Autism-like behavior in the BTBR mouse model of autism is improved by propofol
Autism spectrum disorder (ASD) is a developmental disorder that is characterized by symptoms of impaired social interactions, restricted interests and repetitive behaviors. Recent studies in humans and animal-models suggest that reduced GABAergic neurotransmission in the brain may underlie autism-re...
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| Veröffentlicht in: | Neuropharmacology 2017-05, Vol.118, p.175-187 |
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| creator | Cai, Yulong Wang, Lian Xiao, Rui Li, Xin He, Xie Gao, Junwei Xu, Haiwei Fan, Xiaotang |
| description | Autism spectrum disorder (ASD) is a developmental disorder that is characterized by symptoms of impaired social interactions, restricted interests and repetitive behaviors. Recent studies in humans and animal-models suggest that reduced GABAergic neurotransmission in the brain may underlie autism-related behavioral symptoms. It has been shown that propofol, a commonly used anesthetic, facilitates γ-aminobutyric acid-mediated inhibitory synaptic transmission. The present study investigated whether propofol improved autistic phenotypes in BTBR T + Itpr3tf/J (BTBR) mice, a model of idiopathic autism. We found that i.p. injection of propofol in BTBR mice significantly improved aspects of social approach and repetitive behaviors without affecting reciprocal social interactions and without any detrimental effects in C57BL/6J mice. The ability of propofol to improve autistic phenotypes in BTBR mice through GABAergic neurotransmission suggests a potential pharmacological target for interventions to treat symptoms of autism.
•Propofol was the first time to be used in the model of ASD.•Propofol could improve social approach and repetitive behaviors in BTBR mice.•This findings support the hypothesis that enhancing inhibitory synaptic transmission offers a therapeutic strategy for ASD. |
| doi_str_mv | 10.1016/j.neuropharm.2017.03.021 |
| format | Article |
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•Propofol was the first time to be used in the model of ASD.•Propofol could improve social approach and repetitive behaviors in BTBR mice.•This findings support the hypothesis that enhancing inhibitory synaptic transmission offers a therapeutic strategy for ASD.</description><identifier>ISSN: 0028-3908</identifier><identifier>EISSN: 1873-7064</identifier><identifier>DOI: 10.1016/j.neuropharm.2017.03.021</identifier><identifier>PMID: 28341205</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adaptation, Ocular - drug effects ; Analysis of Variance ; Anesthetics, Intravenous - therapeutic use ; Animals ; Autism spectrum disorder ; Autistic Disorder - drug therapy ; Autistic Disorder - genetics ; Autistic Disorder - physiopathology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Exploratory Behavior - drug effects ; Female ; Grooming - drug effects ; Interpersonal Relations ; Male ; Maze Learning - drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Nerve Tissue Proteins - genetics ; Propofol ; Propofol - therapeutic use ; Repetitive behaviors ; Social approach</subject><ispartof>Neuropharmacology, 2017-05, Vol.118, p.175-187</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-6344876337861ed32364d80f0555e00890ad4979377d9a10ac629d9c78535703</citedby><cites>FETCH-LOGICAL-c440t-6344876337861ed32364d80f0555e00890ad4979377d9a10ac629d9c78535703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0028390817301144$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28341205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Yulong</creatorcontrib><creatorcontrib>Wang, Lian</creatorcontrib><creatorcontrib>Xiao, Rui</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>He, Xie</creatorcontrib><creatorcontrib>Gao, Junwei</creatorcontrib><creatorcontrib>Xu, Haiwei</creatorcontrib><creatorcontrib>Fan, Xiaotang</creatorcontrib><title>Autism-like behavior in the BTBR mouse model of autism is improved by propofol</title><title>Neuropharmacology</title><addtitle>Neuropharmacology</addtitle><description>Autism spectrum disorder (ASD) is a developmental disorder that is characterized by symptoms of impaired social interactions, restricted interests and repetitive behaviors. Recent studies in humans and animal-models suggest that reduced GABAergic neurotransmission in the brain may underlie autism-related behavioral symptoms. It has been shown that propofol, a commonly used anesthetic, facilitates γ-aminobutyric acid-mediated inhibitory synaptic transmission. The present study investigated whether propofol improved autistic phenotypes in BTBR T + Itpr3tf/J (BTBR) mice, a model of idiopathic autism. We found that i.p. injection of propofol in BTBR mice significantly improved aspects of social approach and repetitive behaviors without affecting reciprocal social interactions and without any detrimental effects in C57BL/6J mice. The ability of propofol to improve autistic phenotypes in BTBR mice through GABAergic neurotransmission suggests a potential pharmacological target for interventions to treat symptoms of autism.
