Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration
Studies have shown that oxidative stress is involved in the pathophysiology of bipolar disorder (BD). It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced...
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| Veröffentlicht in: | Metabolic brain disease 2017-04, Vol.32 (2), p.519-528 |
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| creator | Gomes, Lara M. Carvalho-Silva, Milena Teixeira, Letícia J. Rebelo, Joyce Mota, Isabella T. Bilesimo, Rafaela Michels, Monique Arent, Camila O. Mariot, Edemilson Dal-Pizzol, Felipe Scaini, Giselli Quevedo, João Streck, Emilio L. |
| description | Studies have shown that oxidative stress is involved in the pathophysiology of bipolar disorder (BD). It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced hyperactivity, a symptom similar to manic BD. Our results showed that the administration of fenproporex, in the prevent treatment protocol, increased lipid peroxidation in the prefrontal cortex (143%), hippocampus (58%) and striatum (181%), and ω3 fatty acids alone prevented this change in the prefrontal cortex and hippocampus, whereas the co-administration of ω3 fatty acids with VPA prevented the lipoperoxidation in all analyzed brain areas, and the co-administration of ω3 fatty acids with Li prevented this increase only in the prefrontal cortex and striatum. Moreover, superoxide dismutase (SOD) activity was decreased in the striatum (54%) in the prevention treatment, and the administration of ω3 fatty acids alone or in combination with Li and VPA partially prevented this inhibition. On the other hand, in the reversal treatment protocol, the administration of fenproporex increased carbonyl content in the prefrontal cortex (25%), hippocampus (114%) and striatum (91%), and in prefrontal coxter the administration of ω3 fatty acids alone or in combination with Li and VPA reversed this change, whereas in the hippocampus and striatum only ω3 fatty acids alone or in combination with VPA reversed this effect. Additionally, the administration of fenproporex resulted in a marked increase of TBARS in the hippocampus and striatum, and ω3 fatty acids alone or in combination with Li and VPA reversed this change. Finally, fenproporex administration decreased SOD activity in the prefrontal cortex (85%), hippocampus (52%) and striatum (76%), and the ω3 fatty acids in combination with VPA reversed this change in the prefrontal cortex and striatum, while the co-administration of ω3 fatty acids with Li reversed this inhibition in the hippocampus and striatum. In conclusion, our results support other studies showing the importance of ω3 fatty acids in the brain and the potential for these fatty acids to aid in the treatment of BD. |
| doi_str_mv | 10.1007/s11011-016-9942-7 |
| format | Article |
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It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced hyperactivity, a symptom similar to manic BD. Our results showed that the administration of fenproporex, in the prevent treatment protocol, increased lipid peroxidation in the prefrontal cortex (143%), hippocampus (58%) and striatum (181%), and ω3 fatty acids alone prevented this change in the prefrontal cortex and hippocampus, whereas the co-administration of ω3 fatty acids with VPA prevented the lipoperoxidation in all analyzed brain areas, and the co-administration of ω3 fatty acids with Li prevented this increase only in the prefrontal cortex and striatum. Moreover, superoxide dismutase (SOD) activity was decreased in the striatum (54%) in the prevention treatment, and the administration of ω3 fatty acids alone or in combination with Li and VPA partially prevented this inhibition. On the other hand, in the reversal treatment protocol, the administration of fenproporex increased carbonyl content in the prefrontal cortex (25%), hippocampus (114%) and striatum (91%), and in prefrontal coxter the administration of ω3 fatty acids alone or in combination with Li and VPA reversed this change, whereas in the hippocampus and striatum only ω3 fatty acids alone or in combination with VPA reversed this effect. Additionally, the administration of fenproporex resulted in a marked increase of TBARS in the hippocampus and striatum, and ω3 fatty acids alone or in combination with Li and VPA reversed this change. Finally, fenproporex administration decreased SOD activity in the prefrontal cortex (85%), hippocampus (52%) and striatum (76%), and the ω3 fatty acids in combination with VPA reversed this change in the prefrontal cortex and striatum, while the co-administration of ω3 fatty acids with Li reversed this inhibition in the hippocampus and striatum. In conclusion, our results support other studies showing the importance of ω3 fatty acids in the brain and the potential for these fatty acids to aid in the treatment of BD.