Effect of amoxicillin exposure on brain, gill, liver, and kidney of common carp (Cyprinus carpio): The role of amoxicilloic acid
ABSTRACT Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world due to its broad‐spectrum activity against different bacterial strains as well as its use as a growth promoter in animal husbandry. Although residues of this antibacterial agent have been found in water bo...
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| Veröffentlicht in: | Environmental toxicology 2017-04, Vol.32 (4), p.1102-1120 |
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| creator | Elizalde‐Velázquez, Armando Martínez‐Rodríguez, Héctor Galar‐Martínez, Marcela Dublán‐García, Octavio Islas‐Flores, Hariz Rodríguez‐Flores, Juana Castañeda‐Peñalvo, Gregorio Lizcano‐Sanz, Isabel Gómez‐Oliván, Leobardo Manuel |
| description | ABSTRACT
Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world due to its broad‐spectrum activity against different bacterial strains as well as its use as a growth promoter in animal husbandry. Although residues of this antibacterial agent have been found in water bodies in diverse countries, there is not enough information on its potential toxicity to aquatic organisms such as the common carp Cyprinus carpio. This study aimed to evaluate AMX‐induced oxidative stress in brain, gill, liver and kidney of C. carpio. Carp were exposed to three different concentrations of AMX (10 ng/L, 10 μg/L, 10 mg/L) for 12, 24, 48, 72, and 96 h, and the following biomarkers were evaluated: lipid peroxidation (LPX), hydroperoxide content (HPC), protein carbonyl content (PCC) and activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Amoxicillin and its main degradation product amoxicilloic acid (AMA) were determined by high performance liquid chromatography coupled with electrochemical detection and UV detection (HPLC‐EC‐UV). Significant increases in LPX, HPC, and PCC (P < 0.05) were found in all study organs, particularly kidney, as well as significant changes in antioxidant enzymes activity. Amoxicilloic acid in water is concluded to induce oxidative stress in C. carpio, this damage being highest in kidney. The biomarkers used are effective for the assessment of the environmental impact of this agent on aquatic species. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1102–1120, 2017. |
| doi_str_mv | 10.1002/tox.22307 |
| format | Article |
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Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world due to its broad‐spectrum activity against different bacterial strains as well as its use as a growth promoter in animal husbandry. Although residues of this antibacterial agent have been found in water bodies in diverse countries, there is not enough information on its potential toxicity to aquatic organisms such as the common carp Cyprinus carpio. This study aimed to evaluate AMX‐induced oxidative stress in brain, gill, liver and kidney of C. carpio. Carp were exposed to three different concentrations of AMX (10 ng/L, 10 μg/L, 10 mg/L) for 12, 24, 48, 72, and 96 h, and the following biomarkers were evaluated: lipid peroxidation (LPX), hydroperoxide content (HPC), protein carbonyl content (PCC) and activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Amoxicillin and its main degradation product amoxicilloic acid (AMA) were determined by high performance liquid chromatography coupled with electrochemical detection and UV detection (HPLC‐EC‐UV). Significant increases in LPX, HPC, and PCC (P < 0.05) were found in all study organs, particularly kidney, as well as significant changes in antioxidant enzymes activity. Amoxicilloic acid in water is concluded to induce oxidative stress in C. carpio, this damage being highest in kidney. The biomarkers used are effective for the assessment of the environmental impact of this agent on aquatic species. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1102–1120, 2017.</description><identifier>ISSN: 1520-4081</identifier><identifier>EISSN: 1522-7278</identifier><identifier>DOI: 10.1002/tox.22307</identifier><identifier>PMID: 27403921</identifier><identifier>CODEN: ETOXFH</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>amoxicillin ; Amoxicillin - analogs & derivatives ; Amoxicillin - analysis ; Amoxicillin - metabolism ; Amoxicillin - pharmacokinetics ; Amoxicillin - toxicity ; amoxicilloic acid ; Animals ; Antioxidants - metabolism ; Biomarkers - metabolism ; Brain - drug effects ; Brain - metabolism ; Carps - metabolism ; Catalase - metabolism ; Cyprinus carpio ; Gills - drug effects ; Gills - metabolism ; Glutathione Peroxidase - metabolism ; HPLC‐EC‐UV ; Hydrogen Peroxide - metabolism ; Kidney - drug effects ; Kidney - metabolism ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Liver - metabolism ; Organ Specificity ; Oxidation-Reduction ; oxidative stress ; Oxidative Stress - drug effects ; Protein Carbonylation - drug effects ; Superoxide Dismutase - metabolism ; Water Pollutants, Chemical - analysis ; Water Pollutants, Chemical - pharmacokinetics ; Water Pollutants, Chemical - toxicity</subject><ispartof>Environmental toxicology, 2017-04, Vol.32 (4), p.1102-1120</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4237-9cf037ac57dcf5fc64d1d08315c942bd881ce13d2b814ecb0e8560a4dab7822c3</citedby><cites>FETCH-LOGICAL-c4237-9cf037ac57dcf5fc64d1d08315c942bd881ce13d2b814ecb0e8560a4dab7822c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftox.22307$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftox.22307$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27403921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elizalde‐Velázquez, Armando</creatorcontrib><creatorcontrib>Martínez‐Rodríguez, Héctor</creatorcontrib><creatorcontrib>Galar‐Martínez, Marcela</creatorcontrib><creatorcontrib>Dublán‐García, Octavio</creatorcontrib><creatorcontrib>Islas‐Flores, Hariz</creatorcontrib><creatorcontrib>Rodríguez‐Flores, Juana</creatorcontrib><creatorcontrib>Castañeda‐Peñalvo, Gregorio</creatorcontrib><creatorcontrib>Lizcano‐Sanz, Isabel</creatorcontrib><creatorcontrib>Gómez‐Oliván, Leobardo Manuel</creatorcontrib><title>Effect of amoxicillin exposure on brain, gill, liver, and kidney of common carp (Cyprinus carpio): The role of amoxicilloic acid</title><title>Environmental toxicology</title><addtitle>Environ Toxicol</addtitle><description>ABSTRACT
Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world due to its broad‐spectrum activity against different bacterial strains as well as its use as a growth promoter in animal husbandry. Although residues of this antibacterial agent have been found in water bodies in diverse countries, there is not enough information on its potential toxicity to aquatic organisms such as the common carp Cyprinus carpio. This study aimed to evaluate AMX‐induced oxidative stress in brain, gill, liver and kidney of C. carpio. Carp were exposed to three different concentrations of AMX (10 ng/L, 10 μg/L, 10 mg/L) for 12, 24, 48, 72, and 96 h, and the following biomarkers were evaluated: lipid peroxidation (LPX), hydroperoxide content (HPC), protein carbonyl content (PCC) and activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Amoxicillin and its main degradation product amoxicilloic acid (AMA) were determined by high performance liquid chromatography coupled with electrochemical detection and UV detection (HPLC‐EC‐UV). Significant increases in LPX, HPC, and PCC (P < 0.05) were found in all study organs, particularly kidney, as well as significant changes in antioxidant enzymes activity. Amoxicilloic acid in water is concluded to induce oxidative stress in C. carpio, this damage being highest in kidney. The biomarkers used are effective for the assessment of the environmental impact of this agent on aquatic species. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1102–1120, 2017.</description><subject>amoxicillin</subject><subject>Amoxicillin - analogs & derivatives</subject><subject>Amoxicillin - analysis</subject><subject>Amoxicillin - metabolism</subject><subject>Amoxicillin - pharmacokinetics</subject><subject>Amoxicillin - toxicity</subject><subject>amoxicilloic acid</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Carps - metabolism</subject><subject>Catalase - metabolism</subject><subject>Cyprinus carpio</subject><subject>Gills - drug effects</subject><subject>Gills - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>HPLC‐EC‐UV</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Organ Specificity</subject><subject>Oxidation-Reduction</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Protein Carbonylation - drug effects</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollutants, Chemical - pharmacokinetics</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>1520-4081</issn><issn>1522-7278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1rGzEQhkVoaVK3h_yBIOglAW-ir13JuRWTLwjk4kBvi3Y02yrdXbmSt7Vv_elV7CSQQk6S0KNnNPMScsjZKWdMnK3C-lQIyfQeOeClEIUW2rzb7lmhmOH75GNKD4yxWVVWH8i-0IrJmeAH5O9F2yKsaGip7cPag-86P1BcL0MaI9Iw0CZaP0zp93wzpZ3_jXFK7eDoT-8G3Dy-hND3GQQbl_R4vllGP4xpe_Th5JwufiCNocNXRYIHasG7T-R9a7uEn5_WCbm_vFjMr4vbu6ub-dfbApSQuphBy6S2UGoHbdlCpRx3zEhewkyJxhnDAbl0ojFcITQMTVkxq5xttBEC5IQc77zLGH6NmFZ17xNg19kBw5hqng1aGSlMRr_8hz6EMQ75d5nSFZNK5WlPyMmOghhSitjWue_exk3NWf0YS51jqbexZPboyTg2PboX8jmHDJztgD--w83bpnpx922n_Ad0yZa8</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Elizalde‐Velázquez, Armando</creator><creator>Martínez‐Rodríguez, Héctor</creator><creator>Galar‐Martínez, Marcela</creator><creator>Dublán‐García, Octavio</creator><creator>Islas‐Flores, Hariz</creator><creator>Rodríguez‐Flores, Juana</creator><creator>Castañeda‐Peñalvo, Gregorio</creator><creator>Lizcano‐Sanz, Isabel</creator><creator>Gómez‐Oliván, Leobardo Manuel</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>SOI</scope></search><sort><creationdate>201704</creationdate><title>Effect of amoxicillin exposure on brain, gill, liver, and kidney of common carp (Cyprinus carpio): The role of amoxicilloic acid</title><author>Elizalde‐Velázquez, Armando ; Martínez‐Rodríguez, Héctor ; Galar‐Martínez, Marcela ; Dublán‐García, Octavio ; Islas‐Flores, Hariz ; Rodríguez‐Flores, Juana ; Castañeda‐Peñalvo, Gregorio ; Lizcano‐Sanz, Isabel ; Gómez‐Oliván, Leobardo Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4237-9cf037ac57dcf5fc64d1d08315c942bd881ce13d2b814ecb0e8560a4dab7822c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>amoxicillin</topic><topic>Amoxicillin - analogs & derivatives</topic><topic>Amoxicillin - analysis</topic><topic>Amoxicillin - metabolism</topic><topic>Amoxicillin - pharmacokinetics</topic><topic>Amoxicillin - toxicity</topic><topic>amoxicilloic acid</topic><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Carps - metabolism</topic><topic>Catalase - metabolism</topic><topic>Cyprinus carpio</topic><topic>Gills - drug effects</topic><topic>Gills - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>HPLC‐EC‐UV</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Organ Specificity</topic><topic>Oxidation-Reduction</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Protein Carbonylation - drug effects</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollutants, Chemical - pharmacokinetics</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elizalde‐Velázquez, Armando</creatorcontrib><creatorcontrib>Martínez‐Rodríguez, Héctor</creatorcontrib><creatorcontrib>Galar‐Martínez, Marcela</creatorcontrib><creatorcontrib>Dublán‐García, Octavio</creatorcontrib><creatorcontrib>Islas‐Flores, Hariz</creatorcontrib><creatorcontrib>Rodríguez‐Flores, Juana</creatorcontrib><creatorcontrib>Castañeda‐Peñalvo, Gregorio</creatorcontrib><creatorcontrib>Lizcano‐Sanz, Isabel</creatorcontrib><creatorcontrib>Gómez‐Oliván, Leobardo Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elizalde‐Velázquez, Armando</au><au>Martínez‐Rodríguez, Héctor</au><au>Galar‐Martínez, Marcela</au><au>Dublán‐García, Octavio</au><au>Islas‐Flores, Hariz</au><au>Rodríguez‐Flores, Juana</au><au>Castañeda‐Peñalvo, Gregorio</au><au>Lizcano‐Sanz, Isabel</au><au>Gómez‐Oliván, Leobardo Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of amoxicillin exposure on brain, gill, liver, and kidney of common carp (Cyprinus carpio): The role of amoxicilloic acid</atitle><jtitle>Environmental toxicology</jtitle><addtitle>Environ Toxicol</addtitle><date>2017-04</date><risdate>2017</risdate><volume>32</volume><issue>4</issue><spage>1102</spage><epage>1120</epage><pages>1102-1120</pages><issn>1520-4081</issn><eissn>1522-7278</eissn><coden>ETOXFH</coden><abstract>ABSTRACT
Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world due to its broad‐spectrum activity against different bacterial strains as well as its use as a growth promoter in animal husbandry. Although residues of this antibacterial agent have been found in water bodies in diverse countries, there is not enough information on its potential toxicity to aquatic organisms such as the common carp Cyprinus carpio. This study aimed to evaluate AMX‐induced oxidative stress in brain, gill, liver and kidney of C. carpio. Carp were exposed to three different concentrations of AMX (10 ng/L, 10 μg/L, 10 mg/L) for 12, 24, 48, 72, and 96 h, and the following biomarkers were evaluated: lipid peroxidation (LPX), hydroperoxide content (HPC), protein carbonyl content (PCC) and activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Amoxicillin and its main degradation product amoxicilloic acid (AMA) were determined by high performance liquid chromatography coupled with electrochemical detection and UV detection (HPLC‐EC‐UV). Significant increases in LPX, HPC, and PCC (P < 0.05) were found in all study organs, particularly kidney, as well as significant changes in antioxidant enzymes activity. Amoxicilloic acid in water is concluded to induce oxidative stress in C. carpio, this damage being highest in kidney. The biomarkers used are effective for the assessment of the environmental impact of this agent on aquatic species. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1102–1120, 2017.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27403921</pmid><doi>10.1002/tox.22307</doi><tpages>19</tpages></addata></record> |
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| subjects | amoxicillin Amoxicillin - analogs & derivatives Amoxicillin - analysis Amoxicillin - metabolism Amoxicillin - pharmacokinetics Amoxicillin - toxicity amoxicilloic acid Animals Antioxidants - metabolism Biomarkers - metabolism Brain - drug effects Brain - metabolism Carps - metabolism Catalase - metabolism Cyprinus carpio Gills - drug effects Gills - metabolism Glutathione Peroxidase - metabolism HPLC‐EC‐UV Hydrogen Peroxide - metabolism Kidney - drug effects Kidney - metabolism Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Organ Specificity Oxidation-Reduction oxidative stress Oxidative Stress - drug effects Protein Carbonylation - drug effects Superoxide Dismutase - metabolism Water Pollutants, Chemical - analysis Water Pollutants, Chemical - pharmacokinetics Water Pollutants, Chemical - toxicity |
| title | Effect of amoxicillin exposure on brain, gill, liver, and kidney of common carp (Cyprinus carpio): The role of amoxicilloic acid |
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