Spatial molecular epidemiology of carbapenem‐resistant and New Delhi metallo beta‐lactamase (blaNDM)‐producing Escherichia coli in the piglets of organized farms in India
Aim A cross‐sectional study was conducted in 10 government‐organized pig farms between 2014 and 2016 representing seven states of India to understand the epidemiology of carbapenem resistance in the Escherichia coli. Methods and Results In this study, fecal sample (n = 673) from non‐diarrheic (n = 5...
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| Veröffentlicht in: | Journal of applied microbiology 2017-06, Vol.122 (6), p.1537-1546 |
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| creator | Pruthvishree, B.S. Vinodh Kumar, O.R. Sinha, D.K. Malik, Y.P.S. Dubal, Z.B. Desingu, P.A. Shivakumar, M. Krishnaswamy, N. Singh, B.R. |
| description | Aim
A cross‐sectional study was conducted in 10 government‐organized pig farms between 2014 and 2016 representing seven states of India to understand the epidemiology of carbapenem resistance in the Escherichia coli.
Methods and Results
In this study, fecal sample (n = 673) from non‐diarrheic (n = 501) and diarrheic (n = 172) piglets were processed for isolation of carbapenem resistant E. coli. Of 673, E. coli isolate (n = 112) was genotyped for confirming the carbapenem resistance and associated virulence factors. Of the 112 isolates, 23 were phenotypically resistant to carbapenem and 8 were carrying the New Delhi metallo beta‐lactamase (blaNDM) gene. The carbapenem‐resistant isolates also produced extended spectrum beta‐lactamases and were multidrug resistant. The PCR‐based pathotyping revealed the presence of stx1, stx2, eae and hlyA genes. The enterobacterial repetitive intergenic consensus PCR dendrogram analysis of the isolates yielded three distinct clusters. The statistical analysis revealed no association between carriages of carbapenem‐resistant E. coli in different breed of piglets however, location, sex, health status of piglets and age showed significant difference. The spatial analysis with SaTScan helped in identification of carbapenem‐resistant clusters.
Conclusions
The presence of carbapenem resistant E. coli isolates with virulence genes in the piglet poses a potential public health risk through possible access and spread via the food chain and environment. Efflux pump may also play an important role in carbapenem resistance in piglet E. coli isolates. Furthermore, identification of risk factors in relation to spatial clusters will help in designing preventive strategies for reducing the risk of spread of carbapenem resistant bacteria.
Significance and Impact of the Study
1. Piglets harbor carbapenem resistant E. coli and have great public health significance. 2. Apart from carbapenemase, efflux pump is also important for carbapenem resistance. 3. This is the first report of blaNDM in the piglets from India. |
| doi_str_mv | 10.1111/jam.13455 |
| format | Article |
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A cross‐sectional study was conducted in 10 government‐organized pig farms between 2014 and 2016 representing seven states of India to understand the epidemiology of carbapenem resistance in the Escherichia coli.
Methods and Results
In this study, fecal sample (n = 673) from non‐diarrheic (n = 501) and diarrheic (n = 172) piglets were processed for isolation of carbapenem resistant E. coli. Of 673, E. coli isolate (n = 112) was genotyped for confirming the carbapenem resistance and associated virulence factors. Of the 112 isolates, 23 were phenotypically resistant to carbapenem and 8 were carrying the New Delhi metallo beta‐lactamase (blaNDM) gene. The carbapenem‐resistant isolates also produced extended spectrum beta‐lactamases and were multidrug resistant. The PCR‐based pathotyping revealed the presence of stx1, stx2, eae and hlyA genes. The enterobacterial repetitive intergenic consensus PCR dendrogram analysis of the isolates yielded three distinct clusters. The statistical analysis revealed no association between carriages of carbapenem‐resistant E. coli in different breed of piglets however, location, sex, health status of piglets and age showed significant difference. The spatial analysis with SaTScan helped in identification of carbapenem‐resistant clusters.
Conclusions
The presence of carbapenem resistant E. coli isolates with virulence genes in the piglet poses a potential public health risk through possible access and spread via the food chain and environment. Efflux pump may also play an important role in carbapenem resistance in piglet E. coli isolates. Furthermore, identification of risk factors in relation to spatial clusters will help in designing preventive strategies for reducing the risk of spread of carbapenem resistant bacteria.