•Propofol was the first time to be used in the model of ASD.•Propofol could improve social approach and repetitive behaviors in BTBR mice.•This findings support the hypothesis that enhancing inhibitory synaptic transmission offers a therapeutic strategy for ASD.</description><subject>Adaptation, Ocular - drug effects</subject><subject>Analysis of Variance</subject><subject>Anesthetics, Intravenous - therapeutic use</subject><subject>Animals</subject><subject>Autism spectrum disorder</subject><subject>Autistic Disorder - drug therapy</subject><subject>Autistic Disorder - genetics</subject><subject>Autistic Disorder - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Exploratory Behavior - drug effects</subject><subject>Female</subject><subject>Grooming - drug effects</subject><subject>Interpersonal Relations</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred Strains</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Propofol</subject><subject>Propofol - therapeutic use</subject><subject>Repetitive behaviors</subject><subject>Social approach</subject><issn>0028-3908</issn><issn>1873-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P7CAUhonR6PjxFwxLN62HQgssHeNVE6OJmT1hymmGsR3mQjuJ_168o9elm8NZPC8vPIRQBiUD1lyvyw1OMWxXNg5lBUyWwEuo2AGZMSV5IaERh2QGUKmCa1An5DSlNQAIxdQxOakUF6yCekaeb6bRp6Ho_RvSJa7szodI_YaOK6TzxfyVDmFKmKfDnoaO2n889Yn6YRvDDh1dvtO8bUMX-nNy1Nk-4cXXeUYWf-4Wtw_F08v94-3NU9EKAWPRcCGUbDiXqmHoeMUb4RR0UNc1AigN1gktNZfSacvAtk2lnW6lqnktgZ-Rq_21uffvhGk0g08t9r3dYH6uYUqxqlFC64yqPdrGkFLEzmyjH2x8NwzMp0yzNj8yzadMA9xkmTl6-dUyLQd0_4Pf9jIw3wOYv7rzGE1qPW5adD5iOxoX_O8tH2a2iNo</recordid><startdate>20170515</startdate><enddate>20170515</enddate><creator>Cai, Yulong</creator><creator>Wang, Lian</creator><creator>Xiao, Rui</creator><creator>Li, Xin</creator><creator>He, Xie</creator><creator>Gao, Junwei</creator><creator>Xu, Haiwei</creator><creator>Fan, Xiaotang</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170515</creationdate><title>Autism-like behavior in the BTBR mouse model of autism is improved by propofol</title><author>Cai, Yulong ; Wang, Lian ; Xiao, Rui ; Li, Xin ; He, Xie ; Gao, Junwei ; Xu, Haiwei ; Fan, Xiaotang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-6344876337861ed32364d80f0555e00890ad4979377d9a10ac629d9c78535703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptation, Ocular - drug effects</topic><topic>Analysis of Variance</topic><topic>Anesthetics, Intravenous - therapeutic use</topic><topic>Animals</topic><topic>Autism spectrum disorder</topic><topic>Autistic Disorder - drug therapy</topic><topic>Autistic Disorder - genetics</topic><topic>Autistic Disorder - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Exploratory Behavior - drug effects</topic><topic>Female</topic><topic>Grooming - drug effects</topic><topic>Interpersonal Relations</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred Strains</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Propofol</topic><topic>Propofol - therapeutic use</topic><topic>Repetitive behaviors</topic><topic>Social approach</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Yulong</creatorcontrib><creatorcontrib>Wang, Lian</creatorcontrib><creatorcontrib>Xiao, Rui</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>He, Xie</creatorcontrib><creatorcontrib>Gao, Junwei</creatorcontrib><creatorcontrib>Xu, Haiwei</creatorcontrib><creatorcontrib>Fan, Xiaotang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Yulong</au><au>Wang, Lian</au><au>Xiao, Rui</au><au>Li, Xin</au><au>He, Xie</au><au>Gao, Junwei</au><au>Xu, Haiwei</au><au>Fan, Xiaotang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autism-like behavior in the BTBR mouse model of autism is improved by propofol</atitle><jtitle>Neuropharmacology</jtitle><addtitle>Neuropharmacology</addtitle><date>2017-05-15</date><risdate>2017</risdate><volume>118</volume><spage>175</spage><epage>187</epage><pages>175-187</pages><issn>0028-3908</issn><eissn>1873-7064</eissn><abstract>Autism spectrum disorder (ASD) is a developmental disorder that is characterized by symptoms of impaired social interactions, restricted interests and repetitive behaviors. Recent studies in humans and animal-models suggest that reduced GABAergic neurotransmission in the brain may underlie autism-related behavioral symptoms. It has been shown that propofol, a commonly used anesthetic, facilitates γ-aminobutyric acid-mediated inhibitory synaptic transmission. The present study investigated whether propofol improved autistic phenotypes in BTBR T + Itpr3tf/J (BTBR) mice, a model of idiopathic autism. We found that i.p. injection of propofol in BTBR mice significantly improved aspects of social approach and repetitive behaviors without affecting reciprocal social interactions and without any detrimental effects in C57BL/6J mice. The ability of propofol to improve autistic phenotypes in BTBR mice through GABAergic neurotransmission suggests a potential pharmacological target for interventions to treat symptoms of autism.
•Propofol was the first time to be used in the model of ASD.•Propofol could improve social approach and repetitive behaviors in BTBR mice.•This findings support the hypothesis that enhancing inhibitory synaptic transmission offers a therapeutic strategy for ASD.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28341205</pmid><doi>10.1016/j.neuropharm.2017.03.021</doi><tpages>13</tpages></addata></record> |
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| subjects | Adaptation, Ocular - drug effects Analysis of Variance Anesthetics, Intravenous - therapeutic use Animals Autism spectrum disorder Autistic Disorder - drug therapy Autistic Disorder - genetics Autistic Disorder - physiopathology Disease Models, Animal Dose-Response Relationship, Drug Exploratory Behavior - drug effects Female Grooming - drug effects Interpersonal Relations Male Maze Learning - drug effects Mice Mice, Inbred C57BL Mice, Inbred Strains Nerve Tissue Proteins - genetics Propofol Propofol - therapeutic use Repetitive behaviors Social approach |
| title | Autism-like behavior in the BTBR mouse model of autism is improved by propofol |
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