Birmingham vasculitis activity score at diagnosis is a significant predictor of relapse of polyarteritis nodosa
The objective of this study was to investigate whether clinical and laboratory data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse in 30 patients with polyarteritis nodosa (PAN) having the follow-up duration for over 12 months. We reviewe...
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| Veröffentlicht in: | Rheumatology international 2017-05, Vol.37 (5), p.685-694 |
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| creator | Oh, Yoon-Jeong Ahn, Sung Soo Park, Eun Seong Jung, Seung Min Song, Jason Jungsik Park, Yong-Beom Lee, Sang-Won |
| description | The objective of this study was to investigate whether clinical and laboratory data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse in 30 patients with polyarteritis nodosa (PAN) having the follow-up duration for over 12 months. We reviewed the medical charts of 30 patients with PAN. We obtained clinical and laboratory data at diagnosis, and we compared them between the two groups based on relapse. The optimal cut-off values of BVAS and FFS (1996) at diagnosis to predict relapse were extrapolated. The mean age of patients (15 men) was 50.8 years, and the mean follow-up duration was 64.1 months. Nine patients (30.0%) had experience relapse after remission. Patients having relapse showed the higher frequency of weight loss and ocular symptoms and the less frequency of diastolic hypertension than those having not (
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| doi_str_mv | 10.1007/s00296-017-3706-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1881269121</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4321814371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-acff7316dd31f6db3c8b12dc0c8252e44501898c21c961df2446cc5cb5e6aec93</originalsourceid><addsrcrecordid>eNp1kUtv1TAQhS0EopfCD2CDLLFhE-pxEsdZQlUeUqVuWomd5Tt2Lq6SOHicSvff43ALQkhs_ND55ow9h7HXIN6DEN0FCSF7VQnoqroTqmqfsB00dVeBEt-esl0RZKXLcsZeEN2LcldKPGdnUtcNaA07Fj-GNIX58N1O_MESrmPIgbjFHB5CPnLCmDy3mbtgD3Okom0yp3CYwxDQzpkvybuAOSYeB578aBfy23GJ49Gm7NMvyzm6SPYlezbYkfyrx_2c3X26ur38Ul3ffP56-eG6wrqTubI4DF0NyrkaBuX2Neo9SIcCtWylb5pWgO41SsBegRtk0yjEFvetV9ZjX5-zdyffJcUfq6dspkDox9HOPq5ktt9L1YOEgr79B72Pa5rL6zaqbxqQnS4UnChMkSj5wSwpTDYdDQizpWFOaZgyZLOlYdpS8-bRed1P3v2p-D3-AsgTQEWaDz791fq_rj8BffiW3Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1889441278</pqid></control><display><type>article</type><title>Birmingham vasculitis activity score at diagnosis is a significant predictor of relapse of polyarteritis nodosa</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Oh, Yoon-Jeong ; Ahn, Sung Soo ; Park, Eun Seong ; Jung, Seung Min ; Song, Jason Jungsik ; Park, Yong-Beom ; Lee, Sang-Won</creator><creatorcontrib>Oh, Yoon-Jeong ; Ahn, Sung Soo ; Park, Eun Seong ; Jung, Seung Min ; Song, Jason Jungsik ; Park, Yong-Beom ; Lee, Sang-Won</creatorcontrib><description>The objective of this study was to investigate whether clinical and laboratory data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse in 30 patients with polyarteritis nodosa (PAN) having the follow-up duration for over 12 months. We reviewed the medical charts of 30 patients with PAN. We obtained clinical and laboratory data at diagnosis, and we compared them between the two groups based on relapse. The optimal cut-off values of BVAS and FFS (1996) at diagnosis to predict relapse were extrapolated. The mean age of patients (15 men) was 50.8 years, and the mean follow-up duration was 64.1 months. Nine patients (30.0%) had experience relapse after remission. Patients having relapse showed the higher frequency of weight loss and ocular symptoms and the less frequency of diastolic hypertension than those having not (
p
< 0.005 for all). On multivariate logistic regression analysis, weight loss was the only independent predictor of relapse, but on Cox Hazard model analysis, its statistical significance disappeared. The mean initial BVAS and FFS (1996) of patients in relapse group were higher than those of patients in no relapse group (
p
