Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP‐43 subcellular distribution

Aims Cytoplasmic accumulation of the nuclear protein transactive response DNA‐binding protein 43 (TDP‐43) is an early determinant of motor neuron degeneration in most amyotrophic lateral sclerosis (ALS) cases. We previously disclosed this accumulation in circulating lymphomonocytes (CLM) of ALS pati...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropathology and applied neurobiology 2017-02, Vol.43 (2), p.133-153
Hauptverfasser:	De Marco, G., Lomartire, A., Calvo, A., Risso, A., De Luca, E., Mostert, M., Mandrioli, J., Caponnetto, C., Borghero, G., Manera, U., Canosa, A., Moglia, C., Restagno, G., Fini, N., Tarella, C., Giordana, M. T., Rinaudo, M. T., Chiò, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female gene mutations Humans Male Middle Aged monocytes Monocytes - metabolism Mutation transactive response DNA‐binding protein 43 subcellular localization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!