Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution

Active DNA demethylation in mammals involves ten-eleven translocation (TET) family protein-mediated oxidation of 5-methylcytosine (5mC). However, base-resolution landscapes of 5-formylcytosine (5fC) (an oxidized derivative of 5mC) at the single-cell level remain unexplored. Here, we present “CLEVER-...

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Veröffentlicht in:	Cell stem cell 2017-05, Vol.20 (5), p.720-731.e5
Hauptverfasser:	Zhu, Chenxu, Gao, Yun, Guo, Hongshan, Xia, Bo, Song, Jinghui, Wu, Xinglong, Zeng, Hu, Kee, Kehkooi, Tang, Fuchou, Yi, Chengqi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-formylcytosine active DNA demethylation Animals biocompatible labeling CLEVER-seq Cytosine - analogs & derivatives Cytosine - metabolism DNA Methylation - genetics early embryo Embryo, Mammalian - metabolism Embryonic Stem Cells - metabolism ESC Gene Expression Regulation heterogeneity Mice Promoter Regions, Genetic - genetics single-cell sequencing
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