Significance and Impact of the Study
1. Piglets harbor carbapenem resistant E. coli and have great public health significance. 2. Apart from carbapenemase, efflux pump is also important for carbapenem resistance. 3. This is the first report of blaNDM in the piglets from India.</description><identifier>ISSN: 1364-5072</identifier><identifier>EISSN: 1365-2672</identifier><identifier>DOI: 10.1111/jam.13455</identifier><identifier>PMID: 28345184</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacteria ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; beta-Lactamases - genetics ; beta-Lactamases - metabolism ; blaNDM ; Carbapenemase ; Carbapenems - pharmacology ; Carriages ; Cluster analysis ; Cross-Sectional Studies ; Drug resistance ; Drug Resistance, Bacterial - genetics ; E coli ; E. coli ; Efflux ; Epidemiology ; Escherichia coli - drug effects ; Escherichia coli - genetics ; Escherichia coli - isolation & purification ; Escherichia coli - metabolism ; Farms ; Food chains ; Genes ; Genotype ; Health risks ; Hogs ; Humans ; Impact resistance ; India ; Metallography ; Microbial Sensitivity Tests ; Molecular Epidemiology ; Multidrug resistance ; piglets ; Polymerase chain reaction ; Public health ; Resistance factors ; Risk analysis ; Risk factors ; Risk reduction ; Spatial analysis ; spatial epidemiological analysis ; Statistical analysis ; Swine - microbiology ; Virulence ; Virulence factors ; Virulence Factors - genetics</subject><ispartof>Journal of applied microbiology, 2017-06, Vol.122 (6), p.1537-1546</ispartof><rights>2017 The Society for Applied Microbiology</rights><rights>2017 The Society for Applied Microbiology.</rights><rights>Copyright © 2017 The Society for Applied Microbiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-5213b4db3a19038f73d8fdd7f1b1ace470614ec0e5aa307bde6573044baefd4d3</citedby><cites>FETCH-LOGICAL-c3535-5213b4db3a19038f73d8fdd7f1b1ace470614ec0e5aa307bde6573044baefd4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjam.13455$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjam.13455$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28345184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pruthvishree, B.S.</creatorcontrib><creatorcontrib>Vinodh Kumar, O.R.</creatorcontrib><creatorcontrib>Sinha, D.K.</creatorcontrib><creatorcontrib>Malik, Y.P.S.</creatorcontrib><creatorcontrib>Dubal, Z.B.</creatorcontrib><creatorcontrib>Desingu, P.A.</creatorcontrib><creatorcontrib>Shivakumar, M.</creatorcontrib><creatorcontrib>Krishnaswamy, N.</creatorcontrib><creatorcontrib>Singh, B.R.</creatorcontrib><title>Spatial molecular epidemiology of carbapenem‐resistant and New Delhi metallo beta‐lactamase (blaNDM)‐producing Escherichia coli in the piglets of organized farms in India</title><title>Journal of applied microbiology</title><addtitle>J Appl Microbiol</addtitle><description>Aim
A cross‐sectional study was conducted in 10 government‐organized pig farms between 2014 and 2016 representing seven states of India to understand the epidemiology of carbapenem resistance in the Escherichia coli.
Methods and Results
In this study, fecal sample (n = 673) from non‐diarrheic (n = 501) and diarrheic (n = 172) piglets were processed for isolation of carbapenem resistant E. coli. Of 673, E. coli isolate (n = 112) was genotyped for confirming the carbapenem resistance and associated virulence factors. Of the 112 isolates, 23 were phenotypically resistant to carbapenem and 8 were carrying the New Delhi metallo beta‐lactamase (blaNDM) gene. The carbapenem‐resistant isolates also produced extended spectrum beta‐lactamases and were multidrug resistant. The PCR‐based pathotyping revealed the presence of stx1, stx2, eae and hlyA genes. The enterobacterial repetitive intergenic consensus PCR dendrogram analysis of the isolates yielded three distinct clusters. The statistical analysis revealed no association between carriages of carbapenem‐resistant E. coli in different breed of piglets however, location, sex, health status of piglets and age showed significant difference. The spatial analysis with SaTScan helped in identification of carbapenem‐resistant clusters.
Conclusions
The presence of carbapenem resistant E. coli isolates with virulence genes in the piglet poses a potential public health risk through possible access and spread via the food chain and environment. Efflux pump may also play an important role in carbapenem resistance in piglet E. coli isolates. Furthermore, identification of risk factors in relation to spatial clusters will help in designing preventive strategies for reducing the risk of spread of carbapenem resistant bacteria.
