63%.
Conclusion
This is the only prospective series of CRT for cutaneous SCC. A high CR rate was documented in patients with locoregional advanced disease who were unable to undergo surgery. © 2016 Wiley Periodicals, Inc. Head Neck 39: 679–683, 2017</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28032670</pmid><doi>10.1002/hed.24662</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-1620-1961</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use carcinoma Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy chemoradiotherapy Chemoradiotherapy - methods Confidence Intervals Disease-Free Survival Female Humans Kaplan-Meier Estimate Male Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging Prognosis Prospective Studies Radiotherapy Dosage Risk Assessment skin neoplasms Skin Neoplasms - mortality Skin Neoplasms - pathology Skin Neoplasms - therapy squamous cell Survival Analysis Treatment Outcome |
| title | Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin |
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