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/s11011-016-9942-7</identifier><identifier>PMID: 27987060</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Amphetamines - toxicity ; Animals ; Antimanic Agents - therapeutic use ; Appetite Depressants - toxicity ; Behavior, Animal - drug effects ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain Chemistry - drug effects ; Fatty Acids, Omega-3 - therapeutic use ; Hyperkinesis - chemically induced ; Hyperkinesis - metabolism ; Hyperkinesis - psychology ; Lipid Peroxidation - drug effects ; Lithium Carbonate - therapeutic use ; Male ; Metabolic Diseases ; Neurology ; Neurosciences ; Oncology ; Original Article ; Oxidative Stress - drug effects ; Protein Carbonylation - drug effects ; Rats ; Rats, Wistar ; Superoxide Dismutase - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism ; Valproic Acid - therapeutic use</subject><ispartof>Metabolic brain disease, 2017-04, Vol.32 (2), p.519-528</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Metabolic Brain Disease is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-7a0780e03e32f14c85fdb0440700741462d988dc0a7d54574be505e0ea6b6bc83</citedby><cites>FETCH-LOGICAL-c405t-7a0780e03e32f14c85fdb0440700741462d988dc0a7d54574be505e0ea6b6bc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11011-016-9942-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11011-016-9942-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27987060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomes, Lara M.</creatorcontrib><creatorcontrib>Carvalho-Silva, Milena</creatorcontrib><creatorcontrib>Teixeira, Letícia J.</creatorcontrib><creatorcontrib>Rebelo, Joyce</creatorcontrib><creatorcontrib>Mota, Isabella T.</creatorcontrib><creatorcontrib>Bilesimo, Rafaela</creatorcontrib><creatorcontrib>Michels, Monique</creatorcontrib><creatorcontrib>Arent, Camila O.</creatorcontrib><creatorcontrib>Mariot, Edemilson</creatorcontrib><creatorcontrib>Dal-Pizzol, Felipe</creatorcontrib><creatorcontrib>Scaini, Giselli</creatorcontrib><creatorcontrib>Quevedo, João</creatorcontrib><creatorcontrib>Streck, Emilio L.</creatorcontrib><title>Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><addtitle>Metab Brain Dis</addtitle><description>Studies have shown that oxidative stress is involved in the pathophysiology of bipolar disorder (BD). It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced hyperactivity, a symptom similar to manic BD. Our results showed that the administration of fenproporex, in the prevent treatment protocol, increased lipid peroxidation in the prefrontal cortex (143%), hippocampus (58%) and striatum (181%), and ω3 fatty acids alone prevented this change in the prefrontal cortex and hippocampus, whereas the co-administration of ω3 fatty acids with VPA prevented the lipoperoxidation in all analyzed brain areas, and the co-administration of ω3 fatty acids with Li prevented this increase only in the prefrontal cortex and striatum. Moreover, superoxide dismutase (SOD) activity was decreased in the striatum (54%) in the prevention treatment, and the administration of ω3 fatty acids alone or in combination with Li and VPA partially prevented this inhibition. On the other hand, in the reversal treatment protocol, the administration of fenproporex increased carbonyl content in the prefrontal cortex (25%), hippocampus (114%) and striatum (91%), and in prefrontal coxter the administration of ω3 fatty acids alone or in combination with Li and VPA reversed this change, whereas in the hippocampus and striatum only ω3 fatty acids alone or in combination with VPA reversed this