Significance and Impact of the Study
1. Piglets harbor carbapenem resistant E. coli and have great public health significance. 2. Apart from carbapenemase, efflux pump is also important for carbapenem resistance. 3. This is the first report of blaNDM in the piglets from India.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>beta-Lactamases - genetics</subject><subject>beta-Lactamases - metabolism</subject><subject>blaNDM</subject><subject>Carbapenemase</subject><subject>Carbapenems - pharmacology</subject><subject>Carriages</subject><subject>Cluster analysis</subject><subject>Cross-Sectional Studies</subject><subject>Drug resistance</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>E coli</subject><subject>E. coli</subject><subject>Efflux</subject><subject>Epidemiology</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli - isolation & purification</subject><subject>Escherichia coli - metabolism</subject><subject>Farms</subject><subject>Food chains</subject><subject>Genes</subject><subject>Genotype</subject><subject>Health risks</subject><subject>Hogs</subject><subject>Humans</subject><subject>Impact resistance</subject><subject>India</subject><subject>Metallography</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Epidemiology</subject><subject>Multidrug resistance</subject><subject>piglets</subject><subject>Polymerase chain reaction</subject><subject>Public health</subject><subject>Resistance factors</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Risk reduction</subject><subject>Spatial analysis</subject><subject>spatial epidemiological analysis</subject><subject>Statistical analysis</subject><subject>Swine - microbiology</subject><subject>Virulence</subject><subject>Virulence factors</subject><subject>Virulence Factors - genetics</subject><issn>1364-5072</issn><issn>1365-2672</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U9O3DAUBvCoalUodNELVJa6gUXAju38WSKglArognYdvdgvMx7ZcWonQsOqR-hROBMnwcPQLirVm2dZP31-0pdlHxg9Yukcr8AdMS6kfJXtMl7KvCir4vXzXeSSVsVO9i7GFaWMU1m-zXaKOmlWi93s4XaEyYAlzltUs4VAcDQanfHWL9bE90RB6GDEAd3jr98Bo4kTDBOBQZMbvCNnaJeGOJzAWk-6NBOzoCZwEJEcdBZuzq4P0-MYvJ6VGRbkPKolBqOWBojy1hAzkGmJZDQLi1Pc_OrDAgZzj5r0EFzciMtBG9jP3vRgI75_mXvZj8_n30-_5FffLi5PT65yxSWXuSwY74TuOLCG8rqvuK57rauedQwUioqWTKCiKAE4rTqNpaw4FaID7LXQfC872OamrX_OGKfWmajQWhjQz7Fldc2EaJpSJvrpH7rycxjSdkk1TVHWvORJHW6VCj7GgH07BuMgrFtG202Nbaqxfa4x2Y8viXPnUP-Vf3pL4HgL7ozF9f-T2q8n19vIJ5ClrFw</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Pruthvishree, B.S.</creator><creator>Vinodh Kumar, O.R.</creator><creator>Sinha, D.K.</creator><creator>Malik, Y.P.S.</creator><creator>Dubal, Z.B.</creator><creator>Desingu, P.A.</creator><creator>Shivakumar, M.</creator><creator>Krishnaswamy, N.</creator><creator>Singh, B.R.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Spatial molecular epidemiology of carbapenem‐resistant and New Delhi metallo beta‐lactamase (blaNDM)‐producing Escherichia coli in the piglets of organized farms in India</title><author>Pruthvishree, B.S. ; Vinodh Kumar, O.R. ; Sinha, D.K. ; Malik, Y.P.S. ; Dubal, Z.B. ; Desingu, P.A. ; Shivakumar, M. ; Krishnaswamy, N. ; Singh, B.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-5213b4db3a19038f73d8fdd7f1b1ace470614ec0e5aa307bde6573044baefd4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>beta-Lactamases - genetics</topic><topic>beta-Lactamases - metabolism</topic><topic>blaNDM</topic><topic>Carbapenemase</topic><topic>Carbapenems - pharmacology</topic><topic>Carriages</topic><topic>Cluster analysis</topic><topic>Cross-Sectional Studies</topic><topic>Drug resistance</topic><topic>Drug Resistance, Bacterial - genetics</topic><topic>E coli</topic><topic>E. coli</topic><topic>Efflux</topic><topic>Epidemiology</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli - isolation & purification</topic><topic>Escherichia coli - metabolism</topic><topic>Farms</topic><topic>Food chains</topic><topic>Genes</topic><topic>Genotype</topic><topic>Health risks</topic><topic>Hogs</topic><topic>Humans</topic><topic>Impact resistance</topic><topic>India</topic><topic>Metallography</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Epidemiology</topic><topic>Multidrug resistance</topic><topic>piglets</topic><topic>Polymerase chain reaction</topic><topic>Public health</topic><topic>Resistance factors</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Risk reduction</topic><topic>Spatial analysis</topic><topic>spatial epidemiological analysis</topic><topic>Statistical analysis</topic><topic>Swine - microbiology</topic><topic>Virulence</topic><topic>Virulence factors</topic><topic>Virulence Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pruthvishree, B.S.