Prevention of latex allergy among health care workers: Evaluation of the extractable latex protein content in different types of medical gloves
Background Since the 1980s, there has been increased use of latex gloves by health care workers and a concomitant increase of irritant and allergic reactions. The total protein content and the latex allergenic protein content in different types of medical gloves commonly used in our hospital were ev...
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| Veröffentlicht in: | American journal of industrial medicine 2003-07, Vol.44 (1), p.24-31 |
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| creator | Crippa, Michela Belleri, Luca Mistrello, Gianni Carsana, Teresina Neri, Gloria Alessio, Lorenzo |
| description | Background
Since the 1980s, there has been increased use of latex gloves by health care workers and a concomitant increase of irritant and allergic reactions. The total protein content and the latex allergenic protein content in different types of medical gloves commonly used in our hospital were evaluated to acquire information useful for preventing latex allergy in our hospital personnel.
Methods
The total protein content and the allergic latex protein contents were evaluated with Lowry modified method and RAST inhibition assay in samples and extracts of 29 different types of medical gloves.
Results
The highest concentrations of total proteins and allergenic latex proteins were found in examination powdered latex gloves and in surgical powdered latex gloves; a significant amount of latex proteins was found in some brands of nitrile gloves.
Conclusions
The clear association between the total protein levels and the allergenic latex protein levels suggests that the gloves with highest total protein content have the greatest allergenic potential. Therefore, it is recommended that manufacturing companies should provide package inserts including the total protein contents and possibly allergenic latex protein levels. They should declare whether they have added latex to their nitrile glove formulation. RAST‐inhibition assays directly on glove samples instead of glove extract seems to be a good reliable and faster alternative for the evaluation of the allergenic potential of latex gloves. Am. J. Ind. Med. 44:24–31, 2003. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajim.10232 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_18815352</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18815352</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4242-46b8b4516601cf8bc54ba8c69a9b363ad132bd06b914c74e90b76b0e941a8f1d3</originalsourceid><addsrcrecordid>eNp9kEFv1DAQhSMEotvChR-AfIEDUsB2HMfhVlVlW2iBA1Bu1tiZ7Lp1ksXObru_gr-Ml03pjdOMpe-98XtZ9oLRt4xS_g6uXZc2XvBH2YzRusopr8TjbJYGy4tSyYPsMMZrShkTUjzNDhhXnLOCz7LfXwNusB_d0JOhJR5GvCPgPYbFlkA39AuyRPDjklgISG6HcIMhvienG_BruJeNSyR4NwawIxiPk80qDCO6ntihH9MJktbGtS2G3WPcrjDutB02zoInCz9sMD7LnrTgIz6f5lH2_cPpt5Oz_OLL_Pzk-CK3ggueC2mUESWTkjLbKmNLYUBZWUNtCllAk8KZhkpTM2ErgTU1lTQUa8FAtawpjrLXe9_0yV9rjKPuXLToPfQ4rKNmSrGyKHkC3-xBG4YYA7Z6FVwHYasZ1bv69a5-_bf-BL-cXNcm5XpAp74T8GoCIKbQbYDeuvjAiVoUVInEsT136zxu_3NSH388v7w_nu81Lqb2_2kg3GhZFVWprz7PtbqiP-by0099WfwBQueuaw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18815352</pqid></control><display><type>article</type><title>Prevention of latex allergy among health care workers: Evaluation of the extractable latex protein content in different types of medical gloves</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Crippa, Michela ; Belleri, Luca ; Mistrello, Gianni ; Carsana, Teresina ; Neri, Gloria ; Alessio, Lorenzo</creator><creatorcontrib>Crippa, Michela ; Belleri, Luca ; Mistrello, Gianni ; Carsana, Teresina ; Neri, Gloria ; Alessio, Lorenzo</creatorcontrib><description>Background
Since the 1980s, there has been increased use of latex gloves by health care workers and a concomitant increase of irritant and allergic reactions. The total protein content and the latex allergenic protein content in different types of medical gloves commonly used in our hospital were evaluated to acquire information useful for preventing latex allergy in our hospital personnel.
Methods
The total protein content and the allergic latex protein contents were evaluated with Lowry modified method and RAST inhibition assay in samples and extracts of 29 different types of medical gloves.
Results
The highest concentrations of total proteins and allergenic latex proteins were found in examination powdered latex gloves and in surgical powdered latex gloves; a significant amount of latex proteins was found in some brands of nitrile gloves.