effect. Additionally, the administration of fenproporex resulted in a marked increase of TBARS in the hippocampus and striatum, and ω3 fatty acids alone or in combination with Li and VPA reversed this change. Finally, fenproporex administration decreased SOD activity in the prefrontal cortex (85%), hippocampus (52%) and striatum (76%), and the ω3 fatty acids in combination with VPA reversed this change in the prefrontal cortex and striatum, while the co-administration of ω3 fatty acids with Li reversed this inhibition in the hippocampus and striatum. In conclusion, our results support other studies showing the importance of ω3 fatty acids in the brain and the potential for these fatty acids to aid in the treatment of BD.</description><subject>Amphetamines - toxicity</subject><subject>Animals</subject><subject>Antimanic Agents - therapeutic use</subject><subject>Appetite Depressants - toxicity</subject><subject>Behavior, Animal - drug effects</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Chemistry - drug effects</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Hyperkinesis - chemically induced</subject><subject>Hyperkinesis - metabolism</subject><subject>Hyperkinesis - psychology</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lithium Carbonate - therapeutic use</subject><subject>Male</subject><subject>Metabolic Diseases</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Oxidative Stress - drug effects</subject><subject>Protein Carbonylation - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Valproic Acid - therapeutic use</subject><issn>0885-7490</issn><issn>1573-7365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU9rFTEUxYMo9tn2A7iRgBs3sTcz-TdLKdUKhW7qOmQmd2oeM5NnkiltP4Mf2jxfFREEV4Gb3zk3OYeQ1xzecwB9ljkHzhlwxbpONEw_Ixsudct0q-RzsgFjJNOigyPyKuctALSSdy_JUaM7o0HBhny_nvHWsZaOrpQH6obgM3WLp3OMnubi-jCFR0x1OBVMtMev7i7E5KafVLwP3pVwhxVNmDPdueRmLHtBWCoSZjdlmtd-i0NBT0ukIy67FHcx4T11fg5LqNpqEpcT8mKsOJ4-ncfky8eLm_NLdnX96fP5hys2CJCFaQfaAEKLbTNyMRg5-h6EAF1DEVyoxnfG-AGc9lJILXqUIBHQqV71g2mPybuDb33HtxVzsXPIA06TWzCu2XJjeI2tE_AfqGxUB1I1FX37F7qNa1rqRyqlFRdNq7pK8QM1pJhzwtHuUg0pPVgOdt-qPbRqa6t236rVVfPmyXntZ_S_Fb9qrEBzAHK9Wm4x_bH6n64_AEv3rjg</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Gomes, Lara M.</creator><creator>Carvalho-Silva, Milena</creator><creator>Teixeira, Letícia J.</creator><creator>Rebelo, Joyce</creator><creator>Mota, Isabella T.</creator><creator>Bilesimo, Rafaela</creator><creator>Michels, Monique</creator><creator>Arent, Camila O.</creator><creator>Mariot, Edemilson</creator><creator>Dal-Pizzol, Felipe</creator><creator>Scaini, Giselli</creator><creator>Quevedo, João</creator><creator>Streck, Emilio L.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration</title><author>Gomes, Lara M. ; Carvalho-Silva, Milena ; Teixeira, Letícia J. ; Rebelo, Joyce ; Mota, Isabella T. ; Bilesimo, Rafaela ; Michels, Monique ; Arent, Camila O. ; Mariot, Edemilson ; Dal-Pizzol, Felipe ; Scaini, Giselli ; Quevedo, João ; Streck, Emilio L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-7a0780e03e32f14c85fdb0440700741462d988dc0a7d54574be505e0ea6b6bc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amphetamines - toxicity</topic><topic>Animals</topic><topic>Antimanic Agents - therapeutic use</topic><topic>Appetite Depressants - toxicity</topic><topic>Behavior, Animal - drug effects</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Chemistry - drug effects</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Hyperkinesis - chemically induced</topic><topic>Hyperkinesis - metabolism</topic><topic>Hyperkinesis - psychology</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lithium Carbonate - therapeutic use</topic><topic>Male</topic><topic>Metabolic Diseases</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Oxidative Stress - drug effects</topic><topic>Protein Carbonylation - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Valproic Acid - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomes, Lara M.</creatorcontrib><creatorcontrib>Carvalho-Silva, Milena</creatorcontrib><creatorcontrib>Teixeira, Letícia J.</creatorcontrib><creatorcontrib>Rebelo, Joyce</creatorcontrib><creatorcontrib>Mota, Isabella T.