Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia

Ventricular tachycardia (VT) is common in cardiomyopathy patients with an implantable cardioverter-defibrillator. This analysis evaluated antiarrhythmic medication use and change in use over time in patients with VT and structural heart disease. Query of Medicare claims identified patients with an i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The American journal of cardiology 2017-05, Vol.119 (9), p.1401-1406
Hauptverfasser: Pokorney, Sean D., MD, MBA, Mi, Xiaojuan, PhD, Hammill, Bradley G., DrPH, Allen LaPointe, Nancy M., PharmD, MHS, Curtis, Lesley H., PhD, Al-Khatib, Sana M., MD, MHS
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1406
container_issue 9
container_start_page 1401
container_title The American journal of cardiology
container_volume 119
creator Pokorney, Sean D., MD, MBA
Mi, Xiaojuan, PhD
Hammill, Bradley G., DrPH
Allen LaPointe, Nancy M., PharmD, MHS
Curtis, Lesley H., PhD
Al-Khatib, Sana M., MD, MHS
description Ventricular tachycardia (VT) is common in cardiomyopathy patients with an implantable cardioverter-defibrillator. This analysis evaluated antiarrhythmic medication use and change in use over time in patients with VT and structural heart disease. Query of Medicare claims identified patients with an implantable cardioverter-defibrillator and VT. Patients with atrial fibrillation or supraventricular tachycardia were excluded. Two cohorts were created of patients enrolled in Medicare Part D for the 12 months before 2007 and 2012. Patients were identified through a search for antiarrhythmic medication fills with a supply covering January 1 of the cohort year. Adjusted logistic regression modeling evaluated the association between patient characteristics and antiarrhythmic medication use. The 2007 (n = 2,334) and 2012 (n = 3,892) Medicare Part D cohorts had similar demographics: median age 76 years, 64%-67% male, and 87%-89% white. Of the 2007 cohort, 1,380 (59%) patients were on a beta blocker, and 484 (20.7%) were on an antiarrhythmic medication (70% amiodarone and 20% sotalol). Between 2007 and 2012, there was a statistically significant higher use of any antiarrhythmic medication (p = 0.014), beta blockers (p 
doi_str_mv 10.1016/j.amjcard.2017.01.030
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1881269004</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002914917301297</els_id><sourcerecordid>1888122569</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-d2712024bb854ddd8f165ba1eb3ae703f590a8274d55ef13d0f63e778313e1f53</originalsourceid><addsrcrecordid>eNqFkkuLFDEQgBtR3HH1JygBL166rUr6eVGWWR8LKwru6jGkk2ombT_GJL0w_8CfbZoZFfbiKRR8Vamqr5LkOUKGgOXrPlNjr5UzGQesMsAMBDxINlhXTYoNiofJBgB42mDenCVPvO9jiFiUj5MzXoscRQmb5NetJzZ37GIKVjm3O4TdaDX7RMZqFew8eWanU-iIfVEusMv4BEtT8Oy7DTumJnY17gc1BdUOxLaxKTvfkQvk0kvqbOvsMKgwu0ga9i0mOquXQTl2o_TusA5h1dPkUacGT89O73ly-_7dzfZjev35w9X24jrVeV6H1PAKOfC8besiN8bUHZZFq5BaoagC0RUNqJpXuSkK6lAY6EpBVVULFIRdIc6TV8e6ezf_XMgHOVqvKTY40bx4iXWNvGwA8oi-vIf28-Km2N1KRYwXZROp4khpN3vvqJN7Z0flDhJBrqpkL0-q5KpKAsqoKua9OFVf2pHM36w_biLw9ghQXMedJSe9jlvX0YUjHaSZ7X-_eHOvgh7sFE0OP-hA_t800nMJ8ut6L-u5YCUAeVOJ38QyvO8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1888122569</pqid></control><display><type>article</type><title>Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Pokorney, Sean D., MD, MBA ; Mi, Xiaojuan, PhD ; Hammill, Bradley G., DrPH ; Allen LaPointe, Nancy M., PharmD, MHS ; Curtis, Lesley H., PhD ; Al-Khatib, Sana M., MD, MHS</creator><creatorcontrib>Pokorney, Sean D., MD, MBA ; Mi, Xiaojuan, PhD ; Hammill, Bradley G., DrPH ; Allen LaPointe, Nancy M., PharmD, MHS ; Curtis, Lesley H., PhD ; Al-Khatib, Sana M., MD, MHS</creatorcontrib><description>Ventricular tachycardia (VT) is common in cardiomyopathy patients with an implantable cardioverter-defibrillator. This analysis evaluated antiarrhythmic medication use and change in use over time in patients with VT and structural heart disease. Query of Medicare claims identified patients with an implantable cardioverter-defibrillator and VT. Patients with atrial fibrillation or supraventricular tachycardia were excluded. Two cohorts were created of patients enrolled in Medicare Part D for the 12 months before 2007 and 2012. Patients were identified