Joint Toxicity of Arsenic, Copper and Glyphosate on Behavior, Reproduction and Heat Shock Protein Response in Caenorhabditis elegans
The soil nematode Caenorhabditis elegans was used in 24-h acute exposures to arsenic (As), copper (Cu) and glyphosate (GPS) and to mixtures of As/Cu and As/GPS to investigate the effects of mixture exposures in the worms. A synergistic type of interaction was observed for acute toxicity with the As/...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 2017-04, Vol.98 (4), p.465-471 |
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| creator | Wang, Yunbiao Ezemaduka, Anastasia N. Li, Zhuheng Chen, Zhanyan Song, Chuantao |
| description | The soil nematode
Caenorhabditis elegans
was used in 24-h acute exposures to arsenic (As), copper (Cu) and glyphosate (GPS) and to mixtures of As/Cu and As/GPS to investigate the effects of mixture exposures in the worms. A synergistic type of interaction was observed for acute toxicity with the As/Cu and As/GPS mixtures. Sublethal 24-h exposures of 1/1000, 1/100 and 1/10 of the LC50 concentrations for As, Cu and GPS individually and for As/Cu and As/GPS mixtures were conducted to observe responses in locomotory behavior (head thrashing), reproduction, and heat shock protein expression. Head thrash frequency and reproduction exhibited concentration dependent decreases in both individual and combined exposures to the tested chemical stressors, and showed synergistic interactions even at micromolar concentrations. Furthermore, the HSP70 protein level was significantly increased following exposure to individual and combined chemical stressors in wild-type
C. elegans
. Our findings establish for the first time the effects of exposure to As/GPS and As/Cu mixtures in
C. elegans
. |
| doi_str_mv | 10.1007/s00128-017-2042-5 |
| format | Article |
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Caenorhabditis elegans
was used in 24-h acute exposures to arsenic (As), copper (Cu) and glyphosate (GPS) and to mixtures of As/Cu and As/GPS to investigate the effects of mixture exposures in the worms. A synergistic type of interaction was observed for acute toxicity with the As/Cu and As/GPS mixtures. Sublethal 24-h exposures of 1/1000, 1/100 and 1/10 of the LC50 concentrations for As, Cu and GPS individually and for As/Cu and As/GPS mixtures were conducted to observe responses in locomotory behavior (head thrashing), reproduction, and heat shock protein expression. Head thrash frequency and reproduction exhibited concentration dependent decreases in both individual and combined exposures to the tested chemical stressors, and showed synergistic interactions even at micromolar concentrations. Furthermore, the HSP70 protein level was significantly increased following exposure to individual and combined chemical stressors in wild-type
C. elegans
. Our findings establish for the first time the effects of exposure to As/GPS and As/Cu mixtures in
C. elegans
.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s00128-017-2042-5</identifier><identifier>PMID: 28224177</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acute toxicity ; Animal behavior ; Animals ; Aquatic Pollution ; Arsenic ; Arsenic - toxicity ; Biomarkers ; Caenorhabditis elegans ; Caenorhabditis elegans - drug effects ; Copper ; Copper - toxicity ; Drug Synergism ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Exposure ; Glycine - analogs & derivatives ; Glycine - toxicity ; Glyphosate ; Heat-Shock Proteins - biosynthesis ; Nematoda ; Nematodes ; Pollution ; Reproduction - drug effects ; Soil Science & Conservation ; Toxicology ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Bulletin of environmental contamination and toxicology, 2017-04, Vol.98 (4), p.465-471</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Bulletin of Environmental Contamination and Toxicology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-410d7368fd21f314df891962ca69f513556ae14ea384f17877d6772ab29c2db43</citedby><cites>FETCH-LOGICAL-c405t-410d7368fd21f314df891962ca69f513556ae14ea384f17877d6772ab29c2db43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00128-017-2042-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00128-017-2042-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28224177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yunbiao</creatorcontrib><creatorcontrib>Ezemaduka, Anastasia N.</creatorcontrib><creatorcontrib>Li, Zhuheng</creatorcontrib><creatorcontrib>Chen, Zhanyan</creatorcontrib><creatorcontrib>Song, Chuantao</creatorcontrib><title>Joint Toxicity of Arsenic, Copper and Glyphosate on Behavior, Reproduction and Heat Shock Protein Response in Caenorhabditis elegans</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><addtitle>Bull Environ Contam Toxicol</addtitle><description>The soil nematode
Caenorhabditis elegans