</creatorcontrib><creatorcontrib>Bilesimo, Rafaela</creatorcontrib><creatorcontrib>Michels, Monique</creatorcontrib><creatorcontrib>Arent, Camila O.</creatorcontrib><creatorcontrib>Mariot, Edemilson</creatorcontrib><creatorcontrib>Dal-Pizzol, Felipe</creatorcontrib><creatorcontrib>Scaini, Giselli</creatorcontrib><creatorcontrib>Quevedo, João</creatorcontrib><creatorcontrib>Streck, Emilio L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolic brain disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomes, Lara M.</au><au>Carvalho-Silva, Milena</au><au>Teixeira, Letícia J.</au><au>Rebelo, Joyce</au><au>Mota, Isabella T.</au><au>Bilesimo, Rafaela</au><au>Michels, Monique</au><au>Arent, Camila O.</au><au>Mariot, Edemilson</au><au>Dal-Pizzol, Felipe</au><au>Scaini, Giselli</au><au>Quevedo, João</au><au>Streck, Emilio L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration</atitle><jtitle>Metabolic brain disease</jtitle><stitle>Metab Brain Dis</stitle><addtitle>Metab Brain Dis</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>32</volume><issue>2</issue><spage>519</spage><epage>528</epage><pages>519-528</pages><issn>0885-7490</issn><eissn>1573-7365</eissn><abstract>Studies have shown that oxidative stress is involved in the pathophysiology of bipolar disorder (BD). It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced hyperactivity, a symptom similar to manic BD. Our results showed that the administration of fenproporex, in the prevent treatment protocol, increased lipid peroxidation in the prefrontal cortex (143%), hippocampus (58%) and striatum (181%), and ω3 fatty acids alone prevented this change in the prefrontal cortex and hippocampus, whereas the co-administration of ω3 fatty acids with VPA prevented the lipoperoxidation in all analyzed brain areas, and the co-administration of ω3 fatty acids with Li prevented this increase only in the prefrontal cortex and striatum. Moreover, superoxide dismutase (SOD) activity was decreased in the striatum (54%) in the prevention treatment, and the administration of ω3 fatty acids alone or in combination with Li and VPA partially prevented this inhibition. On the other hand, in the reversal treatment protocol, the administration of fenproporex increased carbonyl content in the prefrontal cortex (25%), hippocampus (114%) and striatum (91%), and in prefrontal coxter the administration of ω3 fatty acids alone or in combination with Li and VPA reversed this change, whereas in the hippocampus and striatum only ω3 fatty acids alone or in combination with VPA reversed this effect. Additionally, the administration of fenproporex resulted in a marked increase of TBARS in the hippocampus and striatum, and ω3 fatty acids alone or in combination with Li and VPA reversed this change. Finally, fenproporex administration decreased SOD activity in the prefrontal cortex (85%), hippocampus (52%) and striatum (76%), and the ω3 fatty acids in combination with VPA reversed this change in the prefrontal cortex and striatum, while the co-administration of ω3 fatty acids with Li reversed this inhibition in the hippocampus and striatum. In conclusion, our results support other studies showing the importance of ω3 fatty acids in the brain and the potential for these fatty acids to aid in the treatment of BD.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27987060</pmid><doi>10.1007/s11011-016-9942-7</doi><tpages>10</tpages></addata></record> |
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| subjects | Amphetamines - toxicity Animals Antimanic Agents - therapeutic use Appetite Depressants - toxicity Behavior, Animal - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Brain Chemistry - drug effects Fatty Acids, Omega-3 - therapeutic use Hyperkinesis - chemically induced Hyperkinesis - metabolism Hyperkinesis - psychology Lipid Peroxidation - drug effects Lithium Carbonate - therapeutic use Male Metabolic Diseases Neurology Neurosciences Oncology Original Article Oxidative Stress - drug effects Protein Carbonylation - drug effects Rats Rats, Wistar Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism Valproic Acid - therapeutic use |
| title | Omega-3 fatty acids and mood stabilizers alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration |
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