Neutrophil-derived mitochondrial DNA promotes receptor activator of nuclear factor κB and its ligand signalling in rheumatoid arthritis

Mitochondrial DNA (mtDNA) contains sequestered damage-associated molecular patterns that might be involved in osteoimmunological pathogenesis of RA. Here, we aimed to investigate the cellular source of mtDNA and its role in RANK ligand (RANKL) expression by RA SF neutrophils. The gene expression sig...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2017-07, Vol.56 (7), p.1200-1205
Hauptverfasser:	Contis, Anne, Mitrovic, Stéphane, Lavie, Julie, Douchet, Isabelle, Lazaro, Estibaliz, Truchetet, Marie-Elise, Goizet, Cyril, Contin-Bordes, Cécile, Schaeverbeke, Thierry, Blanco, Patrick, Rossignol, Rodrigue, Faustin, Benjamin, Richez, Christophe, Duffau, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Case-Control Studies DNA, Mitochondrial - metabolism Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Gene Expression Regulation Humans Male Middle Aged Neutrophils - metabolism Oxidative Stress - genetics RANK Ligand - genetics Real-Time Polymerase Chain Reaction - methods Receptor Activator of Nuclear Factor-kappa B - genetics Reference Values Retrospective Studies Signal Transduction - genetics
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