through a search for antiarrhythmic medication fills with a supply covering January 1 of the cohort year. Adjusted logistic regression modeling evaluated the association between patient characteristics and antiarrhythmic medication use. The 2007 (n = 2,334) and 2012 (n = 3,892) Medicare Part D cohorts had similar demographics: median age 76 years, 64%-67% male, and 87%-89% white. Of the 2007 cohort, 1,380 (59%) patients were on a beta blocker, and 484 (20.7%) were on an antiarrhythmic medication (70% amiodarone and 20% sotalol). Between 2007 and 2012, there was a statistically significant higher use of any antiarrhythmic medication (p = 0.014), beta blockers (p &lt;0.0001), mexiletine (p = 0.005), and ranolazine (p &lt;0.0001), while amiodarone use remained unchanged (p = 0.53). After multivariable adjustment, male gender and renal disease were associated with higher antiarrhythmic medication use. In conclusion, although antiarrhythmic medication and beta blocker use in patients with VT increased over time, &lt;1 in 4 patients were on an antiarrhythmic medication and only 65% of the patients were on a beta blocker.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2017.01.030</identifier><identifier>PMID: 28341360</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ablation ; Acute coronary syndromes ; Adrenergic beta-Antagonists - therapeutic use ; Aged ; Aged, 80 and over ; Amiodarone ; Amiodarone - therapeutic use ; Anemia ; Anomalies ; Anti-Arrhythmia Agents - therapeutic use ; Antiarrhythmics ; Arrhythmia ; Atenolol ; Cancer ; Cardiac arrhythmia ; Cardiomyopathy ; Cardiovascular ; Cardiovascular disease ; Cardiovascular diseases ; Cerebral infarction ; Chronic obstructive pulmonary disease ; Circulation ; Classification ; Clinical trials ; Codes ; Complications ; Congenital defects ; Congestive heart failure ; Coronary artery ; Coronary artery disease ; Coronary vessels ; Damage ; Databases, Factual ; Death, Sudden, Cardiac - prevention &amp; control ; Defibrillators, Implantable ; Diabetes mellitus ; Diagnosis ; Drugs ; Electric Countershock ; Electrocardiography ; Enrollments ; Female ; Generic drugs ; Government programs ; Guidelines ; Health care ; Health risks ; Heart ; Heart attacks ; Heart failure ; Hospitals ; Humans ; Hypertension ; Incidence ; Intervention ; Ischemia ; Kidney transplantation ; Logistic Models ; Lung diseases ; Male ; Mathematical models ; Medical instruments ; Medicare ; Medicare Part D ; Mexiletine - therapeutic use ; Mortality ; Myocardial infarction ; Patients ; Population studies ; Populations ; Prescription drugs ; Prevention ; Quality of life ; Ranolazine - therapeutic use ; Regression analysis ; Renal failure ; Risk ; Skin ; Sodium Channel Blockers - therapeutic use ; Sotalol - therapeutic use ; Statistical tests ; Stroke ; Survival ; Tachycardia, Ventricular - therapy ; Terminology ; Transplants &amp; implants ; United States ; Ventricle</subject><ispartof>The American journal of cardiology, 2017-05, Vol.119 (9), p.1401-1406</ispartof><rights>Elsevier Inc.</rights><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited May 1, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-d2712024bb854ddd8f165ba1eb3ae703f590a8274d55ef13d0f63e778313e1f53</citedby><cites>FETCH-LOGICAL-c448t-d2712024bb854ddd8f165ba1eb3ae703f590a8274d55ef13d0f63e778313e1f53</cites><orcidid>0000-0002-4345-0816</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002914917301297$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28341360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pokorney, Sean D., MD, MBA</creatorcontrib><creatorcontrib>Mi, Xiaojuan, PhD</creatorcontrib><creatorcontrib>Hammill, Bradley G., DrPH</creatorcontrib><creatorcontrib>Allen LaPointe, Nancy M., PharmD, MHS</creatorcontrib><creatorcontrib>Curtis, Lesley H., PhD</creatorcontrib><creatorcontrib>Al-Khatib, Sana M., MD, MHS</creatorcontrib><title>Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Ventricular tachycardia (VT) is common in cardiomyopathy patients with an implantable cardioverter-defibrillator. This analysis evaluated antiarrhythmic medication use and change in use over time in patients with VT and structural heart disease. Query of Medicare claims identified patients with an implantable