Thoracic Endovascular Aortic Repair for Type B Acute Aortic Dissection Complicated by Descending Thoracic Aneurysm

Objectives To analyse the results and review the literature about thoracic aortic endovascular repair (TEVAR) for type B acute aortic dissection (TBAAD) complicated by descending thoracic aortic aneurysm (DTA) in the hyperacute or acute phases. Methods This was a multicentre, observational descripti...

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Veröffentlicht in:European journal of vascular and endovascular surgery 2017-06, Vol.53 (6), p.793-801
Hauptverfasser: Piffaretti, G, Ottavi, P, Lomazzi, C, Franchin, M, Micheli, R, Ferilli, F, Dorigo, W, Marrocco-Trischitta, M, Castelli, P, Trimarchi, S
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container_end_page 801
container_issue 6
container_start_page 793
container_title European journal of vascular and endovascular surgery
container_volume 53
creator Piffaretti, G
Ottavi, P
Lomazzi, C
Franchin, M
Micheli, R
Ferilli, F
Dorigo, W
Marrocco-Trischitta, M
Castelli, P
Trimarchi, S
description Objectives To analyse the results and review the literature about thoracic aortic endovascular repair (TEVAR) for type B acute aortic dissection (TBAAD) complicated by descending thoracic aortic aneurysm (DTA) in the hyperacute or acute phases. Methods This was a multicentre, observational descriptive study. Inclusion criteria were TBAAD with a DTA of ≥50 mm, TBAAD on an already known aneurysmal descending thoracic aorta, and TBAAD presenting with an enlarged aorta with a total diameter 50% diameter increase compared with a previous computed tomography angiography (CTA) showing a non-dissected aorta with normal sizing. Primary endpoints were early and long-term survival, freedom from TEVAR and aortic related mortality (ARM), and freedom from re-intervention. Results Twenty-two patients were included in the analysis. The mean aortic diameter was 66 ± 26 mm (range 42–130; IQR 51–64). The in hospital TEVAR related mortality was 14% ( n  = 3). The mean radiological follow-up was 56 ± 45 months (range 6–149; IQR 12–82), and the follow-up index 0.97 ± 0.1. All surviving patients were available for follow-up. During follow-up the cumulative mortality was 26% ( n  = 5) and TEVAR related mortality was 5% (n = 1). Overall the estimate of survival was 82% (95%CI: 61.5–93) at 1 year, and 64% at 5 years. Ongoing primary clinical success was 79% (re-intervention n  = 4). Freedom from aortic related mortality was 86% (95%CI: 66–95) at 1 and 5 year, while freedom from re-intervention was 95% (95%CI: 75.5–95) at 1 year, and 77% (95%CI: 50–92) at 5 years. Conclusions In our experience, DTA is a frequent complication from the very beginning of the clinical onset of TBAAD. In this high-risk cohort, TEVAR showed satisfactory results, better than those predicted by the risk score for open repair, with favourable stability of the aortic diameter and no aortic related adverse events during follow-up.