< 0.005 for all). Patients having initial BVAS over 13.5 and FFS (1996) over 1 exhibited significantly higher risk of relapse than those having not (RR 40.0 and RR 7.0, respectively). However, initial BVAS over 13.5 only remained significant in Kaplan–Meier survival analysis. In conclusion, BVAS over 13.5 at diagnosis was the only independent predictor of relapse of PAN.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-017-3706-5</identifier><identifier>PMID: 28341881</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Observational Research ; Polyarteritis Nodosa - diagnosis ; Predictive Value of Tests ; Prognosis ; Recurrence ; Rheumatology ; Severity of Illness Index ; Vasculitis - diagnosis</subject><ispartof>Rheumatology international, 2017-05, Vol.37 (5), p.685-694</ispartof><rights>Springer-Verlag Berlin Heidelberg 2017</rights><rights>Rheumatology International is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-acff7316dd31f6db3c8b12dc0c8252e44501898c21c961df2446cc5cb5e6aec93</citedby><cites>FETCH-LOGICAL-c372t-acff7316dd31f6db3c8b12dc0c8252e44501898c21c961df2446cc5cb5e6aec93</cites><orcidid>0000-0002-8038-3341</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-017-3706-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-017-3706-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28341881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Yoon-Jeong</creatorcontrib><creatorcontrib>Ahn, Sung Soo</creatorcontrib><creatorcontrib>Park, Eun Seong</creatorcontrib><creatorcontrib>Jung, Seung Min</creatorcontrib><creatorcontrib>Song, Jason Jungsik</creatorcontrib><creatorcontrib>Park, Yong-Beom</creatorcontrib><creatorcontrib>Lee, Sang-Won</creatorcontrib><title>Birmingham vasculitis activity score at diagnosis is a significant predictor of relapse of polyarteritis nodosa</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>The objective of this study was to investigate whether clinical and laboratory data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse in 30 patients with polyarteritis nodosa (PAN) having the follow-up duration for over 12 months. We reviewed the medical charts of 30 patients with PAN. We obtained clinical and laboratory data at diagnosis, and we compared them between the two groups based on relapse. The optimal cut-off values of BVAS and FFS (1996) at diagnosis to predict relapse were extrapolated. The mean age of patients (15 men) was 50.8 years, and the mean follow-up duration was 64.1 months. Nine patients (30.0%) had experience relapse after remission. Patients having relapse showed the higher frequency of weight loss and ocular symptoms and the less frequency of diastolic hypertension than those having not (
p
< 0.005 for all). On multivariate logistic regression analysis, weight loss was the only independent predictor of relapse, but on Cox Hazard model analysis, its statistical significance disappeared. The mean initial BVAS and FFS (1996) of patients in relapse group were higher than those of patients in no relapse group (
p
< 0.005 for all). Patients having initial BVAS over 13.5 and FFS (1996) over 1 exhibited significantly higher risk of relapse than those having not (RR 40.0 and RR 7.0, respectively). However, initial BVAS over 13.5 only remained significant in Kaplan–Meier survival analysis. In conclusion, BVAS over 13.5 at diagnosis was the only independent predictor of relapse of PAN.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Observational Research</subject><subject>Polyarteritis Nodosa - diagnosis</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Rheumatology</subject><subject>Severity of Illness Index</subject><subject>Vasculitis - diagnosis</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUtv1TAQhS0EopfCD2CDLLFhE-pxEsdZQlUeUqVuWomd5Tt2Lq6SOHicSvff43ALQkhs_ND55ow9h7HXIN6DEN0FCSF7VQnoqroTqmqfsB00dVeBEt-esl0RZKXLcsZeEN2LcldKPGdnUtcNaA07Fj-GNIX58N1O_MESrmPIgbjFHB5CPnLCmDy3mbtgD3Okom0yp3CYwxDQzpkvybuAOSYeB578aBfy23GJ49Gm7NMvyzm6SPYlezbYkfyrx_2c3X26ur38Ul3ffP56-eG6wrqTubI4DF0NyrkaBuX2Neo9SIcCtWylb5pWgO41SsBegRtk0yjEFvetV9ZjX5-zdyffJcUfq6dspkDox9HOPq5ktt9L1YOEgr79B72Pa5rL6zaqbxqQnS4UnChMkSj5wSwpTDYdDQizpWFOaZgyZLOlYdpS8-bRed1P3v2p-D3-AsgTQEWaDz791fq_rj8BffiW3Q</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Oh, Yoon-Jeong</creator><creator>Ahn, Sung