cardioverter-defibrillator and VT. Patients with atrial fibrillation or supraventricular tachycardia were excluded. Two cohorts were created of patients enrolled in Medicare Part D for the 12 months before 2007 and 2012. Patients were identified through a search for antiarrhythmic medication fills with a supply covering January 1 of the cohort year. Adjusted logistic regression modeling evaluated the association between patient characteristics and antiarrhythmic medication use. The 2007 (n = 2,334) and 2012 (n = 3,892) Medicare Part D cohorts had similar demographics: median age 76 years, 64%-67% male, and 87%-89% white. Of the 2007 cohort, 1,380 (59%) patients were on a beta blocker, and 484 (20.7%) were on an antiarrhythmic medication (70% amiodarone and 20% sotalol). Between 2007 and 2012, there was a statistically significant higher use of any antiarrhythmic medication (p = 0.014), beta blockers (p &lt;0.0001), mexiletine (p = 0.005), and ranolazine (p &lt;0.0001), while amiodarone use remained unchanged (p = 0.53). After multivariable adjustment, male gender and renal disease were associated with higher antiarrhythmic medication use. In conclusion, although antiarrhythmic medication and beta blocker use in patients with VT increased over time, &lt;1 in 4 patients were on an antiarrhythmic medication and only 65% of the patients were on a beta blocker.</description><subject>Ablation</subject><subject>Acute coronary syndromes</subject><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amiodarone</subject><subject>Amiodarone - therapeutic use</subject><subject>Anemia</subject><subject>Anomalies</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Antiarrhythmics</subject><subject>Arrhythmia</subject><subject>Atenolol</subject><subject>Cancer</subject><subject>Cardiac arrhythmia</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cerebral infarction</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Circulation</subject><subject>Classification</subject><subject>Clinical trials</subject><subject>Codes</subject><subject>Complications</subject><subject>Congenital defects</subject><subject>Congestive heart failure</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Damage</subject><subject>Databases, Factual</subject><subject>Death, Sudden, Cardiac - prevention &amp; control</subject><subject>Defibrillators, Implantable</subject><subject>Diabetes mellitus</subject><subject>Diagnosis</subject><subject>Drugs</subject><subject>Electric Countershock</subject><subject>Electrocardiography</subject><subject>Enrollments</subject><subject>Female</subject><subject>Generic drugs</subject><subject>Government programs</subject><subject>Guidelines</subject><subject>Health care</subject><subject>Health risks</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Intervention</subject><subject>Ischemia</subject><subject>Kidney transplantation</subject><subject>Logistic Models</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Medical instruments</subject><subject>Medicare</subject><subject>Medicare Part D</subject><subject>Mexiletine - therapeutic use</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Patients</subject><subject>Population studies</subject><subject>Populations</subject><subject>Prescription drugs</subject><subject>Prevention</subject><subject>Quality of life</subject><subject>Ranolazine - therapeutic use</subject><subject>Regression analysis</subject><subject>Renal failure</subject><subject>Risk</subject><subject>Skin</subject><subject>Sodium Channel Blockers - therapeutic use</subject><subject>Sotalol - therapeutic use</subject><subject>Statistical tests</subject><subject>Stroke</subject><subject>Survival</subject><subject>Tachycardia, Ventricular - therapy</subject><subject>Terminology</subject><subject>Transplants &amp; implants</subject><subject>United States</subject><subject>Ventricle</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkkuLFDEQgBtR3HH1JygBL166rUr6eVGWWR8LKwru6jGkk2ombT_GJL0w_8CfbZoZFfbiKRR8Vamqr5LkOUKGgOXrPlNjr5UzGQesMsAMBDxINlhXTYoNiofJBgB42mDenCVPvO9jiFiUj5MzXoscRQmb5NetJzZ37GIKVjm3O4TdaDX7RMZqFew8eWanU-iIfVEusMv4BEtT8Oy7DTumJnY17gc1BdUOxLaxKTvfkQvk0kvqbOvsMKgwu0ga9i0mOquXQTl2o_TusA5h1dPkUacGT89O73ly-_7dzfZjev35w9X24jrVeV6H1PAKOfC8besiN8bUHZZFq5BaoagC0RUNqJpXuSkK6lAY6EpBVVULFIRdIc6TV8e6ezf_XMgHOVqvKTY40bx4iXWNvGwA8oi-vIf28-Km2N1KRYwXZROp4khpN3vvqJN7Z0flDhJBrqpkL0-q5KpKAsqoKua9OFVf2pHM36w_biLw9ghQXMedJSe9jlvX0YUjHaSZ7X-_eHOvgh7sFE0OP-hA_t800nMJ8ut6L-u5YCUAeVOJ38QyvO8</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Pokorney, Sean