doi_str_mv 10.1016/j.ejvs.2017.02.022
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Methods This was a multicentre, observational descriptive study. Inclusion criteria were TBAAD with a DTA of ≥50 mm, TBAAD on an already known aneurysmal descending thoracic aorta, and TBAAD presenting with an enlarged aorta with a total diameter &lt;50 mm, but with &gt;50% diameter increase compared with a previous computed tomography angiography (CTA) showing a non-dissected aorta with normal sizing. Primary endpoints were early and long-term survival, freedom from TEVAR and aortic related mortality (ARM), and freedom from re-intervention. Results Twenty-two patients were included in the analysis. The mean aortic diameter was 66 ± 26 mm (range 42–130; IQR 51–64). The in hospital TEVAR related mortality was 14% ( n  = 3). The mean radiological follow-up was 56 ± 45 months (range 6–149; IQR 12–82), and the follow-up index 0.97 ± 0.1. All surviving patients were available for follow-up. During follow-up the cumulative mortality was 26% ( n  = 5) and TEVAR related mortality was 5% (n = 1). Overall the estimate of survival was 82% (95%CI: 61.5–93) at 1 year, and 64% at 5 years. Ongoing primary clinical success was 79% (re-intervention n  = 4). Freedom from aortic related mortality was 86% (95%CI: 66–95) at 1 and 5 year, while freedom from re-intervention was 95% (95%CI: 75.5–95) at 1 year, and 77% (95%CI: 50–92) at 5 years. Conclusions In our experience, DTA is a frequent complication from the very beginning of the clinical onset of TBAAD. In this high-risk cohort, TEVAR showed satisfactory results, better than those predicted by the risk score for open repair, with favourable stability of the aortic diameter and no aortic related adverse events during follow-up.</description><identifier>ISSN: 1078-5884</identifier><identifier>EISSN: 1532-2165</identifier><identifier>DOI: 10.1016/j.ejvs.2017.02.022</identifier><identifier>PMID: 28341530</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acute Disease ; Aged ; Aneurysm ; Aneurysm, Dissecting - diagnostic imaging ; Aneurysm, Dissecting - mortality ; Aneurysm, Dissecting - surgery ; Aortic Aneurysm, Thoracic - diagnostic imaging ; Aortic Aneurysm, Thoracic - mortality ; Aortic Aneurysm, Thoracic - surgery ; Aortography - methods ; Blood Vessel Prosthesis Implantation - adverse effects ; Blood Vessel Prosthesis Implantation - mortality ; Complicated type B acute aortic dissection ; Computed Tomography Angiography ; Disease-Free Survival ; Endovascular Procedures - adverse effects ; Endovascular Procedures - mortality ; Female ; Humans ; Italy ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Surgery ; Time Factors ; Treatment Outcome</subject><ispartof>European journal of vascular and endovascular surgery, 2017-06, Vol.53 (6), p.793-801</ispartof><rights>European Society for Vascular Surgery</rights><rights>2017 European Society for Vascular Surgery</rights><rights>Copyright © 2017 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-2f51837427b9c9048cedaa9c23ae80d25b626c65b5d90f546b08abbf6ba8fa853</citedby><cites>FETCH-LOGICAL-c455t-2f51837427b9c9048cedaa9c23ae80d25b626c65b5d90f546b08abbf6ba8fa853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejvs.2017.02.022$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28341530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piffaretti, G</creatorcontrib><creatorcontrib>Ottavi, P</creatorcontrib><creatorcontrib>Lomazzi, C</creatorcontrib><creatorcontrib>Franchin, M</creatorcontrib><creatorcontrib>Micheli, R</creatorcontrib><creatorcontrib>Ferilli, F</creatorcontrib><creatorcontrib>Dorigo, W</creatorcontrib><creatorcontrib>Marrocco-Trischitta, M</creatorcontrib><creatorcontrib>Castelli, P</creatorcontrib><creatorcontrib>Trimarchi, S</creatorcontrib><title>Thoracic Endovascular Aortic Repair for Type B Acute Aortic Dissection Complicated by Descending Thoracic Aneurysm</title><title>European journal of vascular and endovascular surgery</title><addtitle>Eur J Vasc Endovasc Surg</addtitle><description>Objectives To analyse the results and review the literature about thoracic aortic endovascular repair (TEVAR) for type B acute aortic dissection (TBAAD) complicated by descending thoracic aortic aneurysm (DTA) in the hyperacute or