Lipidomic profiling of endometrial fluid in women with ovarian endometriosis
The proteomic content of the endometrial fluid (EF) from patients with endometriosis has been investigated, but the lipidomic profile has not been analyzed yet in detail. This study is a comparative untargeted lipidomic analysis of human EF obtained from 35 patients (12 endometriosis and 23 controls...
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| Veröffentlicht in: | Biology of reproduction 2017-04, Vol.96 (4), p.772-779 |
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| creator | Domínguez, Francisco Ferrando, Marcos Díaz-Gimeno, Patricia Quintana, Fernando Fernández, Gemma Castells, Inés Simón, Carlos |
| description | The proteomic content of the endometrial fluid (EF) from patients with endometriosis has been investigated, but the lipidomic profile has not been analyzed yet in detail. This study is a comparative untargeted lipidomic analysis of human EF obtained from 35 patients (12 endometriosis and 23 controls). Global differential lipidomic profile was analyzed in both groups by ultrahigh performance liquid chromatography coupled to mass spectrometry. A total of 123 out of the 457 metabolites identified in the EF were found to be significantly differentially expressed between ovarian endometriosis (OE) versus controls. Univariate statistical analysis showed reduced levels of saturated diacylglycerols and saturated triacylglycerols in endometriosis patients. A predictive model was generated using the 123 differentially expressed metabolites. Using this model, we were able to correctly classify 86% of the samples. This study identified the lipidomic profile in the EF associated with OE, suggesting that EF analysis could be considered as a minimally invasive approach for the diagnosis of endometriosis. In conclusion, the lipidomic profile of the EF is different between samples from patients with OE and controls. Summary Sentence The lipidomic profile of endometrial fluid in women with endometriosis is different from controls offering a novel opportunity for the minimally invasive diagnosis of endometriosis. |
| doi_str_mv | 10.1093/biolre/iox014 |
| format | Article |
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This study is a comparative untargeted lipidomic analysis of human EF obtained from 35 patients (12 endometriosis and 23 controls). Global differential lipidomic profile was analyzed in both groups by ultrahigh performance liquid chromatography coupled to mass spectrometry. A total of 123 out of the 457 metabolites identified in the EF were found to be significantly differentially expressed between ovarian endometriosis (OE) versus controls. Univariate statistical analysis showed reduced levels of saturated diacylglycerols and saturated triacylglycerols in endometriosis patients. A predictive model was generated using the 123 differentially expressed metabolites. Using this model, we were able to correctly classify 86% of the samples. This study identified the lipidomic profile in the EF associated with OE, suggesting that EF analysis could be considered as a minimally invasive approach for the diagnosis of endometriosis. In conclusion, the lipidomic profile of the EF is different between samples from patients with OE and controls. Summary Sentence The lipidomic profile of endometrial fluid in women with endometriosis is different from controls offering a novel opportunity for the minimally invasive diagnosis of endometriosis.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1093/biolre/iox014</identifier><identifier>PMID: 28340140</identifier><language>eng</language><publisher>United States: Society for the Study of Reproduction</publisher><subject>Adolescent ; Adult ; Body Fluids - chemistry ; Case-Control Studies ; endometrial fluid ; Endometriosis ; Endometriosis - metabolism ; Endometrium - metabolism ; Female ; Humans ; Lipid Metabolism - physiology ; lipidomic profile ; Lipids - chemistry ; Metabolites ; Womens health ; Young Adult</subject><ispartof>Biology of reproduction, 2017-04, Vol.96 (4), p.772-779</ispartof><rights>The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please journals.permissions@oup.com journals.permissions@oup.com</rights><rights>The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please journals.permissions@oup.com 2017</rights><rights>The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please journals.permissions@oup.com.