D., MD, MBA</creator><creator>Mi, Xiaojuan, PhD</creator><creator>Hammill, Bradley G., DrPH</creator><creator>Allen LaPointe, Nancy M., PharmD, MHS</creator><creator>Curtis, Lesley H., PhD</creator><creator>Al-Khatib, Sana M., MD, MHS</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4345-0816</orcidid></search><sort><creationdate>20170501</creationdate><title>Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia</title><author>Pokorney, Sean D., MD, MBA ; Mi, Xiaojuan, PhD ; Hammill, Bradley G., DrPH ; Allen LaPointe, Nancy M., PharmD, MHS ; Curtis, Lesley H., PhD ; Al-Khatib, Sana M., MD, MHS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-d2712024bb854ddd8f165ba1eb3ae703f590a8274d55ef13d0f63e778313e1f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Ablation</topic><topic>Acute coronary syndromes</topic><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amiodarone</topic><topic>Amiodarone - therapeutic use</topic><topic>Anemia</topic><topic>Anomalies</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Antiarrhythmics</topic><topic>Arrhythmia</topic><topic>Atenolol</topic><topic>Cancer</topic><topic>Cardiac arrhythmia</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cerebral infarction</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Circulation</topic><topic>Classification</topic><topic>Clinical trials</topic><topic>Codes</topic><topic>Complications</topic><topic>Congenital defects</topic><topic>Congestive heart failure</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary vessels</topic><topic>Damage</topic><topic>Databases, Factual</topic><topic>Death, Sudden, Cardiac - prevention &amp; control</topic><topic>Defibrillators, Implantable</topic><topic>Diabetes mellitus</topic><topic>Diagnosis</topic><topic>Drugs</topic><topic>Electric Countershock</topic><topic>Electrocardiography</topic><topic>Enrollments</topic><topic>Female</topic><topic>Generic drugs</topic><topic>Government programs</topic><topic>Guidelines</topic><topic>Health care</topic><topic>Health risks</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Intervention</topic><topic>Ischemia</topic><topic>Kidney transplantation</topic><topic>Logistic Models</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Medical instruments</topic><topic>Medicare</topic><topic>Medicare Part D</topic><topic>Mexiletine - therapeutic use</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Patients</topic><topic>Population studies</topic><topic>Populations</topic><topic>Prescription drugs</topic><topic>Prevention</topic><topic>Quality of life</topic><topic>Ranolazine - therapeutic use</topic><topic>Regression analysis</topic><topic>Renal failure</topic><topic>Risk</topic><topic>Skin</topic><topic>Sodium Channel Blockers - therapeutic use</topic><topic>Sotalol - therapeutic use</topic><topic>Statistical tests</topic><topic>Stroke</topic><topic>Survival</topic><topic>Tachycardia, Ventricular - therapy</topic><topic>Terminology</topic><topic>Transplants &amp; implants</topic><topic>United States</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pokorney, Sean D., MD, MBA</creatorcontrib><creatorcontrib>Mi, Xiaojuan, PhD</creatorcontrib><creatorcontrib>Hammill, Bradley G., DrPH</creatorcontrib><creatorcontrib>Allen LaPointe, Nancy M., PharmD, MHS</creatorcontrib><creatorcontrib>Curtis, Lesley H., PhD</creatorcontrib><creatorcontrib>Al-Khatib, Sana M., MD, MHS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing &amp; Allied Health Source</collection><collection>Physical Education Index</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pokorney, Sean D., MD, MBA</au><au>Mi, Xiaojuan, PhD</au><au>Hammill, Bradley G., DrPH</au><au>Allen LaPointe, Nancy M., PharmD, MHS</au><au>Curtis, Lesley H., PhD</au><au>Al-Khatib, Sana M., MD, MHS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>119</volume><issue>9</issue><spage>1401</spage><epage>1406</epage><pages>1401-1406</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>Ventricular tachycardia (VT) is common