Metabolic profiling of tyrosine, tryptophan, and glutamate in human urine using gas chromatography–tandem mass spectrometry combined with single SPE cleanup

•A GC–MS/MS method for the metabolic profiling of tyrosine, tryptophan, and glutamate in urine.•Significant decrement of hydrolysis yields for indole amines under high HCl concentration.•Single MCX-SPE cartridge for rapid cleanup of acidic and basic neurochemicals in urine.•Selection of appropriate...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2017-04, Vol.1051, p.97-107
Hauptverfasser:	Shin, Hyun Ju, Park, Na Hyun, Lee, Wonwoong, Choi, Man Ho, Chung, Bong Chul, Hong, Jongki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidic hydrolysis Biomarkers - metabolism Biomarkers - urine Chemical derivatization Gas Chromatography-Mass Spectrometry - methods GC–MS/MS Glutamic Acid - metabolism Glutamic Acid - urine Humans Limit of Detection MCX-SPE Metabolome Metabolomics - methods Neuronal diseases Neurotransmitters Solid Phase Extraction - methods Tandem Mass Spectrometry - methods Tryptophan - metabolism Tryptophan - urine Tyrosine - metabolism Tyrosine - urine
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