Soo</creator><creator>Park, Eun Seong</creator><creator>Jung, Seung Min</creator><creator>Song, Jason Jungsik</creator><creator>Park, Yong-Beom</creator><creator>Lee, Sang-Won</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8038-3341</orcidid></search><sort><creationdate>20170501</creationdate><title>Birmingham vasculitis activity score at diagnosis is a significant predictor of relapse of polyarteritis nodosa</title><author>Oh, Yoon-Jeong ; Ahn, Sung Soo ; Park, Eun Seong ; Jung, Seung Min ; Song, Jason Jungsik ; Park, Yong-Beom ; Lee, Sang-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-acff7316dd31f6db3c8b12dc0c8252e44501898c21c961df2446cc5cb5e6aec93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Observational Research</topic><topic>Polyarteritis Nodosa - diagnosis</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Rheumatology</topic><topic>Severity of Illness Index</topic><topic>Vasculitis - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Yoon-Jeong</creatorcontrib><creatorcontrib>Ahn, Sung Soo</creatorcontrib><creatorcontrib>Park, Eun Seong</creatorcontrib><creatorcontrib>Jung, Seung Min</creatorcontrib><creatorcontrib>Song, Jason Jungsik</creatorcontrib><creatorcontrib>Park, Yong-Beom</creatorcontrib><creatorcontrib>Lee, Sang-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Yoon-Jeong</au><au>Ahn, Sung Soo</au><au>Park, Eun Seong</au><au>Jung, Seung Min</au><au>Song, Jason Jungsik</au><au>Park, Yong-Beom</au><au>Lee, Sang-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Birmingham vasculitis activity score at diagnosis is a significant predictor of relapse of polyarteritis nodosa</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>37</volume><issue>5</issue><spage>685</spage><epage>694</epage><pages>685-694</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>The objective of this study was to investigate whether clinical and laboratory data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse in 30 patients with polyarteritis nodosa (PAN) having the follow-up duration for over 12 months. We reviewed the medical charts of 30 patients with PAN. We obtained clinical and laboratory data at diagnosis, and we compared them between the two groups based on relapse. The optimal cut-off values of BVAS and FFS (1996) at diagnosis to predict relapse were extrapolated. The mean age of patients (15 men) was 50.8 years, and the mean follow-up duration was 64.1 months. Nine patients (30.0%) had experience relapse after remission. Patients having relapse showed the higher frequency of weight loss and ocular symptoms and the less frequency of diastolic hypertension than those having not (
p
< 0.005 for all). On multivariate logistic regression analysis, weight loss was the only independent predictor of relapse, but on Cox Hazard model analysis, its statistical significance disappeared. The mean initial BVAS and FFS (1996) of patients in relapse group were higher than those of patients in no relapse group (
p
< 0.005 for all). Patients having initial BVAS over 13.5 and FFS (1996) over 1 exhibited significantly higher risk of relapse than those having not (RR 40.0 and RR 7.0, respectively). However, initial BVAS over 13.5 only remained significant in Kaplan–Meier survival analysis. In conclusion, BVAS over 13.5 at diagnosis was the only independent predictor of relapse of PAN.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28341881</pmid><doi>10.1007/s00296-017-3706-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8038-3341</orcidid></addata></record> |
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| ispartof | Rheumatology international, 2017-05, Vol.37 (5), p.685-694 |
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| subjects | Adult Aged Female Humans Male Medicine Medicine & Public Health Middle Aged Observational Research Polyarteritis Nodosa - diagnosis Predictive Value of Tests Prognosis Recurrence Rheumatology Severity of Illness Index Vasculitis - diagnosis |
| title | Birmingham vasculitis activity score at diagnosis is a significant predictor of relapse of polyarteritis nodosa |
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