in cardiomyopathy patients with an implantable cardioverter-defibrillator. This analysis evaluated antiarrhythmic medication use and change in use over time in patients with VT and structural heart disease. Query of Medicare claims identified patients with an implantable cardioverter-defibrillator and VT. Patients with atrial fibrillation or supraventricular tachycardia were excluded. Two cohorts were created of patients enrolled in Medicare Part D for the 12 months before 2007 and 2012. Patients were identified through a search for antiarrhythmic medication fills with a supply covering January 1 of the cohort year. Adjusted logistic regression modeling evaluated the association between patient characteristics and antiarrhythmic medication use. The 2007 (n = 2,334) and 2012 (n = 3,892) Medicare Part D cohorts had similar demographics: median age 76 years, 64%-67% male, and 87%-89% white. Of the 2007 cohort, 1,380 (59%) patients were on a beta blocker, and 484 (20.7%) were on an antiarrhythmic medication (70% amiodarone and 20% sotalol). Between 2007 and 2012, there was a statistically significant higher use of any antiarrhythmic medication (p = 0.014), beta blockers (p &lt;0.0001), mexiletine (p = 0.005), and ranolazine (p &lt;0.0001), while amiodarone use remained unchanged (p = 0.53). After multivariable adjustment, male gender and renal disease were associated with higher antiarrhythmic medication use. In conclusion, although antiarrhythmic medication and beta blocker use in patients with VT increased over time, &lt;1 in 4 patients were on an antiarrhythmic medication and only 65% of the patients were on a beta blocker.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28341360</pmid><doi>10.1016/j.amjcard.2017.01.030</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4345-0816</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0002-9149
ispartof The American journal of cardiology, 2017-05, Vol.119 (9), p.1401-1406
issn 0002-9149
1879-1913
language eng
recordid cdi_proquest_miscellaneous_1881269004
source MEDLINE; Elsevier ScienceDirect Journals
subjects Ablation
Acute coronary syndromes
Adrenergic beta-Antagonists - therapeutic use
Aged
Aged, 80 and over
Amiodarone
Amiodarone - therapeutic use
Anemia
Anomalies
Anti-Arrhythmia Agents - therapeutic use
Antiarrhythmics
Arrhythmia
Atenolol
Cancer
Cardiac arrhythmia
Cardiomyopathy
Cardiovascular
Cardiovascular disease
Cardiovascular diseases
Cerebral infarction
Chronic obstructive pulmonary disease
Circulation
Classification
Clinical trials
Codes
Complications
Congenital defects
Congestive heart failure
Coronary artery
Coronary artery disease
Coronary vessels
Damage
Databases, Factual
Death, Sudden, Cardiac - prevention & control
Defibrillators, Implantable
Diabetes mellitus
Diagnosis
Drugs
Electric Countershock
Electrocardiography
Enrollments
Female
Generic drugs
Government programs
Guidelines
Health care
Health risks
Heart
Heart attacks
Heart failure
Hospitals
Humans
Hypertension
Incidence
Intervention
Ischemia
Kidney transplantation
Logistic Models
Lung diseases
Male
Mathematical models
Medical instruments
Medicare
Medicare Part D
Mexiletine - therapeutic use
Mortality
Myocardial infarction
Patients
Population studies
Populations
Prescription drugs
Prevention
Quality of life
Ranolazine - therapeutic use
Regression analysis
Renal failure
Risk
Skin
Sodium Channel Blockers - therapeutic use
Sotalol - therapeutic use
Statistical tests
Stroke
Survival
Tachycardia, Ventricular - therapy
Terminology
Transplants & implants
United States
Ventricle
title Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T01%3A31%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%20Antiarrhythmic%20Medications%20in%20Medicare%20Part%20D%20Patients%20With%20an%20Implantable%20Cardioverter-Defibrillator%20and%20Ventricular%20Tachycardia&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Pokorney,%20Sean%20D.,%20MD,%20MBA&rft.date=2017-05-01&rft.volume=119&rft.issue=9&rft.spage=1401&rft.epage=1406&rft.pages=1401-1406&rft.issn=0002-9149&rft.eissn=1879-1913&rft_id=info:doi/10.1016/j.amjcard.2017.01.030&rft_dat=%3Cproquest_cross%3E1888122569%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1888122569&rft_id=info:pmid/28341360&rft_els_id=S0002914917301297&rfr_iscdi=true