The Role of Yeast DNA 3′-Phosphatase Tpp1 and Rad1/Rad10 Endonuclease in Processing Spontaneous and Induced Base Lesions

Tpp1 is a DNA 3′-phosphatase in Saccharomyces cerevisiae that is believed to act during strand break repair. It is homologous to one domain of mammalian polynucleotide kinase/3′-phosphatase. Unlike in yeast, we found that Tpp1 could confer resistance to methylmethane sulfonate when expressed in bact...

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Veröffentlicht in:	The Journal of biological chemistry 2003-08, Vol.278 (33), p.31434-31443
Hauptverfasser:	Karumbati, Anandi S., Deshpande, Rajashree A., Jilani, Arshad, Vance, John R., Ramotar, Dindial, Wilson, Thomas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - metabolism Aspartic Acid - genetics Deoxyribonuclease (Pyrimidine Dimer) DNA Damage - physiology DNA Repair - physiology DNA Repair Enzymes DNA-Binding Proteins DNA-Formamidopyrimidine Glycosylase Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Endonucleases - metabolism Escherichia coli Proteins Fungal Proteins - metabolism Hydrogen Peroxide - pharmacology Methyl Methanesulfonate - pharmacology Mutagens - pharmacology Mutation N-Glycosyl Hydrolases - genetics N-Glycosyl Hydrolases - metabolism Nucleotidases - metabolism Oxidants - pharmacology Phenotype Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae Proteins - metabolism Single-Strand Specific DNA and RNA Endonucleases
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