was used in 24-h acute exposures to arsenic (As), copper (Cu) and glyphosate (GPS) and to mixtures of As/Cu and As/GPS to investigate the effects of mixture exposures in the worms. A synergistic type of interaction was observed for acute toxicity with the As/Cu and As/GPS mixtures. Sublethal 24-h exposures of 1/1000, 1/100 and 1/10 of the LC50 concentrations for As, Cu and GPS individually and for As/Cu and As/GPS mixtures were conducted to observe responses in locomotory behavior (head thrashing), reproduction, and heat shock protein expression. Head thrash frequency and reproduction exhibited concentration dependent decreases in both individual and combined exposures to the tested chemical stressors, and showed synergistic interactions even at micromolar concentrations. Furthermore, the HSP70 protein level was significantly increased following exposure to individual and combined chemical stressors in wild-type
C. elegans
. Our findings establish for the first time the effects of exposure to As/GPS and As/Cu mixtures in
C. elegans
.</description><subject>Acute toxicity</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Arsenic</subject><subject>Arsenic - toxicity</subject><subject>Biomarkers</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - drug effects</subject><subject>Copper</subject><subject>Copper - toxicity</subject><subject>Drug Synergism</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Exposure</subject><subject>Glycine - analogs & derivatives</subject><subject>Glycine - toxicity</subject><subject>Glyphosate</subject><subject>Heat-Shock Proteins - biosynthesis</subject><subject>Nematoda</subject><subject>Nematodes</subject><subject>Pollution</subject><subject>Reproduction - drug effects</subject><subject>Soil Science & Conservation</subject><subject>Toxicology</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp10UFvFCEUB3BiNHatfgAvhsRLD53KY5iBPdaNtjZNNFrPhIU3XeosjMA07t0PLputxph4egR-7_GSPyEvgZ0BY_JNZgy4ahjIhjPBm-4RWYBoecMUY4_JglXUCNXDEXmW813VneL8KTnitQiQckF-XkUfCr2JP7z1ZUfjQM9TxuDtKV3FacJETXD0YtxNm5hNQRoDfYsbc-9jOqWfcUrRzbb4er2Hl2gK_bKJ9hv9lGJBH6rJUwwZaT2vDIaYNmbtfPGZ4oi3JuTn5MlgxowvHuox-fr-3c3qsrn-ePFhdX7dWMG60ghgTra9GhyHoQXhBrWEZc-t6ZdDB23X9QZBoGmVGEAqKV0vJTdrvrTcrUV7TE4Oc-vS32fMRW99tjiOJmCcswalQHYg-r7S1__QuzinULerSvYgQLC2Kjgom2LOCQc9Jb81aaeB6X1E-hCRrhHpfUS6qz2vHibP6y26Px2_M6mAH0CuT-EW019f_3fqL74_m0w</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Wang, Yunbiao</creator><creator>Ezemaduka, Anastasia N.</creator><creator>Li, Zhuheng</creator><creator>Chen, Zhanyan</creator><creator>Song, Chuantao</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TK</scope><scope>7TV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope></search><sort><creationdate>20170401</creationdate><title>Joint Toxicity of Arsenic, Copper and Glyphosate on Behavior, Reproduction and Heat Shock Protein Response in Caenorhabditis elegans</title><author>Wang, Yunbiao ; Ezemaduka, Anastasia N. ; Li, Zhuheng ; Chen, Zhanyan ; Song, Chuantao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-410d7368fd21f314df891962ca69f513556ae14ea384f17877d6772ab29c2db43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute toxicity</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Aquatic Pollution</topic><topic>Arsenic</topic><topic>Arsenic - 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Caenorhabditis elegans
was used in 24-h acute exposures to arsenic (As), copper (Cu) and glyphosate (GPS) and to mixtures of As/Cu and As/GPS to investigate the effects of mixture exposures in the worms. A synergistic type of interaction was observed for acute toxicity with the As/Cu and As/GPS mixtures. Sublethal 24-h exposures of 1/1000, 1/100 and 1/10 of the LC50 concentrations for As, Cu and GPS individually and for As/Cu and As/GPS mixtures were conducted to observe responses in locomotory behavior (head thrashing), reproduction, and heat shock protein expression. Head thrash frequency and reproduction exhibited concentration dependent decreases in both individual and combined exposures to the tested chemical stressors, and showed synergistic interactions even at micromolar concentrations. Furthermore, the HSP70 protein level was significantly increased following exposure to individual and combined chemical stressors in wild-type
C. elegans
. Our findings establish for the first time the effects of exposure to As/GPS and As/Cu mixtures in
C. elegans
.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28224177</pmid><doi>10.1007/s00128-017-2042-5</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0007-4861 |
| ispartof | Bulletin of environmental contamination and toxicology, 2017-04, Vol.98 (4), p.465-471 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Acute toxicity Animal behavior Animals Aquatic Pollution Arsenic Arsenic - toxicity Biomarkers Caenorhabditis elegans Caenorhabditis elegans - drug effects Copper Copper - toxicity Drug Synergism Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Exposure Glycine - analogs & derivatives Glycine - toxicity Glyphosate Heat-Shock Proteins - biosynthesis Nematoda Nematodes Pollution Reproduction - drug effects Soil Science & Conservation Toxicology Waste Water Technology Water Management Water Pollution Control |
| title | Joint Toxicity of Arsenic, Copper and Glyphosate on Behavior, Reproduction and Heat Shock Protein Response in Caenorhabditis elegans |
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