Conclusions
The clear association between the total protein levels and the allergenic latex protein levels suggests that the gloves with highest total protein content have the greatest allergenic potential. Therefore, it is recommended that manufacturing companies should provide package inserts including the total protein contents and possibly allergenic latex protein levels. They should declare whether they have added latex to their nitrile glove formulation. RAST‐inhibition assays directly on glove samples instead of glove extract seems to be a good reliable and faster alternative for the evaluation of the allergenic potential of latex gloves. Am. J. Ind. Med. 44:24–31, 2003. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.10232</identifier><identifier>PMID: 12822132</identifier><identifier>CODEN: AJIMD8</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Allergens - analysis ; Allergic diseases ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Elastomers ; Gloves, Protective - adverse effects ; health care workers ; Humans ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Immunopathology ; Italy ; Latex - analysis ; latex allergy ; latex gloves ; Latex Hypersensitivity - immunology ; Latex Hypersensitivity - prevention & control ; Medical sciences ; Personnel, Hospital ; Polyvinyls - analysis ; Powders ; prevention ; Proteins - analysis ; Proteins - immunology ; Radioallergosorbent Test ; Rubber - analysis ; Skin allergic diseases. Stinging insect allergies ; Toxicology ; Various organic compounds</subject><ispartof>American journal of industrial medicine, 2003-07, Vol.44 (1), p.24-31</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4242-46b8b4516601cf8bc54ba8c69a9b363ad132bd06b914c74e90b76b0e941a8f1d3</citedby><cites>FETCH-LOGICAL-c4242-46b8b4516601cf8bc54ba8c69a9b363ad132bd06b914c74e90b76b0e941a8f1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajim.10232$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajim.10232$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14943084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12822132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crippa, Michela</creatorcontrib><creatorcontrib>Belleri, Luca</creatorcontrib><creatorcontrib>Mistrello, Gianni</creatorcontrib><creatorcontrib>Carsana, Teresina</creatorcontrib><creatorcontrib>Neri, Gloria</creatorcontrib><creatorcontrib>Alessio, Lorenzo</creatorcontrib><title>Prevention of latex allergy among health care workers: Evaluation of the extractable latex protein content in different types of medical gloves</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>Background
Since the 1980s, there has been increased use of latex gloves by health care workers and a concomitant increase of irritant and allergic reactions. The total protein content and the latex allergenic protein content in different types of medical gloves commonly used in our hospital were evaluated to acquire information useful for preventing latex allergy in our hospital personnel.
Methods
The total protein content and the allergic latex protein contents were evaluated with Lowry modified method and RAST inhibition assay in samples and extracts of 29 different types of medical gloves.
Results
The highest concentrations of total proteins and allergenic latex proteins were found in examination powdered latex gloves and in surgical powdered latex gloves; a significant amount of latex proteins was found in some brands of nitrile gloves.
Conclusions
The clear association between the total protein levels and the allergenic latex protein levels suggests that the gloves with highest total protein content have the greatest allergenic potential. Therefore, it is recommended that manufacturing companies should provide package inserts including the total protein contents and possibly allergenic latex protein levels. They should declare whether they have added latex to their nitrile glove formulation. RAST‐inhibition assays directly on glove samples instead of glove extract seems to be a good reliable and faster alternative for the evaluation of the allergenic potential of latex gloves. Am. J. Ind. Med. 44:24–31, 2003. © 2003 Wiley‐Liss, Inc.</description><subject>Allergens - analysis</subject><subject>Allergic diseases</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Elastomers</subject><subject>Gloves, Protective - adverse effects</subject><subject>health care workers</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunopathology</subject><subject>Italy</subject><subject>Latex - analysis</subject><subject>latex allergy</subject><subject>latex gloves</subject><subject>Latex Hypersensitivity - immunology</subject><subject>Latex Hypersensitivity - prevention & control</subject><subject>Medical sciences</subject><subject>Personnel, Hospital</subject><subject>Polyvinyls - analysis</subject><subject>Powders</subject><subject>prevention</subject><subject>Proteins - analysis</subject><subject>Proteins - immunology</subject><subject>Radioallergosorbent Test</subject><subject>Rubber - analysis</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFv1DAQhSMEotvChR-AfIEDUsB2HMfhVlVlW2iBA1Bu1tiZ7Lp1ksXObru_gr-Ml03pjdOMpe-98XtZ9oLRt4xS_g6uXZc2XvBH2YzRusopr8TjbJYGy4tSyYPsMMZrShkTUjzNDhhXnLOCz7LfXwNusB_d0JOhJR5GvCPgPYbFlkA39AuyRPDjklgISG6HcIMhvienG_BruJeNSyR4NwawIxiPk80qDCO6ntihH9MJktbGtS2G3WPcrjDutB02zoInCz9sMD7LnrTgIz6f5lH2_cPpt5Oz_OLL_Pzk-CK3ggueC2mUESWTkjLbKmNLYUBZWUNtCllAk8KZhkpTM2ErgTU1lTQUa8FAtawpjrLXe9_0yV9rjKPuXLToPfQ4rKNmSrGyKHkC3-xBG4YYA7Z6FVwHYasZ1bv69a5-_bf-BL-cXNcm5XpAp74T8GoCIKbQbYDeuvjAiVoUVInEsT136zxu_3NSH388v7w_nu81Lqb2_2kg3GhZFVWprz7PtbqiP-by0099WfwBQueuaw</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Crippa, Michela</creator><creator>Belleri, Luca</creator><creator>Mistrello, Gianni</creator><creator>Carsana, Teresina</creator><creator>Neri, Gloria</creator><creator>Alessio, Lorenzo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200307</creationdate><title>Prevention of latex allergy among health care workers: Evaluation of the extractable latex protein content in different types of medical gloves</title><author>Crippa, Michela ; Belleri, Luca ; Mistrello, Gianni ; Carsana, Teresina ; Neri, Gloria ; Alessio, Lorenzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4242-46b8b4516601cf8bc54ba8c69a9b363ad132bd06b914c74e90b76b0e941a8f1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Allergens - analysis</topic><topic>Allergic diseases</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Elastomers</topic><topic>Gloves, Protective - adverse effects</topic><topic>health care workers</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunopathology</topic><topic>Italy</topic><topic>Latex - analysis</topic><topic>latex allergy</topic><topic>latex gloves</topic><topic>Latex Hypersensitivity - immunology</topic><topic>Latex Hypersensitivity - prevention & control</topic><topic>Medical sciences</topic><topic>Personnel, Hospital</topic><topic>Polyvinyls - analysis</topic><topic>Powders</topic><topic>prevention</topic><topic>Proteins - analysis</topic><topic>Proteins - immunology</topic><topic>Radioallergosorbent Test</topic><topic>Rubber - analysis</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crippa, Michela</creatorcontrib><creatorcontrib>Belleri, Luca</creatorcontrib><creatorcontrib>Mistrello, Gianni</creatorcontrib><creatorcontrib>Carsana, Teresina</creatorcontrib><creatorcontrib>Neri, Gloria</creatorcontrib><creatorcontrib>Alessio, Lorenzo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crippa, Michela</au><au>Belleri, Luca</au><au>Mistrello, Gianni</au><au>Carsana, Teresina</au><au>Neri, Gloria</au><au>Alessio, Lorenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of latex allergy among health care workers: Evaluation of the extractable latex protein content in different types of medical gloves</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>2003-07</date><risdate>2003</risdate><volume>44</volume><issue>1</issue><spage>24</spage><epage>31</epage><pages>24-31</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><coden>AJIMD8</coden><abstract>Background
Since the 1980s, there has been increased use of latex gloves by health care workers and a concomitant increase of irritant and allergic reactions. The total protein content and the latex allergenic protein content in different types of medical gloves commonly used in our hospital were evaluated to acquire information useful for preventing latex allergy in our hospital personnel.
Methods
The total protein content and the allergic latex protein contents were evaluated with Lowry modified method and RAST inhibition assay in samples and extracts of 29 different types of medical gloves.
Results
The highest concentrations of total proteins and allergenic latex proteins were found in examination powdered latex gloves and in surgical powdered latex gloves; a significant amount of latex proteins was found in some brands of nitrile gloves.
Conclusions
The clear association between the total protein levels and the allergenic latex protein levels suggests that the gloves with highest total protein content have the greatest allergenic potential. Therefore, it is recommended that manufacturing companies should provide package inserts including the total protein contents and possibly allergenic latex protein levels. They should declare whether they have added latex to their nitrile glove formulation. RAST‐inhibition assays directly on glove samples instead of glove extract seems to be a good reliable and faster alternative for the evaluation of the allergenic potential of latex gloves. Am. J. Ind. Med. 44:24–31, 2003. © 2003 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12822132</pmid><doi>10.1002/ajim.10232</doi><tpages>8</tpages></addata></record> |
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| ispartof | American journal of industrial medicine, 2003-07, Vol.44 (1), p.24-31 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Allergens - analysis Allergic diseases Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Elastomers Gloves, Protective - adverse effects health care workers Humans Immunoglobulin E - blood Immunoglobulin E - immunology Immunopathology Italy Latex - analysis latex allergy latex gloves Latex Hypersensitivity - immunology Latex Hypersensitivity - prevention & control Medical sciences Personnel, Hospital Polyvinyls - analysis Powders prevention Proteins - analysis Proteins - immunology Radioallergosorbent Test Rubber - analysis Skin allergic diseases. Stinging insect allergies Toxicology Various organic compounds |
| title | Prevention of latex allergy among health care workers: Evaluation of the extractable latex protein content in different types of medical gloves |
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