</rights><rights>Copyright © 2017 Society for the Study of Reproduction</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b429t-7ff6325482dfdaf4fb398297c4e2807efce7cb64c6f6a00d3cd541fa34ecda5a3</citedby><cites>FETCH-LOGICAL-b429t-7ff6325482dfdaf4fb398297c4e2807efce7cb64c6f6a00d3cd541fa34ecda5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28340140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domínguez, Francisco</creatorcontrib><creatorcontrib>Ferrando, Marcos</creatorcontrib><creatorcontrib>Díaz-Gimeno, Patricia</creatorcontrib><creatorcontrib>Quintana, Fernando</creatorcontrib><creatorcontrib>Fernández, Gemma</creatorcontrib><creatorcontrib>Castells, Inés</creatorcontrib><creatorcontrib>Simón, Carlos</creatorcontrib><title>Lipidomic profiling of endometrial fluid in women with ovarian endometriosis</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>The proteomic content of the endometrial fluid (EF) from patients with endometriosis has been investigated, but the lipidomic profile has not been analyzed yet in detail. This study is a comparative untargeted lipidomic analysis of human EF obtained from 35 patients (12 endometriosis and 23 controls). Global differential lipidomic profile was analyzed in both groups by ultrahigh performance liquid chromatography coupled to mass spectrometry. A total of 123 out of the 457 metabolites identified in the EF were found to be significantly differentially expressed between ovarian endometriosis (OE) versus controls. Univariate statistical analysis showed reduced levels of saturated diacylglycerols and saturated triacylglycerols in endometriosis patients. A predictive model was generated using the 123 differentially expressed metabolites. Using this model, we were able to correctly classify 86% of the samples. This study identified the lipidomic profile in the EF associated with OE, suggesting that EF analysis could be considered as a minimally invasive approach for the diagnosis of endometriosis. In conclusion, the lipidomic profile of the EF is different between samples from patients with OE and controls. Summary Sentence The lipidomic profile of endometrial fluid in women with endometriosis is different from controls offering a novel opportunity for the minimally invasive diagnosis of endometriosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Body Fluids - chemistry</subject><subject>Case-Control Studies</subject><subject>endometrial fluid</subject><subject>Endometriosis</subject><subject>Endometriosis - metabolism</subject><subject>Endometrium - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Lipid Metabolism - physiology</subject><subject>lipidomic profile</subject><subject>Lipids - chemistry</subject><subject>Metabolites</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkElLxDAAhYMozjh69CoFL4LUydY0OcrgBgUvei5pFs3QNrVpXf69kY4OeJlLQl4-Ho8PgFMErxAUZFk5X_dm6fwnRHQPzFGGRZpjxvfBHELIUkIYmYGjENYwEgSTQzDDnND4gHNQFK5z2jdOJV3vratd-5J4m5g2hmbonawTW49OJ65NPmIUTze8Jv5dxr92y_ngwjE4sLIO5mRzL8Dz7c3T6j4tHu8eVtdFWlEshjS3lhGcUY611dJSWxHBscgVNZjD3FhlclUxqphlEkJNlM4ospJQo7TMJFmAi6k3Tn4bTRjKxgVl6lq2xo-hRJyjaAAxGNHzf-jaj30b15VIMCEIgYhHKp0o1fsQemPLrneN7L9KBMsfzeWkuZw0R_5s0zpWjdF_9K_X7UI_dju7Lic0xr41O-hvuE6YYQ</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Domínguez, Francisco</creator><creator>Ferrando, Marcos</creator><creator>Díaz-Gimeno, Patricia</creator><creator>Quintana, Fernando</creator><creator>Fernández, Gemma</creator><creator>Castells, Inés</creator><creator>Simón, Carlos</creator><general>Society for the Study of Reproduction</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Lipidomic profiling of endometrial fluid in women with ovarian endometriosis</title><author>Domínguez, Francisco ; 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This study is a comparative untargeted lipidomic analysis of human EF obtained from 35 patients (12 endometriosis and 23 controls). Global differential lipidomic profile was analyzed in both groups by ultrahigh performance liquid chromatography coupled to mass spectrometry. A total of 123 out of the 457 metabolites identified in the EF were found to be significantly differentially expressed between ovarian endometriosis (OE) versus controls. Univariate statistical analysis showed reduced levels of saturated diacylglycerols and saturated triacylglycerols in endometriosis patients. A predictive model was generated using the 123 differentially expressed metabolites. Using this model, we were able to correctly classify 86% of the samples. This study identified the lipidomic profile in the EF associated with OE, suggesting that EF analysis could be considered as a minimally invasive approach for the diagnosis of endometriosis. In conclusion, the lipidomic profile of the EF is different between samples from patients with OE and controls. Summary Sentence The lipidomic profile of endometrial fluid in women with endometriosis is different from controls offering a novel opportunity for the minimally invasive diagnosis of endometriosis.</abstract><cop>United States</cop><pub>Society for the Study of Reproduction</pub><pmid>28340140</pmid><doi>10.1093/biolre/iox014</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Body Fluids - chemistry Case-Control Studies endometrial fluid Endometriosis Endometriosis - metabolism Endometrium - metabolism Female Humans Lipid Metabolism - physiology lipidomic profile Lipids - chemistry Metabolites Womens health Young Adult |
| title | Lipidomic profiling of endometrial fluid in women with ovarian endometriosis |
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