acute phases. Methods This was a multicentre, observational descriptive study. Inclusion criteria were TBAAD with a DTA of ≥50 mm, TBAAD on an already known aneurysmal descending thoracic aorta, and TBAAD presenting with an enlarged aorta with a total diameter &lt;50 mm, but with &gt;50% diameter increase compared with a previous computed tomography angiography (CTA) showing a non-dissected aorta with normal sizing. Primary endpoints were early and long-term survival, freedom from TEVAR and aortic related mortality (ARM), and freedom from re-intervention. Results Twenty-two patients were included in the analysis. The mean aortic diameter was 66 ± 26 mm (range 42–130; IQR 51–64). The in hospital TEVAR related mortality was 14% ( n  = 3). The mean radiological follow-up was 56 ± 45 months (range 6–149; IQR 12–82), and the follow-up index 0.97 ± 0.1. All surviving patients were available for follow-up. During follow-up the cumulative mortality was 26% ( n  = 5) and TEVAR related mortality was 5% (n = 1). Overall the estimate of survival was 82% (95%CI: 61.5–93) at 1 year, and 64% at 5 years. Ongoing primary clinical success was 79% (re-intervention n  = 4). Freedom from aortic related mortality was 86% (95%CI: 66–95) at 1 and 5 year, while freedom from re-intervention was 95% (95%CI: 75.5–95) at 1 year, and 77% (95%CI: 50–92) at 5 years. Conclusions In our experience, DTA is a frequent complication from the very beginning of the clinical onset of TBAAD. 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Methods This was a multicentre, observational descriptive study. Inclusion criteria were TBAAD with a DTA of ≥50 mm, TBAAD on an already known aneurysmal descending thoracic aorta, and TBAAD presenting with an enlarged aorta with a total diameter &lt;50 mm, but with &gt;50% diameter increase compared with a previous computed tomography angiography (CTA) showing a non-dissected aorta with normal sizing. Primary endpoints were early and long-term survival, freedom from TEVAR and aortic related mortality (ARM), and freedom from re-intervention. Results Twenty-two patients were included in the analysis. The mean aortic diameter was 66 ± 26 mm (range 42–130; IQR 51–64). The in hospital TEVAR related mortality was 14% ( n  = 3). The mean radiological follow-up was 56 ± 45 months (range 6–149; IQR 12–82), and the follow-up index 0.97 ± 0.1. All surviving patients were available for follow-up. During follow-up the cumulative mortality was 26% ( n  = 5) and TEVAR related mortality was 5% (n = 1). Overall the estimate of survival was 82% (95%CI: 61.5–93) at 1 year, and 64% at 5 years. Ongoing primary clinical success was 79% (re-intervention n  = 4). Freedom from aortic related mortality was 86% (95%CI: 66–95) at 1 and 5 year, while freedom from re-intervention was 95% (95%CI: 75.5–95) at 1 year, and 77% (95%CI: 50–92) at 5 years. Conclusions In our experience, DTA is a frequent complication from the very beginning of the clinical onset of TBAAD. In this high-risk cohort, TEVAR showed satisfactory results, better than those predicted by the risk score for open repair, with favourable stability of the aortic diameter and no aortic related adverse events during follow-up.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28341530</pmid><doi>10.1016/j.ejvs.2017.02.022</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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subjects Acute Disease
Aged
Aneurysm
Aneurysm, Dissecting - diagnostic imaging
Aneurysm, Dissecting - mortality
Aneurysm, Dissecting - surgery
Aortic Aneurysm, Thoracic - diagnostic imaging
Aortic Aneurysm, Thoracic - mortality
Aortic Aneurysm, Thoracic - surgery
Aortography - methods
Blood Vessel Prosthesis Implantation - adverse effects
Blood Vessel Prosthesis Implantation - mortality
Complicated type B acute aortic dissection
Computed Tomography Angiography
Disease-Free Survival
Endovascular Procedures - adverse effects
Endovascular Procedures - mortality
Female
Humans
Italy
Kaplan-Meier Estimate
Male
Middle Aged
Retrospective Studies
Risk Factors
Surgery
Time Factors
Treatment Outcome
title Thoracic Endovascular Aortic Repair for Type B Acute Aortic Dissection Complicated by Descending Thoracic Aneurysm
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