</creatorcontrib><creatorcontrib>Vinodh Kumar, O.R.</creatorcontrib><creatorcontrib>Sinha, D.K.</creatorcontrib><creatorcontrib>Malik, Y.P.S.</creatorcontrib><creatorcontrib>Dubal, Z.B.</creatorcontrib><creatorcontrib>Desingu, P.A.</creatorcontrib><creatorcontrib>Shivakumar, M.</creatorcontrib><creatorcontrib>Krishnaswamy, N.</creatorcontrib><creatorcontrib>Singh, B.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pruthvishree, B.S.</au><au>Vinodh Kumar, O.R.</au><au>Sinha, D.K.</au><au>Malik, Y.P.S.</au><au>Dubal, Z.B.</au><au>Desingu, P.A.</au><au>Shivakumar, M.</au><au>Krishnaswamy, N.</au><au>Singh, B.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial molecular epidemiology of carbapenem‐resistant and New Delhi metallo beta‐lactamase (blaNDM)‐producing Escherichia coli in the piglets of organized farms in India</atitle><jtitle>Journal of applied microbiology</jtitle><addtitle>J Appl Microbiol</addtitle><date>2017-06</date><risdate>2017</risdate><volume>122</volume><issue>6</issue><spage>1537</spage><epage>1546</epage><pages>1537-1546</pages><issn>1364-5072</issn><eissn>1365-2672</eissn><abstract>Aim
A cross‐sectional study was conducted in 10 government‐organized pig farms between 2014 and 2016 representing seven states of India to understand the epidemiology of carbapenem resistance in the Escherichia coli.
Methods and Results
In this study, fecal sample (n = 673) from non‐diarrheic (n = 501) and diarrheic (n = 172) piglets were processed for isolation of carbapenem resistant E. coli. Of 673, E. coli isolate (n = 112) was genotyped for confirming the carbapenem resistance and associated virulence factors. Of the 112 isolates, 23 were phenotypically resistant to carbapenem and 8 were carrying the New Delhi metallo beta‐lactamase (blaNDM) gene. The carbapenem‐resistant isolates also produced extended spectrum beta‐lactamases and were multidrug resistant. The PCR‐based pathotyping revealed the presence of stx1, stx2, eae and hlyA genes. The enterobacterial repetitive intergenic consensus PCR dendrogram analysis of the isolates yielded three distinct clusters. The statistical analysis revealed no association between carriages of carbapenem‐resistant E. coli in different breed of piglets however, location, sex, health status of piglets and age showed significant difference. The spatial analysis with SaTScan helped in identification of carbapenem‐resistant clusters.
Conclusions
The presence of carbapenem resistant E. coli isolates with virulence genes in the piglet poses a potential public health risk through possible access and spread via the food chain and environment. Efflux pump may also play an important role in carbapenem resistance in piglet E. coli isolates. Furthermore, identification of risk factors in relation to spatial clusters will help in designing preventive strategies for reducing the risk of spread of carbapenem resistant bacteria.
Significance and Impact of the Study
1. Piglets harbor carbapenem resistant E. coli and have great public health significance. 2. Apart from carbapenemase, efflux pump is also important for carbapenem resistance. 3. This is the first report of blaNDM in the piglets from India.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28345184</pmid><doi>10.1111/jam.13455</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of applied microbiology, 2017-06, Vol.122 (6), p.1537-1546 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism beta-Lactamases - genetics beta-Lactamases - metabolism blaNDM Carbapenemase Carbapenems - pharmacology Carriages Cluster analysis Cross-Sectional Studies Drug resistance Drug Resistance, Bacterial - genetics E coli E. coli Efflux Epidemiology Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli - metabolism Farms Food chains Genes Genotype Health risks Hogs Humans Impact resistance India Metallography Microbial Sensitivity Tests Molecular Epidemiology Multidrug resistance piglets Polymerase chain reaction Public health Resistance factors Risk analysis Risk factors Risk reduction Spatial analysis spatial epidemiological analysis Statistical analysis Swine - microbiology Virulence Virulence factors Virulence Factors - genetics |
| title | Spatial molecular epidemiology of carbapenem‐resistant and New Delhi metallo beta‐lactamase (blaNDM)‐producing Escherichia coli in the piglets of organized farms in India |
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